JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

This is a demo store. No orders will be fulfilled.

Account

Settings

Language

྾

Home
Small Molecules & Compound Libraries
Signaling Pathways
Metabolic Enzyme/Protease
HIF/HIF Prolyl-Hydroxylase
Adaptaquin - ≥97%(HPLC), high purity , CAS No.385786-48-1

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Adaptaquin - ≥97%(HPLC), high purity , CAS No.385786-48-1

COA

Grade & Purity:

≥97%(HPLC)

Cas Number: 385786-48-1
Molecular Weight: 377.82
PubChem CID: 3740671

In stock

Item Number

A287760

Grouped product items
SKU	Size	Availability	Price
A287760-5mg	5mg	3	$58.90
A287760-10mg	10mg	3	$98.90
A287760-25mg	25mg	3	$197.90
A287760-50mg	50mg	3	$315.90
A287760-100mg	100mg	3	$494.90

HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant

View related series

Glucose Metabolism (1943) HIF/HIF Prolyl-Hydroxylase (128) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms	7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol
Specifications & Purity	≥97%(HPLC)
Biochemical and Physiological Mechanisms	HIF-prolyl hydroxylase-2 (PHD2) inhibitor. Blocks glutamate induced ROS production in HT-22 cells, independent of MnSOD. Exhibits neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 de
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Product introduction A cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Quinolines and derivatives
    - Subclass 8-hydroxyquinolines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Quinolines and derivatives
Subclass	8-hydroxyquinolines
Intermediate Tree Nodes	Not available
Direct Parent	8-hydroxyquinolines
Alternative Parents	Hydroxypyridines Chlorobenzenes Aminopyridines and derivatives 1-hydroxy-4-unsubstituted benzenoids Imidolactams Aryl chlorides Heteroaromatic compounds Azacyclic compounds Organooxygen compounds Organochlorides Hydrocarbon derivatives Amines
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	8-hydroxyquinoline - Aminopyridine - Chlorobenzene - Halobenzene - Phenol - Hydroxypyridine - 1-hydroxy-4-unsubstituted benzenoid - Monocyclic benzene moiety - Imidolactam - Benzenoid - Pyridine - Aryl chloride - Aryl halide - Heteroaromatic compound - Azacycle - Organochloride - Organohalogen compound - Amine - Organic nitrogen compound - Hydrocarbon derivative - Organooxygen compound - Organic oxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as 8-hydroxyquinolines. These are compounds containing a quinoline moiety, which carries a hydroxy group at the 8-position. Quinoline consists of a benzene ring fused to a pyrimidine ring to form benzo[b]azabenzene.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

Trypanosoma brucei brucei (13300 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	7-[(4-chlorophenyl)-[(3-hydroxypyridin-2-yl)amino]methyl]quinolin-8-ol
INCHI	InChI=1S/C21H16ClN3O2/c22-15-8-5-14(6-9-15)18(25-21-17(26)4-2-12-24-21)16-10-7-13-3-1-11-23-19(13)20(16)27/h1-12,18,26-27H,(H,24,25)
InChIKey	KKYHNYRUBSYTCZ-UHFFFAOYSA-N
Smiles	C1=CC2=C(C(=C(C=C2)C(C3=CC=C(C=C3)Cl)NC4=C(C=CC=N4)O)O)N=C1
Isomeric SMILES	C1=CC2=C(C(=C(C=C2)C(C3=CC=C(C=C3)Cl)NC4=C(C=CC=N4)O)O)N=C1
Molecular Weight	377.82
Reaxy-Rn	21535920
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=21535920&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
H2205667	Certificate of Analysis	May 12, 2025	A287760
H2205668	Certificate of Analysis	May 12, 2025	A287760
H2205669	Certificate of Analysis	May 12, 2025	A287760
H2205670	Certificate of Analysis	May 12, 2025	A287760
H2205671	Certificate of Analysis	May 12, 2025	A287760

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 37.78, Max Conc. mM: 100
Molecular Weight	377.800 g/mol
XLogP3	4.500
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	377.093 Da
Monoisotopic Mass	377.093 Da
Topological Polar Surface Area	78.300 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	474.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.