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Amantadine hydrochloride - 99%（T）, high purity , Matrix protein 2 inhibitor, CAS No.665-66-7, Matrix protein 2 inhibitor

17 Citations COA COA
    Grade & Purity:
  • ≥99%(T)
In stock
Item Number
A109736
Grouped product items
SKU Size
Availability
 Price Qty
A109736-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$64.90
A109736-10g
10g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$90.90
A109736-25g
25g
3
$204.90
A109736-100g
100g
3
$737.90
A109736-500g
500g
2
$3,316.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Dopaminergic agent. Antiviral.

View related series
Anti-infection (2803) Apoptosis (4276) Bcl-2 Family (144) CDK (252) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Influenza Virus (253) Intrinsic Pathway (690) Orthopoxvirus (59) Pharmaceutical ingredients (367) SARS-CoV (200) Six membered carbocyclic compound (243) Virus (1811)

Basic Description

Synonyms AKOS015951188 | AMANTADINE HYDROCHLORIDE [MART.] | s2451 | Tricyclo(3.3.1.13,7)decan-1-amine, hydrochloride | AMANTADINE HYDROCHLORIDE [USP MONOGRAPH] | Symmetrel (TN) | Amantadinehydrochloride | NC00489 | SCHEMBL40713 | Adamantanamine hydrochloride | MLS
Specifications & Purity ≥99%(T)
Biochemical and Physiological Mechanisms Antiviral agent. Dopaminergic agent. Binds to M2 proton-selective ion channel of influenza. Uncompetitive NMDA receptor antagonist. Inhibits dopamine reuptake and induces D 2 and D 3 upregulation. Shows antiviral, antiparkinsonian and neuroprotective effe
Storage Temp Desiccated
Shipped In Normal
Action Type ANTAGONIST
Mechanism of action Matrix protein 2 inhibitor
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic nitrogen compounds
Class Organonitrogen compounds
Subclass Amines
Intermediate Tree Nodes Primary amines
Direct Parent Monoalkylamines
Alternative Parents Organopnictogen compounds  Hydrochlorides  Hydrocarbon derivatives  
Molecular Framework Aliphatic homopolycyclic compounds
Substituents Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Primary aliphatic amine - Aliphatic homopolycyclic compound
Description This compound belongs to the class of organic compounds known as monoalkylamines. These are organic compounds containing an primary aliphatic amine group.
External Descriptors hydrochloride

Associated Targets(Human)

THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLB Tchem DNA polymerase beta (23632 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ERG Tbio Transcriptional regulator ERG (5589 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SMN1 Tchem Survival motor neuron protein (34246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RAN Tchem GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 (21853 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KPNB1 Tbio Importin subunit beta-1/Snurportin-1 (25097 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus epidermidis (22802 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma brucei (78846 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Influenza B virus (2113 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Newcastle disease virus (78 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Influenza A virus (11224 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDCK (10148 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
srtA Sortase A (641 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
H2N2 subtype (35 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NS1 Nonstructural protein 1 (33327 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Grin1 Glutamate NMDA receptor (6467 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
M Matrix protein 2 (436 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504753907
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504753907
IUPAC Name adamantan-1-amine;hydrochloride
INCHI InChI=1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H
InChIKey WOLHOYHSEKDWQH-UHFFFAOYSA-N
Smiles C1C2CC3CC1CC(C2)(C3)N.Cl
Isomeric SMILES C1C2CC3CC1CC(C2)(C3)N.Cl
WGK Germany 3
RTECS AU4375000
Molecular Weight 187.71
Beilstein 4198854
Reaxy-Rn 4198854
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4198854&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

14 results found

Lot Number Certificate Type Date Item
I2109074 Certificate of Analysis Jun 09, 2025 A109736
I2109075 Certificate of Analysis Jun 09, 2025 A109736
I2109076 Certificate of Analysis Jun 09, 2025 A109736
I2109077 Certificate of Analysis Jun 09, 2025 A109736
E2528193 Certificate of Analysis Jul 23, 2024 A109736
D2418166 Certificate of Analysis Mar 25, 2024 A109736
D2418167 Certificate of Analysis Mar 25, 2024 A109736
D2418168 Certificate of Analysis Mar 25, 2024 A109736
I1905117 Certificate of Analysis Jun 09, 2023 A109736
I2209104 Certificate of Analysis Jul 04, 2022 A109736
I2209100 Certificate of Analysis Jul 04, 2022 A109736
I2209110 Certificate of Analysis Jul 04, 2022 A109736
I2318162 Certificate of Analysis Jul 04, 2022 A109736
I2209103 Certificate of Analysis Jul 04, 2022 A109736

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Chemical and Physical Properties

Solubility Soluble in water (50 mg/ml), ethanol (38 mg/ml at 25°C), chloroform (1:18), DMSO (38 mg/ml at 25°C), and methanol
Sensitivity Hygroscopic.
Melt Point(°C) >360°C
Molecular Weight 187.710 g/mol
XLogP3
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 1
Rotatable Bond Count 0
Exact Mass 187.113 Da
Monoisotopic Mass 187.113 Da
Topological Polar Surface Area 26.000 Ų
Heavy Atom Count 12
Formal Charge 0
Complexity 144.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Qiuhui Hu, Bo Zhang, Huiming Ren, Xiaoxuan Zhou, Chengbin He, Youqing Shen, Zhuxian Zhou, Hongjie Hu.  (2023)  Supramolecular metal-organic frameworks as host-guest nanoplatforms for versatile and customizable biomedical applications.  Acta Biomaterialia,  168  (617). 
2. Lin Yuan, Lizhen Liu, Zhi Mi, Meng Chen, Yunfeng Bai, Jun Qin, Feng Feng.  (2023)  A ratiometric sensor based on dual-emission carbon dots sensitive detection of amaranth.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  302  (123058). 
3. Yu Fang, Haiyan Cui, Xiaoqin Liang, Jianping Yu, Jianrong Wang, Guanghui Zhao.  (2022)  Quaternary Ammonium-Tethered Phenylboronic Acids Appended Supramolecular Nanomicelles as a Promising Bacteria Targeting Carrier for Nitric Oxide Delivery.  Polymers,  14  (20): (4451). 
4. Junlian Wang, Wen Xu, Jianguo Cui, Guodong Xu, Yufu Chen, Peilong Wang, Ziyong Chang.  (2023)  The role of β, γ, δ-substituent of dialkylphosphinic acids in HREE extraction and separation behaviors.  JOURNAL OF RARE EARTHS,  41  (1789). 
5. Yuan-Fu Ding, Jianwen Wei, Xingping Quan, Wenting Gu, Long Xi, Ying Zheng, Yonghua Zhao, Jingwei Luo, Shengke Li, Greta S.P. Mok, Ruibing Wang.  (2022)  Hyaluronic acid-based supramolecular medicine with polyamines sequestration capability for cooperative anti-psoriasis.  CARBOHYDRATE POLYMERS,  296  (119968). 
6. Jianhua He, Wenli Zhang, Xiaoju Zhou, Fengfei Xu, Jiahui Zou, Qiqi Zhang, Yi Zhao, Hongliang He, Hu Yang, Jianping Liu.  (2023)  Reactive oxygen species (ROS)-responsive size-reducible nanoassemblies for deeper atherosclerotic plaque penetration and enhanced macrophage-targeted drug delivery.  Bioactive Materials,  19  (115). 
7. Pengfei Ren, Dandan Wei, Xin Ge, Faming Wang, Min Liang, Jidong Dai, Li Xu, Tianzhu Zhang.  (2021)  Injectable supramolecular hydrogels based on host–guest interactions with cell encapsulation capabilities.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,  628  (127338). 
8. Chen Zhongyin, Liao Tao, Wan Lihui, Kuang Ying, Liu Chang, Duan Junlin, Xu Xiangyu, Xu Ziqiang, Jiang Bingbing, Li Cao.  (2021)  Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery.  Nano Research,  14  (11): (4264-4273). 
9. Hu Xiaohong, Gao Ziyu, Tan Huaping, Wang Huiming, Mao Xincheng, Pang Juan.  (2019)  An Injectable Hyaluronic Acid-Based Composite Hydrogel by DA Click Chemistry With pH Sensitive Nanoparticle for Biomedical Application.  Frontiers in Chemistry,  7   
10. Jiagen Li, Peng Liu.  (2018)  One-pot fabrication of pH/reduction dual-stimuli responsive chitosan-based supramolecular nanogels for leakage-free tumor-specific DOX delivery with enhanced anti-cancer efficacy.  CARBOHYDRATE POLYMERS,  201  (583). 
11. Guo-Feng Luo, Wei-Hai Chen, Qi Lei, Wen-Xiu Qiu, Yu-Xin Liu, Yin-Jia Cheng, Xian-Zheng Zhang.  (2016)  A Triple-Collaborative Strategy for High-Performance Tumor Therapy by Multifunctional Mesoporous Silica-Coated Gold Nanorods.  ADVANCED FUNCTIONAL MATERIALS,  26  (24): (4339-4350). 
12. Kongchang Wei, Meiling Zhu, Yuxin Sun, Jianbin Xu, Qian Feng, Sien Lin, Tianyi Wu, Jia Xu, Feng Tian, Jiang Xia, Gang Li, Liming Bian.  (2016)  Robust Biopolymeric Supramolecular “Host−Guest Macromer” Hydrogels Reinforced by in Situ Formed Multivalent Nanoclusters for Cartilage Regeneration.  MACROMOLECULES,  49  (3): (866–875). 
13. Shixiang Feng, Xu Zhang, Yanxiang Liu.  (2015)  New insights into the primary phototransformation of acetaminophen by UV/H2O2: photo-Fries rearrangement versus hydroxyl radical induced hydroxylation.  WATER RESEARCH,  86  (35). 
14. Junlian Wang, Guang Chen, Shengming Xu, Linyan Li.  (2015)  Synthesis of novel nonsymmetric dialkylphosphinic acid extractants and studies on their extraction–separation performance for heavy rare earths.  HYDROMETALLURGY,  154  (129). 
15. Zhao Zheng-bai, An Shuang-shuang, Xie Hai-jiao, Jiang Yong.  (2015)  Copolymerization and properties of multicomponent crosslinked hydrogels.  CHINESE JOURNAL OF POLYMER SCIENCE,  33  (1): (173-183). 
16. Tian-Tian Yao,Jing Wang,Yun-Fan Xue,Wei-Jiang Yu,Qiang Gao,Lino Ferreira,Ke-Feng Ren,Jian Ji.  (2019-08-23)  A photodynamic antibacterial spray-coating based on the host-guest immobilization of the photosensitizer methylene blue..  Journal of materials chemistry. B,  7  ((33)): (5089-5095). 
17. Yun-Dong Yin, Lei Yang, Xi-Tong Song, Jun Hu, Fang-Fang Chen, Ming Xu, Zhi-Yuan Gu.  (2024)  Determination of Acetylamantadine by γ-Cyclodextrin-Assisted α-HL Nanopore for Potential Cancer Prediagnosis.  ANALYTICAL CHEMISTRY,  96  (21): (8325-8331). 

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