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Aldosterone - 99%, high purity , CAS No.52-39-1, Agonist of Mineralocorticoid receptor

COA COA
    Grade & Purity:
  • ≥99%
In stock
Item Number
A299444
Grouped product items
SKU Size
Availability
 Price Qty
A299444-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$183.90
A299444-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$649.90
A299444-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,299.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
Endogenous Metabolite (959) inhibitor (73) Ketones (57) Metabolic Enzyme/Protease (4860) Metabolite (5307) Steroid hormone (4)

Basic Description

Synonyms 11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al | delta-Aldosterone | 11beta,21-Dihydroxy-3,20-diketo-4-pregnen-18-al | GTPL2872 | 11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al | ALDOSTERONE [MART.] | MLS001333164 | NCGC00164236-01 | 11-beta,21-Dihydroxy-3,20
Specifications & Purity ≥99%
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type AGONIST
Mechanism of action Agonist of Mineralocorticoid receptor
Product Description

Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Lipids and lipid-like molecules
Class Steroids and steroid derivatives
Subclass Hydroxysteroids
Intermediate Tree Nodes Not available
Direct Parent 21-hydroxysteroids
Alternative Parents Gluco/mineralocorticoids, progestogins and derivatives  20-oxosteroids  3-oxo delta-4-steroids  11-beta-hydroxysteroids  Delta-4-steroids  Cyclohexenones  Alpha-hydroxy ketones  Secondary alcohols  Cyclic alcohols and derivatives  Primary alcohols  Organic oxides  Hydrocarbon derivatives  Aldehydes  
Molecular Framework Aliphatic homopolycyclic compounds
Substituents Progestogin-skeleton - 21-hydroxysteroid - 20-oxosteroid - Pregnane-skeleton - 18-oxosteroid - 3-oxo-delta-4-steroid - 3-oxosteroid - Oxosteroid - 11-beta-hydroxysteroid - 11-hydroxysteroid - Delta-4-steroid - Cyclohexenone - Cyclic alcohol - Alpha-hydroxy ketone - Ketone - Secondary alcohol - Cyclic ketone - Alcohol - Hydrocarbon derivative - Organooxygen compound - Organic oxide - Organic oxygen compound - Carbonyl group - Primary alcohol - Aldehyde - Aliphatic homopolycyclic compound
Description This compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
External Descriptors C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives

Associated Targets(Human)

NR3C2 Tclin Mineralocorticoid receptor (7 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SERPINA6 Tchem Corticosteroid-binding globulin (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NR3C2 Tclin Mineralocorticoid receptor (2134 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CSNK1D Tchem Casein kinase I delta (4546 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SERPINA6 Tchem Corticosteroid binding globulin (274 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U2OS (164939 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UGT2B7 Tchem UDP-glucuronosyltransferase 2B7 (787 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Skin (286 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSD17B7 Tchem 3-keto-steroid reductase (330 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UGT1A1 Tchem UDP-glucuronosyltransferase 1-1 (448 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BRPF1 Tchem Peregrin (2217 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Abcb1b P-glycoprotein 1 (174 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Shbg Testis-specific androgen-binding protein (10 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
H4 (48 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slc22a5 Solute carrier family 22 member 5 (44 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slco1a1 Solute carrier organic anion transporter family member 1A1 (265 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Abcb1a P-glycoprotein 1 and 3 (MDR1a/MDR1b) (23 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
INCHI InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1
InChIKey PQSUYGKTWSAVDQ-ZVIOFETBSA-N
Smiles CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C=O)O
Isomeric SMILES C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C=O)O
Alternate CAS 52-39-1,6251-69-0
NSC Number 73856
MeSH Entry Terms Aldosterone;Aldosterone, (+-)-Isomer;Aldosterone, (11 beta,17 alpha)-Isomer
Molecular Weight 360.44
Reaxy-Rn 2065875
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2065875&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

14 results found

Lot Number Certificate Type Date Item
C2504480 Certificate of Analysis Feb 14, 2025 A299444
C2504482 Certificate of Analysis Feb 14, 2025 A299444
C2504481 Certificate of Analysis Feb 14, 2025 A299444
K2303036 Certificate of Analysis Oct 25, 2024 A299444
K2303037 Certificate of Analysis Oct 25, 2024 A299444
K2303038 Certificate of Analysis Oct 25, 2024 A299444
J2417390 Certificate of Analysis Sep 26, 2024 A299444
J2417388 Certificate of Analysis Sep 26, 2024 A299444
J2417389 Certificate of Analysis Sep 26, 2024 A299444
H2427369 Certificate of Analysis Aug 17, 2024 A299444
H2427384 Certificate of Analysis Aug 17, 2024 A299444
H2427411 Certificate of Analysis Aug 17, 2024 A299444
E2429145 Certificate of Analysis May 14, 2024 A299444
E2431273 Certificate of Analysis May 14, 2024 A299444

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Chemical and Physical Properties

Solubility Soluble in ethanol, chloroform, glycols, vegetable oils, acetone, ether, and methanol. Insoluble in water.
Molecular Weight 360.400 g/mol
XLogP3 1.100
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 3
Exact Mass 360.194 Da
Monoisotopic Mass 360.194 Da
Topological Polar Surface Area 91.700 Ų
Heavy Atom Count 26
Formal Charge 0
Complexity 682.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 7
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

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    Aldosterone standard
    • 100 μg/mL in acetonitrile

    Starting at $687.90

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