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ABX464 - 99%, high purity , Cap binding complex modulator, CAS No.1258453-75-6, Cap binding complex modulator

COA

Grade & Purity:

Moligand™

≥99%

Cas Number: 1258453-75-6
Molecular Weight: 338.71
PubChem CID: 49846599
PubChem SID: 504770948

In stock

Item Number

A412163

Grouped product items
SKU	Size	Availability	Price
A412163-5mg	5mg	3	$112.90
A412163-25mg	25mg	3	$395.90
A412163-100mg	100mg	2	$1,013.90
A412163-250mg	250mg	2	$2,281.90

HIV Inhibitors

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Anti-infection (2803) HIV (254) Virus (1811)

Basic Description

Synonyms	26RU378B9V \| HY-100870 \| UNII-26RU378B9V \| Abx 464 \| OBEFAZIMOD [INN] \| ABX464(ABX-464;ABX 464) \| B1833 \| WHO 12112 \| 1258453-75-6 \| S0076 \| SB18690 \| Z3041496912 \| BS-14770 \| SPL-464 \| 8-Chloro-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine \| ABX464 \| AB
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	ABX464 (SPL-464) is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	MODULATOR
Mechanism of action	Cap binding complex modulator
Product Description	Information ABX464 ABX464 (SPL-464) is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM. Targets HIV-1 (Cell-free assay); HIV-1 (Cell-free assay) 0.1 μM; 0.5 μM

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Quinolines and derivatives
    - Subclass Aminoquinolines and derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Quinolines and derivatives
Subclass	Aminoquinolines and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Aminoquinolines and derivatives
Alternative Parents	Chloroquinolines Aniline and substituted anilines Phenoxy compounds Phenol ethers Aminopyridines and derivatives Aryl chlorides Imidolactams Heteroaromatic compounds Trihalomethanes Azacyclic compounds Secondary amines Hydrocarbon derivatives Organooxygen compounds Alkyl fluorides Organochlorides Organofluorides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Aminoquinoline - Haloquinoline - Chloroquinoline - Phenoxy compound - Phenol ether - Aniline or substituted anilines - Aminopyridine - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Pyridine - Benzenoid - Imidolactam - Heteroaromatic compound - Trihalomethane - Secondary amine - Azacycle - Organic nitrogen compound - Organonitrogen compound - Organofluoride - Organochloride - Organohalogen compound - Amine - Alkyl halide - Alkyl fluoride - Organic oxygen compound - Halomethane - Hydrocarbon derivative - Organooxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as aminoquinolines and derivatives. These are organic compounds containing an amino group attached to a quinoline ring system.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	6.889
hba_count	2
HBD Count	1
Rotatable Bond	4

Associated Targets(Human)

HEK293 (82097 Activities)

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Associated Targets(non-human)

Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504770948
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504770948
IUPAC Name	8-chloro-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine
INCHI	InChI=1S/C16H10ClF3N2O/c17-13-3-1-2-10-4-9-14(22-15(10)13)21-11-5-7-12(8-6-11)23-16(18,19)20/h1-9H,(H,21,22)
InChIKey	OZOGDCZJYVSUBR-UHFFFAOYSA-N
Smiles	C1=CC2=C(C(=C1)Cl)N=C(C=C2)NC3=CC=C(C=C3)OC(F)(F)F
Isomeric SMILES	C1=CC2=C(C(=C1)Cl)N=C(C=C2)NC3=CC=C(C=C3)OC(F)(F)F
Molecular Weight	338.71
Reaxy-Rn	20975254
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20975254&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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Analytical Chart:

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4 results found

Lot Number	Certificate Type	Date	Item
G2228263	Certificate of Analysis	May 09, 2025	A412163
G2228264	Certificate of Analysis	May 09, 2025	A412163
G2228374	Certificate of Analysis	May 09, 2025	A412163
G2228261	Certificate of Analysis	May 09, 2025	A412163

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 68 mg/mL (200.76 mM); Ethanol: 68 mg/mL (200.76 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility	68
DMSO(mM) Max Solubility	200.761713560273
Water(mg / mL) Max Solubility	＜1
Molecular Weight	338.710 g/mol
XLogP3	5.900
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	338.043 Da
Monoisotopic Mass	338.043 Da
Topological Polar Surface Area	34.200 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	388.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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ABX464 - 99%, high purity , Cap binding complex modulator, CAS No.1258453-75-6, Cap binding complex modulator

Basic Description

Taxonomic Classification

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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