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Alendronate sodium trihydrate - 10mM in Water, high purity , CAS No.121268-17-5

    Grade & Purity:
  • 10mM in Water
In stock
Item Number
A420924
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A420924-1ml
1ml
Available within 8-12 weeks(?)
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$69.90

Potent bone resorption inhibitor

Basic Description

Synonyms 121268-17-5 | Alendronate sodium trihydrate | Fosamax | Alendronate monosodium trihydrate | Alendronate sodium hydrate | Adronat | Alendros | Sodium alendronate | SODIUM ALENDRONATE TRIHYDRATE | 2UY4M2U3RA | CHEBI:2566 | Alendronic acid monosodium salt trihydrate | DTXSID7047801
Specifications & Purity 10mM in Water
Biochemical and Physiological Mechanisms Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC50 = 460 nM); CD45 protein tyrosine phosphatase inhibitor.Potent bone resorption inhibitor. Inhibits farnesyl synthase (IC 50 = 460 nM) and the isopre
Storage Temp Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

It's odorless and tasteless.Alendronate sodium trihydrate is a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor and CD45 protein tyrosine phosphatase inhibitor.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Organic phosphonic acids and derivatives
Subclass Bisphosphonates
Intermediate Tree Nodes Not available
Direct Parent Bisphosphonates
Alternative Parents Organic phosphonic acids  Organopnictogen compounds  Organophosphorus compounds  Organooxygen compounds  Organic zwitterions  Organic sodium salts  Organic oxides  Monoalkylamines  Hydrocarbon derivatives  
Molecular Framework Aliphatic acyclic compounds
Substituents Bisphosphonate - Organophosphonic acid - Organic alkali metal salt - Amine - Organic oxide - Hydrocarbon derivative - Organopnictogen compound - Organic sodium salt - Organic salt - Organic zwitterion - Primary amine - Organophosphorus compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Primary aliphatic amine - Organic nitrogen compound - Aliphatic acyclic compound
Description This compound belongs to the class of organic compounds known as bisphosphonates. These are organic compounds containing two phosphonate groups linked together through a carbon atoms.
External Descriptors hydrate - organic sodium salt

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name sodium;(4-amino-1-hydroxy-1-phosphonobutyl)-hydroxyphosphinate;trihydrate
INCHI InChI=1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1
InChIKey DCSBSVSZJRSITC-UHFFFAOYSA-M
Smiles C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.O.O.O.[Na+]
Isomeric SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.O.O.O.[Na+]
WGK Germany 3
RTECS SZ6523500
Molecular Weight 325.12
Reaxy-Rn 13434693
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13434693&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Sensitivity heat sensitive
Molecular Weight 325.120 g/mol
XLogP3
Hydrogen Bond Donor Count 8
Hydrogen Bond Acceptor Count 11
Rotatable Bond Count 5
Exact Mass 325.03 Da
Monoisotopic Mass 325.03 Da
Topological Polar Surface Area 167.000 Ų
Heavy Atom Count 18
Formal Charge 0
Complexity 293.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 5

Citations of This Product

1. Xin-Yue Yang, Dan-Dan Wu, Cong-Cong Zhuang, Chao-Mei Ma.  (2023)  Anti-osteoporosis effects of mammalian lignans and their precursors from flaxseed and safflower seed using zebrafish model.  JOURNAL OF FOOD SCIENCE,  88  (12): (5278-5290). 
2. Lu Tan, Menghuan Li, Hang Chen, Yuchen Zhang, Yuan Liu, Maohua Chen, Zhong Luo, Kaiyong Cai, Yan Hu.  (2023)  Dynamic hydrogel with environment-adaptive autonomous wound-compressing ability enables rapid hemostasis and inflammation amelioration for hemorrhagic wound healing.  Nano Today,  52  (101962). 
3. Shi Jiawei, Bai Xuemeng, Zheng Yahui, Che Jianfei, Xiao Yinghong.  (2023)  Sugarcane Stem Derived Hybrid Scaffold for Bone Tissue Engineering via Top-down Approach.  COMPOSITE INTERFACES,     
4. Wang Siqi, Jin Yao, Ai Wenhui, Wang Xiufeng, Zhang Zhiqing, Zhou Ting, Zhang Guodong, Wang Fang.  (2023)  H2O2 actuated molybdenum oxide nanodots: Multi-enzyme-like activities, leverage of Fenton reaction, and dual-mode sensitive detection of alendronate sodium.  Nano Research,  16  (10): (12106-12115). 
5. Kai Zhang, Junlong Da, Jianqun Wang, Lixue Liu, Xinpeng Liu, Haoze Yuan, Lili Jiang, Yawei Geng, Xiaoyao Liu, Zhuling Jiang, Han Jin, Ying Li, Bin Zhang.  (2022)  Multifunctional Alendronate-PEI Carbon Dots for the Treatment of Bone-Destructive Diseases via Bidirectional Regulation of Osteoblast-Osteoclast Function.  Advanced Therapeutics,  (2): (2200149). 
6. Juan Tan, Ping Deng, Li Wang, Xiaoya Bi, Yiyao Zhou, Yi Wang, Pu Zhang.  (2022)  Signal-on and selective detection of anti-tumor adjunctive drug zoledronic acid using fluorescent sulfur quantum dots.  DYES AND PIGMENTS,  205  (110520). 
7. Huang Xiuyu, Qiu Miaojuan, Wang Tianqi, Li Binbin, Zhang Shiqiang, Zhang Tianzhi, Liu Peng, Wang Qiang, Qian Zhi Rong, Zhu Chengming, Wu Meiying, Zhao Jing.  (2022)  Carrier-free multifunctional nanomedicine for intraperitoneal disseminated ovarian cancer therapy.  JOURNAL OF NANOBIOTECHNOLOGY,  20  (1): (1-15). 
8. Chunxiang Lin, Jinteng Chen, Zhihao Wu, Ruiyang Chi, Huiting Lin, Yifan Liu, Yuancai Lv, Xiaoxia Ye, Wei Luo.  (2022)  Phosphate-Functionalized Fibrous Adsorbent for Effectively Extracting Uranium from Seawater.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,  61  (5): (2227–2236). 
9. Yahui Zheng, Luyao Wang, Xuemeng Bai, Yinghong Xiao, Jianfei Che.  (2022)  Bio-inspired composite by hydroxyapatite mineralization on (bis)phosphonate-modified cellulose-alginate scaffold for bone tissue engineering.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,  635  (127958). 
10. Zhan Hao, Song Zhao, Qinghua Li, Yi Wang, Jun Zhang, Zhi Wang, Jixiao Wang.  (2021)  Reverse osmosis membranes with sulfonate and phosphate groups having excellent anti- scaling and anti-fouling properties.  DESALINATION,  509  (115076). 
11. Qianqian Han, Lirong Huang, Ying Wang, Shixin Sun, Hao Huang, Fei Li, Fangtian Wang, Ligen Chen, Hongmei Zhang, Yanqing Wang.  (2021)  Platinum (II)-coordinated Portulaca oleracea polysaccharides as metal-drug based polymers for anticancer study.  COLLOIDS AND SURFACES B-BIOINTERFACES,  201  (111628). 
12. Mengmeng Qin, Minghui Li, Ge Song, Canyu Yang, Peiyao Wu, Wenbing Dai, Hua Zhang, Xueqing Wang, Yiguang Wang, Demin Zhou, Bing He, Qiang Zhang.  (2021)  Boosting innate and adaptive antitumor immunity via a biocompatible and carrier-free nanovaccine engineered by the bisphosphonates-metal coordination.  Nano Today,  37  (101097). 
13. Yang Lei, Hu Yumin, Liu Yuanfen, Liu Yanyan, Miao Si, Li Zhen, Xu Bohui, Shen Yan.  (2020)  Preparation and in vitro evaluation of doxorubicin loaded alendronate modified hollow gold nanoparticles for bone-targeted chemo-photothermal therapy.  Materials Express,  10  (11): (1950-1959). 
14. Nani Wang, Pingcui Xu, Xuping Wang, Weixuan Yao, Binjie Wang, Yuanzhao Wu, Dan Shou.  (2020)  Timosaponin AIII attenuates inflammatory injury in AGEs-induced osteoblast and alloxan-induced diabetic osteoporosis zebrafish by modulating the RAGE/MAPK signaling pathways.  PHYTOMEDICINE,  75  (153247). 
15. Yingcong He, Ting Zhu, Lei Liu, Xuetao Shi, Zhengmei Lin.  (2018)  Modifying collagen with alendronate sodium for bone regeneration applications.  RSC Advances,  (30): (16762-16772). 
16. Xiao-Shui Li, Xi Chen, Bi-Feng Yuan, Yu-Qi Feng.  (2015)  Phosphonate-modified metal oxides for the highly selective enrichment of phosphopeptides.  RSC Advances,  (11): (7832-7841). 
17. Shao-Qi Fu,Zi-Yuan Wang,Zheng-Meng Jiang,Zhi-Ming Bi,E-Hu Liu.  (2020-03-20)  Integration of Zebrafish Model and Network Pharmacology to Explore Possible Action Mechanisms of Morinda officinalis for Treating Osteoporosis..  Chemistry & biodiversity,  17  ((5)): (e2000056-e2000056). 
18. Guoyu Yang, Jing Ye, Jingcheng Wang, Huijie Liu, Yanli Long, Junkai Jiang, Xinxin Miao, Jianjian Deng, Tianlong Wu, Tao Li, Xigao Cheng, Xiaolei Wang.  (2024)  “Three Birds, One Stone” Strategy of NIR-Responsive CO/H2S Dual-Gas Nanogenerator for Efficient Treatment of Osteoporosis.  Materials Today Bio,    (101179). 
19. Yubin Long, Yuan Ma, Houzhi Yang, Xiangbin Wang, Jigeng Fan, Yong Li, Bo Tao, Tianwei Sun.  (2024)  A bone-targeting delivery platform based on mesoporous silica loaded with piR7472 for the treatment of osteoporosis.  Arabian Journal of Chemistry,  17  (106040). 
20. Yanbin Zhao, Yangyang Li, Bin Wang, Junyan Yao, Yue Fan, Peng He, Jing Bai, Cheng Wang, Feng Xue, Chenglin Chu.  (2024)  An Injectable Magnesium-Based Cement Stimulated with NIR for Drug-Controlled Release and Osteogenic Potential.  Advanced Healthcare Materials,    (2400207). 
21. Kaitao Yao, Qian Zhang, Lian Weng, Shuyang Li, Xuzhou Zheng, Liqun Hu, Yuxi Luo, Xiaoyu Huang, Zhangfan Gong, Zi Wang, Chang Liu, Jiyuan Yan, Jianhua Ge, Xingtao Chen, Yiran Yin.  (2024)  Cerium-Doped, Alendronate-Loaded, Metal–Organic Framework Nanodrug for Delayed Osteoporosis Progress.  ACS Applied Nano Materials,  (24): (28504-28518). 
22. Huilian Huang, Sajid Asghar, Ling Lin, Su Chen, Chenjun Yuan, Muhui Sang, Yanyu Xiao.  (2025)  Design and evaluation of a multi-responsive dual-modality bone-targeted drug delivery vehicle for the treatment of osteosarcoma.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,    (125191). 
23. Wenqian Zhang, Shengming Zhang, Minghao He, Weixian Hu, Wenhao Han, Kangkang Zha, Qian Feng, Guohui Liu, Yanli Zhao, Bobin Mi.  (2024)  Ni-MOF Engineered System Targeting Macrophage Aurora A Kinase for Bone Loss Prevention Through PD-L1 Activation.  ADVANCED FUNCTIONAL MATERIALS,    (2413913). 

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