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| SKU | Size | Availability |
Price | Qty |
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A420924-1ml
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1ml |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$69.90
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Potent bone resorption inhibitor
| Synonyms | 121268-17-5 | Alendronate sodium trihydrate | Fosamax | Alendronate monosodium trihydrate | Alendronate sodium hydrate | Adronat | Alendros | Sodium alendronate | SODIUM ALENDRONATE TRIHYDRATE | 2UY4M2U3RA | CHEBI:2566 | Alendronic acid monosodium salt trihydrate | DTXSID7047801 |
|---|---|
| Specifications & Purity | 10mM in Water |
| Biochemical and Physiological Mechanisms | Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC50 = 460 nM); CD45 protein tyrosine phosphatase inhibitor.Potent bone resorption inhibitor. Inhibits farnesyl synthase (IC 50 = 460 nM) and the isopre |
| Storage Temp | Store at -80°C |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Product Description |
It's odorless and tasteless.Alendronate sodium trihydrate is a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor and CD45 protein tyrosine phosphatase inhibitor. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Class | Organic phosphonic acids and derivatives |
| Subclass | Bisphosphonates |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Bisphosphonates |
| Alternative Parents | Organic phosphonic acids Organopnictogen compounds Organophosphorus compounds Organooxygen compounds Organic zwitterions Organic sodium salts Organic oxides Monoalkylamines Hydrocarbon derivatives |
| Molecular Framework | Aliphatic acyclic compounds |
| Substituents | Bisphosphonate - Organophosphonic acid - Organic alkali metal salt - Amine - Organic oxide - Hydrocarbon derivative - Organopnictogen compound - Organic sodium salt - Organic salt - Organic zwitterion - Primary amine - Organophosphorus compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Primary aliphatic amine - Organic nitrogen compound - Aliphatic acyclic compound |
| Description | This compound belongs to the class of organic compounds known as bisphosphonates. These are organic compounds containing two phosphonate groups linked together through a carbon atoms. |
| External Descriptors | hydrate - organic sodium salt |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| IUPAC Name | sodium;(4-amino-1-hydroxy-1-phosphonobutyl)-hydroxyphosphinate;trihydrate |
|---|---|
| INCHI | InChI=1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1 |
| InChIKey | DCSBSVSZJRSITC-UHFFFAOYSA-M |
| Smiles | C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.O.O.O.[Na+] |
| Isomeric SMILES | C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.O.O.O.[Na+] |
| WGK Germany | 3 |
| RTECS | SZ6523500 |
| Molecular Weight | 325.12 |
| Reaxy-Rn | 13434693 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13434693&ln= |
| Sensitivity | heat sensitive |
|---|---|
| Molecular Weight | 325.120 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 8 |
| Hydrogen Bond Acceptor Count | 11 |
| Rotatable Bond Count | 5 |
| Exact Mass | 325.03 Da |
| Monoisotopic Mass | 325.03 Da |
| Topological Polar Surface Area | 167.000 Ų |
| Heavy Atom Count | 18 |
| Formal Charge | 0 |
| Complexity | 293.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 5 |
| 1. Xin-Yue Yang, Dan-Dan Wu, Cong-Cong Zhuang, Chao-Mei Ma. (2023) Anti-osteoporosis effects of mammalian lignans and their precursors from flaxseed and safflower seed using zebrafish model. JOURNAL OF FOOD SCIENCE, 88 (12): (5278-5290). |
| 2. Lu Tan, Menghuan Li, Hang Chen, Yuchen Zhang, Yuan Liu, Maohua Chen, Zhong Luo, Kaiyong Cai, Yan Hu. (2023) Dynamic hydrogel with environment-adaptive autonomous wound-compressing ability enables rapid hemostasis and inflammation amelioration for hemorrhagic wound healing. Nano Today, 52 (101962). |
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| 8. Chunxiang Lin, Jinteng Chen, Zhihao Wu, Ruiyang Chi, Huiting Lin, Yifan Liu, Yuancai Lv, Xiaoxia Ye, Wei Luo. (2022) Phosphate-Functionalized Fibrous Adsorbent for Effectively Extracting Uranium from Seawater. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 61 (5): (2227–2236). |
| 9. Yahui Zheng, Luyao Wang, Xuemeng Bai, Yinghong Xiao, Jianfei Che. (2022) Bio-inspired composite by hydroxyapatite mineralization on (bis)phosphonate-modified cellulose-alginate scaffold for bone tissue engineering. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 635 (127958). |
| 10. Zhan Hao, Song Zhao, Qinghua Li, Yi Wang, Jun Zhang, Zhi Wang, Jixiao Wang. (2021) Reverse osmosis membranes with sulfonate and phosphate groups having excellent anti- scaling and anti-fouling properties. DESALINATION, 509 (115076). |
| 11. Qianqian Han, Lirong Huang, Ying Wang, Shixin Sun, Hao Huang, Fei Li, Fangtian Wang, Ligen Chen, Hongmei Zhang, Yanqing Wang. (2021) Platinum (II)-coordinated Portulaca oleracea polysaccharides as metal-drug based polymers for anticancer study. COLLOIDS AND SURFACES B-BIOINTERFACES, 201 (111628). |
| 12. Mengmeng Qin, Minghui Li, Ge Song, Canyu Yang, Peiyao Wu, Wenbing Dai, Hua Zhang, Xueqing Wang, Yiguang Wang, Demin Zhou, Bing He, Qiang Zhang. (2021) Boosting innate and adaptive antitumor immunity via a biocompatible and carrier-free nanovaccine engineered by the bisphosphonates-metal coordination. Nano Today, 37 (101097). |
| 13. Yang Lei, Hu Yumin, Liu Yuanfen, Liu Yanyan, Miao Si, Li Zhen, Xu Bohui, Shen Yan. (2020) Preparation and in vitro evaluation of doxorubicin loaded alendronate modified hollow gold nanoparticles for bone-targeted chemo-photothermal therapy. Materials Express, 10 (11): (1950-1959). |
| 14. Nani Wang, Pingcui Xu, Xuping Wang, Weixuan Yao, Binjie Wang, Yuanzhao Wu, Dan Shou. (2020) Timosaponin AIII attenuates inflammatory injury in AGEs-induced osteoblast and alloxan-induced diabetic osteoporosis zebrafish by modulating the RAGE/MAPK signaling pathways. PHYTOMEDICINE, 75 (153247). |
| 15. Yingcong He, Ting Zhu, Lei Liu, Xuetao Shi, Zhengmei Lin. (2018) Modifying collagen with alendronate sodium for bone regeneration applications. RSC Advances, 8 (30): (16762-16772). |
| 16. Xiao-Shui Li, Xi Chen, Bi-Feng Yuan, Yu-Qi Feng. (2015) Phosphonate-modified metal oxides for the highly selective enrichment of phosphopeptides. RSC Advances, 5 (11): (7832-7841). |
| 17. Shao-Qi Fu,Zi-Yuan Wang,Zheng-Meng Jiang,Zhi-Ming Bi,E-Hu Liu. (2020-03-20) Integration of Zebrafish Model and Network Pharmacology to Explore Possible Action Mechanisms of Morinda officinalis for Treating Osteoporosis.. Chemistry & biodiversity, 17 ((5)): (e2000056-e2000056). |
| 18. Guoyu Yang, Jing Ye, Jingcheng Wang, Huijie Liu, Yanli Long, Junkai Jiang, Xinxin Miao, Jianjian Deng, Tianlong Wu, Tao Li, Xigao Cheng, Xiaolei Wang. (2024) “Three Birds, One Stone” Strategy of NIR-Responsive CO/H2S Dual-Gas Nanogenerator for Efficient Treatment of Osteoporosis. Materials Today Bio, (101179). |
| 19. Yubin Long, Yuan Ma, Houzhi Yang, Xiangbin Wang, Jigeng Fan, Yong Li, Bo Tao, Tianwei Sun. (2024) A bone-targeting delivery platform based on mesoporous silica loaded with piR7472 for the treatment of osteoporosis. Arabian Journal of Chemistry, 17 (106040). |
| 20. Yanbin Zhao, Yangyang Li, Bin Wang, Junyan Yao, Yue Fan, Peng He, Jing Bai, Cheng Wang, Feng Xue, Chenglin Chu. (2024) An Injectable Magnesium-Based Cement Stimulated with NIR for Drug-Controlled Release and Osteogenic Potential. Advanced Healthcare Materials, (2400207). |
| 21. Kaitao Yao, Qian Zhang, Lian Weng, Shuyang Li, Xuzhou Zheng, Liqun Hu, Yuxi Luo, Xiaoyu Huang, Zhangfan Gong, Zi Wang, Chang Liu, Jiyuan Yan, Jianhua Ge, Xingtao Chen, Yiran Yin. (2024) Cerium-Doped, Alendronate-Loaded, Metal–Organic Framework Nanodrug for Delayed Osteoporosis Progress. ACS Applied Nano Materials, 7 (24): (28504-28518). |
| 22. Huilian Huang, Sajid Asghar, Ling Lin, Su Chen, Chenjun Yuan, Muhui Sang, Yanyu Xiao. (2025) Design and evaluation of a multi-responsive dual-modality bone-targeted drug delivery vehicle for the treatment of osteosarcoma. INTERNATIONAL JOURNAL OF PHARMACEUTICS, (125191). |
| 23. Wenqian Zhang, Shengming Zhang, Minghao He, Weixian Hu, Wenhao Han, Kangkang Zha, Qian Feng, Guohui Liu, Yanli Zhao, Bobin Mi. (2024) Ni-MOF Engineered System Targeting Macrophage Aurora A Kinase for Bone Loss Prevention Through PD-L1 Activation. ADVANCED FUNCTIONAL MATERIALS, (2413913). |