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(±)alpha-Methylserotonin maleate , CAS No.304-52-9(free basis), Agonist of 5-HT 1D receptor;Agonist of 5-ht 1e receptor;Agonist of 5-HT 1F receptor;Agonist of 5-HT 2A receptor;Agonist of 5-HT 2B receptor;Agonist of 5-HT 2C receptor;Agonist of 5-HT 4 receptor;Agonist of 5-HT 6 receptor

COA COA
In stock
Item Number
A338115
Grouped product items
SKU Size
Availability
 Price Qty
A338115-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$139.90
A338115-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$219.90
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Bulk Order  SDS  DATASHEET  Specification Sheet

a SR-2A, SR-2B, and SR-2C agonist

View related series
5-HT1D receptor Agonist (45) 5-ht1e receptor Agonist (26) 5-HT1F receptor Agonist (23) 5-HT2A receptor Agonist (39) 5-HT2B receptor Agonist (36) 5-HT2C receptor Agonist (33) 5-HT4 receptor Agonist (23) 5-HT6 receptor Agonist (27)

Basic Description

Synonyms 3-(2-Aminopropyl)-1H-indol-5-ol | (±)-α-Methyl-5-hydroxytryptamine | 5-Hydroxy-α-methyltryptamine | α-Methyl-5-hydroxytryptamine | α-Methylserotonin
Specifications & Purity Moligand™
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type AGONIST
Mechanism of action Agonist of 5-HT 1D receptor;Agonist of 5-ht 1e receptor;Agonist of 5-HT 1F receptor;Agonist of 5-HT 2A receptor;Agonist of 5-HT 2B receptor;Agonist of 5-HT 2C receptor;Agonist of 5-HT 4 receptor;Agonist of 5-HT 6 receptor
Product Description

(±)α-Methylserotonin maleate is a racemic mixture of α-Methylserotonin maleate and is a serotonin (SR) receptor agonist with preference for SR-2A, SR-2B, and SR-2C. (±)α-Methylserotonin maleate has been utilized in studies of aggression involving the central amygdaloid nucleus in female Wistar rats. Additional studies with frog spinal cord motoneurons in the presence of NMDA receptor open-channel blockers and high concentrations of α-methy-5-hydroxytryptamine indicated that these high concentrations significantly potentiated NMDA-induced depolarizations in these motoneurons.

α-Methylserotonin is a potent and selective agonist of 5-HT 2 receptor .α-Methylserotonin is an analogue of serotonin formed in vivo from α-methyltryptophan.α-Methylserotonin mediates the lymphatic smooth muscle contraction and prevents the up-regulation of serotonin-receptor-mediated phosphoinositide hydrolysis.

Associated Targets(Human)

HTR4 Tclin 5-hydroxytryptamine receptor 4 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR2A Tclin 5-hydroxytryptamine receptor 2A (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR1E Tchem 5-hydroxytryptamine receptor 1E (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR1D Tclin 5-hydroxytryptamine receptor 1D (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR1F Tclin 5-hydroxytryptamine receptor 1F (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR2C Tclin 5-hydroxytryptamine receptor 2C (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR1A Tclin 5-hydroxytryptamine receptor 1A (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR6 Tchem 5-hydroxytryptamine receptor 6 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR2B Tclin 5-hydroxytryptamine receptor 2B (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Names and Identifiers

Molecular Weight 306.31

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Solubility Soluble in water (10 mg/ml), and DMSO (100 mM).

Solution Calculators

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