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ACHP - ≥97%(HPLC), high purity , CAS No.406208-42-2

COA COA
    Grade & Purity:
  • ≥97%(HPLC)
In stock
Item Number
A288136
Grouped product items
SKU Size
Availability
 Price Qty
A288136-1mg
1mg
3
$48.90
A288136-5mg
5mg
3
$187.90
A288136-10mg
10mg
3
$287.90
A288136-25mg
25mg
3
$647.90
A288136-50mg
50mg
2
$1,165.90
A288136-100mg
100mg
2
$2,098.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Selective IKKα and IKKβ inhibitor

View related series
Apoptosis (4276)

Basic Description

Synonyms 2-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(4-piperidinyl)-3-pyridine-carbonitrile | 2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-piperidin-4-ylpyridine-3-carbonitrile | 2-Amino-6-[2-(cyclopropylmethoxy)-6-oxo-2,4-cyclohexadien-1-ylidene
Specifications & Purity ≥97%(HPLC)
Biochemical and Physiological Mechanisms IκB kinase inhibitor (IC50values are 8.5 and 250 nM for IKKβand IKKαrespectively). Selective for IKKαand IKKβover IKK3, Syk and MAPKKK4 (IC50values are > 20μM). Inhibits DNA binding activity of NF-κB. Blocks NF-κB pathway in multiple myeloma cell lines; i
Storage Temp Protected from light,Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

product description：

A cell-permeable piperidinyl-pyridine compound that acts as a selective inhibitor of IKK-2 activity (IC50 = 8.5 and 250 nM for IKK-2 and IKK-1, respectively) with little effect towards IKK-3, Syk, and MKK4 (IC50 >20 µM). Exhibits good aqueous solubility (0.12 mg/ml in pH 7.4 isotonic buffer) and potent activity in various cellular assays in vitro (IC50<150 nM). Shown to be orally bioavailable both in rats and mice (BA = 60% and 16%, respectively) and effectively inhibit arachidonic acid-induced swelling in a murine ear edema model in vivo.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Pyridines and derivatives
Subclass Phenylpyridines
Intermediate Tree Nodes Not available
Direct Parent Phenylpyridines
Alternative Parents 3-pyridinecarbonitriles  Phenol ethers  Phenoxy compounds  1-hydroxy-2-unsubstituted benzenoids  1-hydroxy-4-unsubstituted benzenoids  Alkyl aryl ethers  Aminopyridines and derivatives  Aralkylamines  Imidolactams  Piperidines  Heteroaromatic compounds  Dialkylamines  Azacyclic compounds  Nitriles  Primary amines  Hydrocarbon derivatives  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents 2-phenylpyridine - Phenoxy compound - Phenol ether - 3-pyridinecarbonitrile - Alkyl aryl ether - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Aminopyridine - Phenol - Aralkylamine - Monocyclic benzene moiety - Imidolactam - Benzenoid - Piperidine - Heteroaromatic compound - Secondary aliphatic amine - Ether - Carbonitrile - Nitrile - Azacycle - Secondary amine - Organic oxygen compound - Amine - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Cyanide - Organic nitrogen compound - Primary amine - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond.
External Descriptors Not available

Associated Targets(Human)

IKBKB Tchem Inhibitor of nuclear factor kappa-B kinase subunit beta (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CHUK Tchem Inhibitor of nuclear factor kappa B kinase alpha subunit (3170 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IKBKB Tchem Inhibitor of nuclear factor kappa B kinase beta subunit (5554 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SYK Tclin Tyrosine-protein kinase SYK (7372 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IKBKE Tchem Inhibitor of nuclear factor kappa B kinase epsilon subunit (3311 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK293 (82097 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HUVEC (11049 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Jurkat (10389 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PBMC (10003 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-piperidin-4-ylpyridine-3-carbonitrile
INCHI InChI=1S/C21H24N4O2/c22-11-16-15(14-6-8-24-9-7-14)10-17(25-21(16)23)20-18(26)2-1-3-19(20)27-12-13-4-5-13/h1-3,10,13-14,24,26H,4-9,12H2,(H2,23,25)
InChIKey DYVFBWXIOCLHPP-UHFFFAOYSA-N
Smiles C1CC1COC2=CC=CC(=C2C3=NC(=C(C(=C3)C4CCNCC4)C#N)N)O
Isomeric SMILES C1CC1COC2=CC=CC(=C2C3=NC(=C(C(=C3)C4CCNCC4)C#N)N)O
Molecular Weight 364.44
Reaxy-Rn 9812205
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9812205&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number Certificate Type Date Item
L2312213 Certificate of Analysis Dec 01, 2023 A288136
L2312214 Certificate of Analysis Dec 01, 2023 A288136
L2312394 Certificate of Analysis Dec 01, 2023 A288136
L2312397 Certificate of Analysis Dec 01, 2023 A288136
L2312225 Certificate of Analysis Dec 01, 2023 A288136
L2312226 Certificate of Analysis Dec 01, 2023 A288136
L2312227 Certificate of Analysis Dec 01, 2023 A288136
L2312228 Certificate of Analysis Dec 01, 2023 A288136
L2312395 Certificate of Analysis Dec 01, 2023 A288136
L2312217 Certificate of Analysis Dec 01, 2023 A288136
L2312229 Certificate of Analysis Dec 01, 2023 A288136
L2312393 Certificate of Analysis Dec 01, 2023 A288136

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Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 7.29, Max Conc. mM: 20
Sensitivity Light sensitive
Molecular Weight 364.400 g/mol
XLogP3 2.900
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 5
Exact Mass 364.19 Da
Monoisotopic Mass 364.19 Da
Topological Polar Surface Area 104.000 Ų
Heavy Atom Count 27
Formal Charge 0
Complexity 540.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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