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AFM-30a hydrochloride - 99%, high purity , CAS No.A659162

COA

Grade & Purity:

≥99%

Molecular Weight: 502.97

In stock

Item Number

A659162

Grouped product items
SKU	Size	Availability	Price
A659162-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$200.90
A659162-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$620.90
A659162-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$980.90

View related series

Epigenetics (1496) Histone Modification (1379) Protein Arginine Deiminase (14)

Basic Description

Specifications & Purity	≥99%
Storage Temp	Store at 2-8°C,Protected from light,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	AFM-30a hydrochloride is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a hydrochloride binds to PAD2 with an EC 50 value of 9.5 μM. AFM-30a hydrochloride also inhibits H3 citrullination with an EC 50 valu Appearance:Solid IC50& Target:EC50: 9.5 μM (PAD2); 0.4 μM (H3 citrullination) In Vitro:AFM-30a hydrochloride (compound 30a; 25 μM) has good potency to enter HEK293T/PAD2 cells and covalent modify PAD2 with an EC 50 of 9.5 μM. AFM-30a hydrochloride shows good ability to inhibit H3 citrullination with an EC 50 of 0.4 μM. MCE has not In Vivo:AFM-30a hydrochloride suppresses NLRP3 signaling and decreases airway remodeling in PAD2 -/- transgenic mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Biological Activity:AFM-30a hydrochloride is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a hydrochloride binds to PAD2 with an EC 50 value of 9.5 μM. AFM-30a hydrochloride also inhibits H3 citrullination with an EC 50 valu

Names and Identifiers

Smiles	O=C(C1=C2C(NCC2=CC=C1)=O)N[C@H](C3=NC4=C(N3C)C=CC=C4OC)CCCNC(CF)=N.[H]Cl
Molecular Weight	502.97

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 50 mg/mL (99.41 mM; ultrasonic and warming and heat to 60°C) H2O : 50 mg/mL (99.41 mM; Need ultrasonic)

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