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A 83-01 - ≥98%, high purity , CAS No.909910-43-6

COA

Grade & Purity:

≥98%

Cas Number: 909910-43-6
Molecular Weight: 421.52
MDL number: MFCD08705403
PubChem CID: 16218924
PubChem SID: 504768380

In stock

Item Number

A274862

Grouped product items
SKU	Size	Availability	Price
A274862-1mg	1mg	4	$19.90
A274862-5mg	5mg	2	$39.90
A274862-10mg	10mg	5	$59.90
A274862-25mg	25mg	5	$119.90
A274862-50mg	50mg	4	$189.90
A274862-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$299.90

Potent ALK4, 5 and 7 kinase inhibitor

View related series

Anaplastic lymphoma kinase (ALK) (52) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260) TGF-beta/Smad (303) TGF-β Receptor (70)

Basic Description

Synonyms	A83-01 \| A-83-01 \| 4-chloro-5-iodo-pyrrolo[2,3-d]pyrimidine \| GS-4197 \| Q26998219 \| (trans-3-aminocyclobutyl)methanol \| EC-000.2376 \| NCGC00165721-02 \| Stemolecule A83-01 \| HY-10432 \| FT-0746646 \| MFCD08705403 \| NCGC00165721-16 \| 1H-Pyrazole-1-carbothioam
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Potent, selective TGF-β type I receptor ALK5, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 kinase inhibitor (IC 50 values are 12, 45 and 7.5 nM for ALK5, ALK4 and ALK7 respectively). Active in vivo and in vitro . A 83-01 is a TGFβ kin
Source	Synthetic
Storage Temp	Protected from light,Store at -20°C,Argon charged,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively。

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Quinolines and derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Quinolines and derivatives
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Quinolines and derivatives
Alternative Parents	Methylpyridines Benzene and substituted derivatives Pyrazoles Heteroaromatic compounds Azacyclic compounds Organosulfur compounds Organonitrogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Quinoline - Methylpyridine - Benzenoid - Pyridine - Monocyclic benzene moiety - Heteroaromatic compound - Pyrazole - Azole - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organosulfur compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as quinolines and derivatives. These are compounds containing a quinoline moiety, which consists of a benzene ring fused to a pyrimidine ring to form benzo[b]azabenzene.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TGFBR1 Tchem TGF-beta receptor type I (3786 Activities)

Discover Target: TGFBR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

YES1 Tclin Tyrosine-protein kinase YES (2781 Activities)

Discover Target: YES1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U2OS (164939 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK-293T (167025 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TGFB1 Tbio Transforming growth factor beta (1 Activities)

Discover Target: TGFB1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504768380
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504768380
IUPAC Name	3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide
INCHI	InChI=1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31)
InChIKey	HIJMSZGHKQPPJS-UHFFFAOYSA-N
Smiles	CC1=NC(=CC=C1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5
Isomeric SMILES	CC1=NC(=CC=C1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5
Molecular Weight	421.52
Reaxy-Rn	15627575
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=15627575&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

15 results found

Lot Number	Certificate Type	Date	Item
F2505065	Certificate of Analysis	Jun 11, 2025	A274862
F2325177	Certificate of Analysis	May 09, 2024	A274862
F2325168	Certificate of Analysis	May 09, 2024	A274862
F2325166	Certificate of Analysis	May 09, 2024	A274862
F2325163	Certificate of Analysis	May 09, 2024	A274862
F2325169	Certificate of Analysis	Apr 11, 2024	A274862
L2426129	Certificate of Analysis	Apr 03, 2024	A274862
F2325172	Certificate of Analysis	Apr 03, 2024	A274862
F2325176	Certificate of Analysis	Apr 03, 2024	A274862
B2208033	Certificate of Analysis	Aug 10, 2023	A274862
B2208126	Certificate of Analysis	Aug 10, 2023	A274862
B2208150	Certificate of Analysis	Aug 10, 2023	A274862
B2208147	Certificate of Analysis	Aug 10, 2023	A274862
B2208146	Certificate of Analysis	Nov 15, 2022	A274862
B2208148	Certificate of Analysis	Nov 15, 2022	A274862

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Chemical and Physical Properties

Solubility	Soluble in DMSO；Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly)
Sensitivity	Moisture Sensitive,Heat Sensitive
Molecular Weight	421.500 g/mol
XLogP3	5.000
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	421.136 Da
Monoisotopic Mass	421.136 Da
Topological Polar Surface Area	87.700 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	609.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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