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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
|
A648564-5mg
|
5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$85.90
|
|
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A648564-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$145.90
|
|
|
A648564-25mg
|
25mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$300.90
|
|
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A648564-50mg
|
50mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$485.90
|
|
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A648564-100mg
|
100mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$780.90
|
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| Specifications & Purity | ≥98% |
|---|---|
| Biochemical and Physiological Mechanisms | ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC 50 of 0.63 µM and a K i of 0.46 µM. ALDH1A3-IN-1 can be studied in prostate cancer. |
| Storage Temp | Protected from light,Store at -80°C |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Product Description |
ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC 50 of 0.63 µM and a K i of 0.46 µM. ALDH1A3-IN-1 can be studied in prostate cancer In Vitro ALDH1A3-IN-1 (Compound 14) (0-200 µM, 96 h) shows antiproliferative activity in prostate cancer cell lines. ALDH1A3-IN-1 (0-200 µM, 72 h) reduces cell viability of primary prostate cells in a dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: PC3, LNCaP, and DU145 cells Concentration: 12.5-200 µM Incubation Time: 96 h Result: Showed antiproliferative activity with IC 50 values of 47 ± 6, 25 ± 1, and 61 ± 5 µM against PC3, LNCaP, and DU145 cells. Cell Viability AssayCell Line: Primary cells cultured at early passage from human prostate tissue biopsies Concentration: 50 and 200 μM Incubation Time: 72 h Result: Resulted a dose-dependent reduction in percentage cell viability of primary prostate epithelial cultures. Form:Liquid IC50& Target:ALDH1A3 0.63 μM (IC 50 ) ALDH1A1 7.08 μM (IC 50 ) ALDH3A1 8.00 μM (IC 50 ) ALDH1A3 0.46 μM (Ki) ALDH1A3 26.92 μM (Km) |
| Smiles | O=CC1=CC(Br)=C(C=C1)N(CCC)CCC |
|---|---|
| Molecular Weight | 284.19 |