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9-Phenanthrol - 10mM in DMSO, high purity , CAS No.484-17-3, Channel blocker of TRPM4
Basic Description
Synonyms
Phenanthren-9-ol | 9-PHENANTHROL | 484-17-3 | 9-Hydroxyphenanthrene | 9-Phenanthrenol | NSC 50554 | CHEBI:28820 | 9FYU45OV9H | CHEMBL2407182 | DTXSID9047592 | 9-Hydroxyphenanthrene; NSC 50554 | MFCD00082298 | NSC-50554 | CCRIS 1840 | EINECS 207-602-4 | UNII-9FYU45OV9H | BRN 2047057 | phen
Specifications & Purity
Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms
Selective TRPM4 blocker (IC 50 = 20 μM). Modulates smooth muscle contraction. Reduces LPS-induced cell death. Promotes angiogenesis. Shows cardioprotective and anti-ischemic effects in vivo.
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
CHANNEL BLOCKER
Mechanism of action
Channel blocker of TRPM4
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Benzenoids
Class
Phenanthrenes and derivatives
Subclass
Phenanthrols
Intermediate Tree Nodes
Not available
Direct Parent
Phenanthrols
Alternative Parents
Naphthols and derivatives 1-hydroxy-2-unsubstituted benzenoids Organooxygen compounds Hydrocarbon derivatives
Molecular Framework
Aromatic homopolycyclic compounds
Substituents
Phenanthrol - 1-naphthol - 2-naphthol - Naphthalene - 1-hydroxy-2-unsubstituted benzenoid - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic homopolycyclic compound
Description
This compound belongs to the class of organic compounds known as phenanthrols. These are compounds containing a phenanthrene (or its hydrogenated derivative) to which a hydroxyl group is attached.
External Descriptors
phenanthrol
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
phenanthren-9-ol
INCHI
InChI=1S/C14H10O/c15-14-9-10-5-1-2-6-11(10)12-7-3-4-8-13(12)14/h1-9,15H
InChIKey
DZKIUEHLEXLYKM-UHFFFAOYSA-N
Smiles
C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)O
Isomeric SMILES
C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)O
WGK Germany
3
RTECS
SF8288000
PubChem CID
10229
Molecular Weight
194.23
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Molecular Weight
194.230 g/mol
XLogP3
3.600
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
1
Rotatable Bond Count
0
Exact Mass
194.073 Da
Monoisotopic Mass
194.073 Da
Topological Polar Surface Area
20.200 Ų
Heavy Atom Count
15
Formal Charge
0
Complexity
225.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
Citations of This Product
1.
Chun-Ying Xu, Yuan-Yuan Cui, Cheng-Xiong Yang.
(2024)
Fabrication of magnetic Fe3O4 doped β-cyclodextrin microporous organic network for the efficient extraction of endocrine disrupting chemicals from food takeaway boxes. JOURNAL OF CHROMATOGRAPHY A,
1715
(464625).
2.
Kai Hu, Tiantian Pang, Cheng Yang, Pengzhao Han, Lixin Li, Pan Wang, Zhenqiang Zhang, Wenjie Zhao, Shusheng Zhang.
(2023)
Simultaneous extraction of hydroxylated polycyclic aromatic hydrocarbons and catecholamines with magnetic boronic acid hypercrosslinked polymers. JOURNAL OF CHROMATOGRAPHY A,
1712
(464491).
3.
Zhengwen Wei, Yifan Du, Xiang-fei Lü, Wei Wang, Roberta Del Sole, Giuseppe Mele, Zhen-Yi Jiang.
(2023)
High-performance Fe3O4-terephthalaldehyde magnetic-nanocomposite for removal phenanthrene and 9-phenanthrol: A comprehensive experimental and theoretical analysis. SEPARATION AND PURIFICATION TECHNOLOGY,
306
(122610).
4.
Zhengwen Wei, Xiang-fei Lü, Wei Wang, Giuseppe Mele, Zhen-Yi Jiang.
(2023)
Excellent removal performance of 4,4'-biphenyldicarboxaldehyde m-phenylenediamine Schiff base magnetic polymer towards phenanthrene and 9-phenanthrol: Experimental, modeling and DFT calculations studies. JOURNAL OF HAZARDOUS MATERIALS,
441
(129920).
5.
Zhengwen Wei, Xiang-fei Lü, Wei Wang, Giuseppe Mele, Zhen-Yi Jiang.
(2022)
Fe3O4-4,4′-biphenyldicarboxaldehyde superparamagnetic-nanomaterial for the high-efficiency removal of 9-phenanthrol: experimental combined with DFT investigations. Environmental Science-Nano,
9
(9):
(3562-3580).
6.
Sun Fei, Feng Chao, Wang Yang, Yang Xue, Zhao Hong.
(2022)
Preparation of fluorescent polystyrene microspheres by improving swelling performance based on molecular weight and surface carboxyl group content. QUIMICA NOVA,
45
(2):
(145-151).
7.
Xin-Qiao He, Yuan-Yuan Cui, Cheng-Xiong Yang.
(2021)
Thiol–Yne Click Postsynthesis of a Sulfonate Group-Enriched Magnetic Microporous Organic Network for Efficient Extraction of Benzimidazole Fungicides. ACS Applied Materials & Interfaces,
13
(33):
(39905–39914).
8.
Xin-Qiao He, Yuan-Yuan Cui, Xiao-Hui Lin, Cheng-Xiong Yang.
(2021)
Fabrication of polyethyleneimine modified magnetic microporous organic network nanosphere for efficient enrichment of non-steroidal anti-inflammatory drugs from wastewater samples prior to HPLC-UV analysis. TALANTA,
233
(122471).
9.
Fan Libing, Ma Qianli, Tian Jiao, Li Dan, Xi Xue, Dong Xiangting, Yu Wensheng, Wang Jinxian, Liu Guixia.
(2019)
Conjugate Electrospinning Construction of Microyarns with Synchronous Color-Tuned Photoluminescence and Tunable Electrical Conductivity. JOURNAL OF ELECTRONIC MATERIALS,
48
(3):
(1511-1521).
10.
Cholho Choe, Ling Yang, Zhanao Lv, Wanling Mo, Zhuqi Chen, Guangxin Li, Guochuan Yin,.
(2015-04-24)
Redox-inactive metal ions promoted the catalytic reactivity of non-heme manganese complexes towards oxygen atom transfer.. Dalton transactions (Cambridge, England : 2003),
44
((19)):
( 9182-9192 ).
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10 Citations