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Basic Description
| Synonyms | 2-HYDROXYISOBUTYRIC ACID | 594-61-6 | 2-Methyllactic acid | 2-Hydroxy-2-methylpropanoic acid | Acetonic acid | alpha-Hydroxyisobutyric acid | 2-Hydroxy-2-methylpropionic acid | Hydroxydimethylacetic acid | Lactic acid, 2-methyl- | Propanoic acid, 2-hydroxy-2-methyl- | alpha- |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Storage Temp | Store at -80°C |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Product Description |
α-Hydroxyisobutyric acid (2-hydroxyisobutyric acid) is the building block for polymer synthesis. It forms complexes with Eu(III) and has been studied by time resolved fluorescence spectroscopy Application 2-Hydroxyisobutyric acid is used as an electrolyte in the separation of the metal ions by on-line cyclic voltammetry. It is also used as a building block for the synthesis of polymers. Its conjugate base, 2-hydroxybutyrate is utilized to catabolize L-threonine as well as synthesize glutathione. Further, it is used as an indicator for the early detection insulin resistance in non-diabetic subjects. |
Taxonomic Classification
Taxonomy Tree
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Kingdom
Organic compounds
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Superclass
Organic acids and derivatives
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Class
Hydroxy acids and derivatives
- Subclass Alpha hydroxy acids and derivatives
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Class
Hydroxy acids and derivatives
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Superclass
Organic acids and derivatives
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Class | Hydroxy acids and derivatives |
| Subclass | Alpha hydroxy acids and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Alpha hydroxy acids and derivatives |
| Alternative Parents | Tertiary alcohols Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aliphatic acyclic compounds |
| Substituents | Alpha-hydroxy acid - Tertiary alcohol - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Alcohol - Aliphatic acyclic compound |
| Description | This compound belongs to the class of organic compounds known as alpha hydroxy acids and derivatives. These are organic compounds containing a carboxylic acid substituted with a hydroxyl group on the adjacent carbon. |
| External Descriptors | Hydroxy fatty acids |
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Associated Targets(Human)
AR
Tclin
Androgen Receptor (11781 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
TSHR
Tclin
Thyroid stimulating hormone receptor (29986 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ALDH1A1
Tchem
Aldehyde dehydrogenase 1A1 (77053 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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APEX1
Tchem
DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 2-hydroxy-2-methylpropanoic acid |
|---|---|
| INCHI | InChI=1S/C4H8O3/c1-4(2,7)3(5)6/h7H,1-2H3,(H,5,6) |
| InChIKey | BWLBGMIXKSTLSX-UHFFFAOYSA-N |
| Smiles | CC(C)(C(=O)O)O |
| Isomeric SMILES | CC(C)(C(=O)O)O |
| WGK Germany | 3 |
| Molecular Weight | 104.1 |
| Beilstein | 1744739 |
| Reaxy-Rn | 1744739 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1744739&ln= |
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Sensitivity | Moisture sensitive. |
|---|---|
| Boil Point(°C) | 84 °C/1.5 mmHg |
| Melt Point(°C) | 76-80°C |
| Molecular Weight | 104.100 g/mol |
| XLogP3 | -0.400 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 104.047 Da |
| Monoisotopic Mass | 104.047 Da |
| Topological Polar Surface Area | 57.500 Ų |
| Heavy Atom Count | 7 |
| Formal Charge | 0 |
| Complexity | 84.900 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
Citations of This Product
| 1. Shuai Yuan, Mingyong Zhou, Xijiang Liu, Bingyan Jiang. (2023) Effect of pressure-driven flow on electroosmotic flow and electrokinetic mass transport in microchannels. INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 206 (123925). |
| 2. Ting Song, Piyong Zhang, Jian Zeng, Tingting Wang, Atif Ali, Heping Zeng. (2017) In Situ Construction of Globe-like Carbon Nitride as a Self-Cocatalyst Modified Tree-like Carbon Nitride for Drastic Improvement in Visible-Light Photocatalytic Hydrogen Evolution. ChemCatChem, 9 (21): (4035-4042). |
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