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AMG-8718 , CAS No.A607608, Inhibitor of beta-secretase 1

COA COA
In stock
Item Number
A607608
Grouped product items
SKU Size
Availability
 Price Qty
A607608-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,297.90
A607608-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,321.90
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beta-secretase 1 Inhibitor (33)

Basic Description

Specifications & Purity Moligand™
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of beta-secretase 1

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Benzopyrans
Subclass 1-benzopyrans
Intermediate Tree Nodes Chromenopyridines
Direct Parent Chromeno[2,3-b]pyridines
Alternative Parents Diarylethers  Pyranopyridines  2-halopyridines  Aryl fluorides  Benzenoids  Oxazolines  Heteroaromatic compounds  Oxetanes  Isoureas  Oxacyclic compounds  Dialkyl ethers  Carboximidamides  Propargyl-type 1,3-dipolar organic compounds  Azacyclic compounds  Hydrocarbon derivatives  Amines  Organofluorides  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Chromeno[2,3-b]pyridine - Diaryl ether - Pyranopyridine - 2-halopyridine - Aryl fluoride - Aryl halide - Pyridine - Benzenoid - Heteroaromatic compound - Oxazoline - Isourea - Oxetane - Organic 1,3-dipolar compound - Azacycle - Oxacycle - Ether - Dialkyl ether - Carboximidamide - Propargyl-type 1,3-dipolar organic compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Amine - Hydrocarbon derivative - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as chromeno[2,3-b]pyridines. These are aromatic heteropolycyclic compounds containing pyridine linearly fused to the pyran moiety of a benzofuran ring system.
External Descriptors Not available

Associated Targets(Human)

BACE1 Tchem Beta-secretase 1 (3 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
BACE2 Tchem Beta-secretase 2 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNH2 Tclin HERG (29587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CTSD Tchem Cathepsin D (3201 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BACE2 Tchem Beta secretase 2 (1716 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
REN Tclin Renin (5251 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CTSE Tchem Cathepsin E (189 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BACE1 Tchem Beta-secretase 1 (15641 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Canis familiaris (36305 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LLC-PK1 (2135 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cynomolgus monkey (4946 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasma (328 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

INCHI InChI=1S/C25H19FN4O3/c1-24(12-31-13-24)7-6-15-9-19-22(29-11-15)33-20-5-4-16(17-3-2-8-28-21(17)26)10-18(20)25(19)14-32-23(27)30-25/h2-5,8-11H,12-14H2,1H3,(H2,27,30)/t25-/m0/s1
InChIKey GKKFBOARESVMBW-VWLOTQADSA-N
Smiles NC1=N[C@]2(CO1)c1cc(C#CC3(C)COC3)cnc1Oc1c2cc(cc1)c1cccnc1F
Isomeric SMILES CC1(COC1)C#CC2=CC3=C(N=C2)OC4=C([C@@]35COC(=N5)N)C=C(C=C4)C6=C(N=CC=C6)F
PubChem CID 45254510

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Molecular Weight 442.400 g/mol
XLogP3 2.900
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 3
Exact Mass 442.144 Da
Monoisotopic Mass 442.144 Da
Topological Polar Surface Area 91.900 Ų
Heavy Atom Count 33
Formal Charge 0
Complexity 866.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 1
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

  1. LX-2343
    LX-2343
    • ≥98%

    Starting at $24.90

  2. LY2886721, Inhibitor of beta-secretase 1
    LY2886721, Inhibitor of beta-secretase 1

    Starting at $22.90

  3. AZD3293 (Lanabecestat), Inhibitor of beta-secretase 1
    AZD3293 (Lanabecestat), Inhibitor of beta-secretase 1

    Starting at $89.90

  4. AZD3839, Inhibitor of beta-secretase 1
    AZD3839, Inhibitor of beta-secretase 1

    Starting at $33.90

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