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Ambroxol HCl - ≥99%, high purity , CAS No.23828-92-4

3 Citations COA COA
    Grade & Purity:
  • ≥99%
In stock
Item Number
A129556
Grouped product items
SKU Size
Availability
 Price Qty
A129556-1g
1g
2
$19.90
A129556-5g
5g
5
$76.90
A129556-25g
25g
2
$301.90
A129556-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,084.90
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Bulk Order  SDS  DATASHEET  Specification Sheet

Antioxidant, anti-inflammatory agent. Na + channel blocker and mucolytic agent.

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Basic Description

Synonyms Hustless (TN) | NCGC00092387-01 | trans-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride | Ambroxol hydrochloride | Ambroxol hydrochloride 100 microg/mL in Acetonitrile | Ambroxolhydrochloride | Ponophen | Q27275396 | 4-{[(2-Amino-3,5-dibrom
Specifications & Purity ≥99%
Biochemical and Physiological Mechanisms Ambroxol hydrochloride is a small molecule expectorant and mucolytic agent with antioxidant and antiinflammatory effects. Ambroxol stimulates the secretion of surfactant which decreases mucus adhesion to the bronchial lining and produces expectorant effec
Shipped In Normal
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.
An expectorant antioxidant and antiinflammatory agent

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Phenylmethylamines
Intermediate Tree Nodes Not available
Direct Parent Phenylmethylamines
Alternative Parents Benzylamines  2-bromoanilines  Cyclohexylamines  Cyclohexanols  Bromobenzenes  Aralkylamines  Aryl bromides  Cyclic alcohols and derivatives  Dialkylamines  Primary amines  Organopnictogen compounds  Organobromides  Hydrochlorides  Hydrocarbon derivatives  
Molecular Framework Aromatic homomonocyclic compounds
Substituents Benzylamine - Aniline or substituted anilines - 2-bromoaniline - Phenylmethylamine - Bromobenzene - Cyclohexanol - Aralkylamine - Cyclohexylamine - Halobenzene - Aryl bromide - Aryl halide - Cyclic alcohol - Secondary alcohol - Secondary aliphatic amine - Secondary amine - Organooxygen compound - Organonitrogen compound - Organobromide - Organohalogen compound - Hydrochloride - Alcohol - Hydrocarbon derivative - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Primary amine - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as phenylmethylamines. These are compounds containing a phenylmethtylamine moiety, which consists of a phenyl group substituted by an methanamine.
External Descriptors Not available

Associated Targets(Human)

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488187420
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488187420
IUPAC Name 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydrochloride
INCHI InChI=1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H
InChIKey QNVKOSLOVOTXKF-UHFFFAOYSA-N
Smiles C1CC(CCC1NCC2=C(C(=CC(=C2)Br)Br)N)O.Cl
Isomeric SMILES C1CC(CCC1NCC2=C(C(=CC(=C2)Br)Br)N)O.Cl
RTECS GV8425000
Alternate CAS 18683-91-5
Molecular Weight 414.56
Reaxy-Rn 6882396
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6882396&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot Number Certificate Type Date Item
F2513019 Certificate of Analysis Feb 07, 2025 A129556
B2505040 Certificate of Analysis Feb 07, 2025 A129556
C2304018 Certificate of Analysis Dec 06, 2024 A129556
L2123304 Certificate of Analysis Oct 19, 2023 A129556
L2123424 Certificate of Analysis Oct 19, 2023 A129556
L2123298 Certificate of Analysis Oct 19, 2023 A129556
A1516025 Certificate of Analysis Sep 09, 2022 A129556
L2123301 Certificate of Analysis Dec 29, 2021 A129556
D2410035 Certificate of Analysis Dec 29, 2021 A129556

Chemical and Physical Properties

Solubility Soluble in methanol, water (~5 mg/ml), ethanol (~5 mg/ml), and DMSO (50 mM). Insoluble in ether.
Melt Point(°C) 235°C(dec.)(lit.)
Molecular Weight 414.560 g/mol
XLogP3
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 3
Exact Mass 413.953 Da
Monoisotopic Mass 411.955 Da
Topological Polar Surface Area 58.300 Ų
Heavy Atom Count 19
Formal Charge 0
Complexity 259.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Yushi Ding, Suyun Yu, Zhonghong Wei, Rui Deng, Peng Chen, Yifan Sun, Qi Jia, Xiaoman Li, Yuanyuan Wu, Wenxing Chen, Kurt S. Zanker, Aiyun Wang, Yin Lu.  (2020)  Relieving Sore Throat Formula Exerts a Therapeutic Effect on Pharyngitis through Immunoregulation and NF-κB Pathway.  MEDIATORS OF INFLAMMATION,  2020  (2929163). 
2. Sovichea Lay, Hai-ning Yu, Bao-xiang Hu, Sheng-rong Shen.  (2016)  Molecularly imprinted polymers as the extracted sorbents of clenbuterol ahead of liquid chromatographic determination.  Journal of Zhejiang University-SCIENCE B,  17  (6): ( 465–475). 
3. Binbin Shao, Chenkai Hu, Hainan Zhao, Chengcheng Xiao, Erdeng Du, Anhong Cai, Jing Deng.  (2024)  Degradation of ambroxol by UV/chloramine process: Kinetics, degradation pathway, and control of the risk of highly toxic disinfection by-products.  ENVIRONMENTAL POLLUTION,  363  (125091). 

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