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AL082D06 - 99%, high purity , CAS No.256925-03-8

COA

Grade & Purity:

≥99%

Cas Number: 256925-03-8
Molecular Weight: 409.91
PubChem CID: 9822799
PubChem SID: 504764914

In stock

Item Number

A413545

Grouped product items
SKU	Size	Availability	Price
A413545-2mg	2mg	2	$25.90
A413545-5mg	5mg	3	$53.90
A413545-25mg	25mg	2	$205.90
A413545-50mg	50mg	2	$358.90
A413545-100mg	100mg	2	$478.90

Glucocorticoid Receptor Antagonists

View related series

Glucocorticoid Receptor (103) Immunology/Inflammation (1929) Vitamin D Related/Nuclear Receptor (907)

Basic Description

Synonyms	AL 082D06(D-06) \| MFCD00100145 \| AKOS026750194 \| HY-15709 \| FT-0700273 \| s6608 \| A911349 \| D 06 \| SCHEMBL6556764 \| AL-082D06; AL 082D06;D06;D 06; D-06 \| AL082D06 \| AL-082D06 \| EX-A877 \| 4,4'-((2-chloro-5-nitrophenyl)methylene)bis(N,N-dimethylaniline) \| J-
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information AL082D06 AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins. Targets Glucocorticoid receptor 210 nM(Ki) In vitro D06 can antagonize steroid-mediated induction of glutamine synthetase RNA in MG63 cells and TAT enzyme in human skin fibroblasts. It can act to inhibit both transcriptional activation and repression by receptor in a variety of cell types on a variety of genes. D06 partially blocks glucocorticoid receptor (GR) translocation to the nucleus, and completely blocks DNA binding by the receptor.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Triphenyl compounds

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Triphenyl compounds
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Triphenyl compounds
Alternative Parents	Nitrobenzenes Nitroaromatic compounds Dialkylarylamines Aniline and substituted anilines Chlorobenzenes Aryl chlorides Propargyl-type 1,3-dipolar organic compounds Organic oxoazanium compounds Organochlorides Organic salts Organic oxides Hydrocarbon derivatives Organic cations
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Triphenyl compound - Nitrobenzene - Nitroaromatic compound - Aniline or substituted anilines - Dialkylarylamine - Tertiary aliphatic/aromatic amine - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Organic nitro compound - C-nitro compound - Tertiary amine - Organic 1,3-dipolar compound - Organic oxoazanium - Allyl-type 1,3-dipolar organic compound - Propargyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Organic salt - Amine - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organic cation - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as triphenyl compounds. These are aromatic compounds containing a triphenyl moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

SLC2A1 Tchem Glucose transporter (14755 Activities)

Discover Target: SLC2A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504764914
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504764914
IUPAC Name	4-[(2-chloro-5-nitrophenyl)-[4-(dimethylamino)phenyl]methyl]-N,N-dimethylaniline
INCHI	InChI=1S/C23H24ClN3O2/c1-25(2)18-9-5-16(6-10-18)23(17-7-11-19(12-8-17)26(3)4)21-15-20(27(28)29)13-14-22(21)24/h5-15,23H,1-4H3
InChIKey	IPICUXHYPAMJNC-UHFFFAOYSA-N
Smiles	CN(C)C1=CC=C(C=C1)C(C2=CC=C(C=C2)N(C)C)C3=C(C=CC(=C3)[N+](=O)[O-])Cl
Isomeric SMILES	CN(C)C1=CC=C(C=C1)C(C2=CC=C(C=C2)N(C)C)C3=C(C=CC(=C3)[N+](=O)[O-])Cl
Molecular Weight	409.91
Reaxy-Rn	11688930
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11688930&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
G2206044	Certificate of Analysis	Apr 03, 2025	A413545
G2206043	Certificate of Analysis	Apr 03, 2025	A413545
G2206042	Certificate of Analysis	Apr 03, 2025	A413545
G2206041	Certificate of Analysis	Apr 03, 2025	A413545
G2206045	Certificate of Analysis	Apr 03, 2025	A413545
G2201041	Certificate of Analysis	Jun 04, 2022	A413545

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 10 mg/mL (24.39 mM); Water: Insoluble; Ethanol: Insoluble;
Molecular Weight	409.900 g/mol
XLogP3	6.000
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	409.156 Da
Monoisotopic Mass	409.156 Da
Topological Polar Surface Area	52.300 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	495.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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