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Alsterpaullone, 2-Cyanoethyl - ≥97%, high purity, Inhibitor of cyclin dependent kinase 1;Inhibitor of glycogen synthase kinase 3 beta

COA

Grade & Purity:

Moligand™

≥97%

In stock

Item Number

A336672

Grouped product items
SKU	Size	Availability	Price	Qty
A336672-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$304.90

a highly potent, ATP-competitive, selective inhibitor of Cdk1/cyclin B and GSK-3β.

View related series

cyclin dependent kinase 1 Inhibitor (46) glycogen synthase kinase 3 beta Inhibitor (44)

Basic Description

Synonyms	Alsterpaullone, 2-Cyanoethyl is also known as 3-(6-Oxo-9-nitro-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepin-2-yl)propionitrile.
Specifications & Purity	Moligand™, ≥97%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of cyclin dependent kinase 1;Inhibitor of glycogen synthase kinase 3 beta
Product Description	Alsterpaullone, 2-Cyanoethyl is an alsterpaullone derivative that acts as a highly potent, ATP-competitive, selective inhibitor of Cdk1/cyclin B and GSK-3β (IC50 = 230 pM and 800 pM, respectively; [ATP] = 15 μM). Alsterpaullone, 2-Cyanoethyl displays ~37-fold greater selectivity for Cdk1/cyclin B over Cdk5/p25 (IC50 = 30 nM). In a commercially available testing screen panel, Alsterpaullone, 2-Cyanoethyl was shown to inhibit other kinases (pIC50 = -logIC50[M]; pIC50 ~ 7.5, 7.0, 7.0, 6.5, 6.5, 6.0, and 6.0 for Cdk2/A, Cdk4/D1, GSK-3β, PDGFRβ, Src, VEGFR-2, and VEGFR-3, respectively; [ATP] = 1 μM).

Associated Targets(Human)

CDK1 Tchem Cyclin-dependent kinase 1 (1 Activities)

Discover Target: CDK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta (2 Activities)

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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