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TGF_beta_Smad
TGF-β Receptor
A 77-01 - 98%, high purity , CAS No.607737-87-1

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A 77-01 - 98%, high purity , CAS No.607737-87-1

COA

Grade & Purity:

≥98%

Cas Number: 607737-87-1
Molecular Weight: 286.33
PubChem CID: 10469233

In stock

Item Number

A288900

Grouped product items
SKU	Size	Availability	Price
A288900-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$141.90
A288900-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$212.90
A288900-25mg	25mg	3	$479.90
A288900-50mg	50mg	3	$862.90
A288900-100mg	100mg	2	$1,552.90
A288900-200mg	200mg	2	$2,794.90
A288900-500mg	500mg	2	$6,288.90

Potent inhibitor of TGF-βRI

View related series

TGF-beta/Smad (303) TGF-β Receptor (70)

Basic Description

Synonyms	A 77-01 \| A-77-01 \| A77-01 \| AKOS026750350 \| DTXSID80440480 \| E98766 \| NCGC00379015-02 \| BCP13726 \| EX-A2200 \| MS-24090 \| C18H14N4 \| SCHEMBL17559240 \| 4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quinoline \| 4-[3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]qu
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Potent TGF-βRI (ALK-5) inhibitor (IC50= 34 nM). Inhibits TGF-β transcriptional activation. Inhibits TGF-β-induced proliferation of lung epithelial cells and SMAD phosphorylation. Inhibits TGF-β-induced epithelial-to-mesenchymal transition (EMT). Also inh
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Quinolines and derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Quinolines and derivatives
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Quinolines and derivatives
Alternative Parents	Methylpyridines Benzenoids Pyrazoles Heteroaromatic compounds Azacyclic compounds Organonitrogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Quinoline - Methylpyridine - Benzenoid - Pyridine - Heteroaromatic compound - Pyrazole - Azole - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as quinolines and derivatives. These are compounds containing a quinoline moiety, which consists of a benzene ring fused to a pyrimidine ring to form benzo[b]azabenzene.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TGFBR1 Tchem TGF-beta receptor type-1 (2 Activities)

Discover Target: TGFBR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK14 Tchem MAP kinase p38 alpha (12866 Activities)

Discover Target: MAPK14

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TGFBR1 Tchem TGF-beta receptor type I (3786 Activities)

Discover Target: TGFBR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline
INCHI	InChI=1S/C18H14N4/c1-12-5-4-8-17(21-12)18-15(11-20-22-18)13-9-10-19-16-7-3-2-6-14(13)16/h2-11H,1H3,(H,20,22)
InChIKey	KJTYZDORHCDZPS-UHFFFAOYSA-N
Smiles	CC1=NC(=CC=C1)C2=C(C=NN2)C3=CC=NC4=CC=CC=C34
Isomeric SMILES	CC1=NC(=CC=C1)C2=C(C=NN2)C3=CC=NC4=CC=CC=C34
Molecular Weight	286.33
Reaxy-Rn	32705446
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32705446&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number	Certificate Type	Date	Item
C2321095	Certificate of Analysis	Jan 03, 2023	A288900
C2321155	Certificate of Analysis	Jan 03, 2023	A288900
C2321096	Certificate of Analysis	Jan 03, 2023	A288900
C2321211	Certificate of Analysis	Jan 03, 2023	A288900
C2321092	Certificate of Analysis	Jan 03, 2023	A288900
C2321093	Certificate of Analysis	Jan 03, 2023	A288900
C2321094	Certificate of Analysis	Jan 03, 2023	A288900

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 28.63, Max Conc. mM: 100; Solvent:1eq. HCl, Max Conc. mg/mL: 14.32, Max Conc. mM: 50
Molecular Weight	286.300 g/mol
XLogP3	3.100
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Exact Mass	286.122 Da
Monoisotopic Mass	286.122 Da
Topological Polar Surface Area	54.500 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	374.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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