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A 1120 - 98%, high purity , CAS No.1152782-19-8, Inhibitor of retinol binding protein 4

COA COA
In stock
Item Number
A288923
Grouped product items
SKU Size
Availability
 Price Qty
A288923-10mg
10mg
2
$177.90
A288923-50mg
50mg
2
$642.90
A288923-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,157.90
A288923-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$2,604.90
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High affinity retinol-binding protein 4 (RBP4) ligand

View related series
Neuronal Signaling (3320) retinol binding protein 4 Inhibitor (1) Transthyretin (TTR) (13)

Basic Description

Synonyms GTPL8792 | HY-107633 | A 1120 | 2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid | NCGC00370977-01 | BDBM50019040 | 2T1 | A1120 | A-1120 | CWB78219 | 2-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido) benzoic acid | AKOS
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms High affinity retinol-binding protein 4 (RBP4) ligand (Ki= 8.3 nM); non-retinoid. Selective against a range of different cellular targets. As efficacious asfenretinide in the reduction of serum RBP4 and retinol. Displaces transthyretin (TTR) from RBP4-TTR
Storage Temp Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of retinol binding protein 4

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Piperidines
Subclass Phenylpiperidines
Intermediate Tree Nodes Not available
Direct Parent Phenylpiperidines
Alternative Parents Trifluoromethylbenzenes  N-phenylureas  Piperidinecarboxamides  Benzoic acids  Benzoyl derivatives  Vinylogous amides  Ureas  Azacyclic compounds  Carboxylic acids  Monocarboxylic acids and derivatives  Hydrocarbon derivatives  Organic oxides  Carbonyl compounds  Organofluorides  Organonitrogen compounds  Organopnictogen compounds  Alkyl fluorides  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Phenylpiperidine - N-phenylurea - Trifluoromethylbenzene - Benzoic acid or derivatives - Benzoic acid - 1-piperidinecarboxamide - Piperidinecarboxamide - Benzoyl - Benzenoid - Monocyclic benzene moiety - Vinylogous amide - Urea - Carbonic acid derivative - Azacycle - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Alkyl fluoride - Organohalogen compound - Organofluoride - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Alkyl halide - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as phenylpiperidines. These are compounds containing a phenylpiperidine skeleton, which consists of a piperidine bound to a phenyl group.
External Descriptors Not available

Associated Targets(Human)

RBP4 Tchem Retinol-binding protein 4 (8 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RBP4 Tchem Plasma retinol-binding protein (718 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Liver microsome (341 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504769984
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504769984
IUPAC Name 2-[[4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonyl]amino]benzoic acid
INCHI InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27)
InChIKey MEAQCLPMSVEOQF-UHFFFAOYSA-N
Smiles C1CN(CCC1C2=CC=CC=C2C(F)(F)F)C(=O)NC3=CC=CC=C3C(=O)O
Isomeric SMILES C1CN(CCC1C2=CC=CC=C2C(F)(F)F)C(=O)NC3=CC=CC=C3C(=O)O
Molecular Weight 392.37
Reaxy-Rn 24701600
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24701600&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
H2205673 Certificate of Analysis May 13, 2025 A288923
H2205675 Certificate of Analysis May 12, 2025 A288923
H2205672 Certificate of Analysis May 12, 2025 A288923
C2524041 Certificate of Analysis Jun 13, 2022 A288923
H2205674 Certificate of Analysis Jun 13, 2022 A288923

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 39.24, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 9.81, Max Conc. mM: 25
Molecular Weight 392.400 g/mol
XLogP3 4.300
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 3
Exact Mass 392.135 Da
Monoisotopic Mass 392.135 Da
Topological Polar Surface Area 69.600 Ų
Heavy Atom Count 28
Formal Charge 0
Complexity 561.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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