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| SKU | Size | Availability |
Price | Qty |
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B274678-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$95.90
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Cell permeable cGMP analog. PKG activator.
| Synonyms | AC-25835 | 8-Bromo-cGMP (sodium) | 8-Bromoguanosine cyclic 3',5'-monophosphate sodium salt | 8-Br-cGMP | 8-Bromoguanosine 3',5'-cyclic monophosphate sodium salt, >=98% (HPLC), powder | CHEBI:64104 | sodium 8-bromo-3',5'-cyclic GMP | Guanosine 3',5'-cyclic |
|---|---|
| Specifications & Purity | ≥95% |
| Biochemical and Physiological Mechanisms | Cell permeable cGMP analog. PKG activator. Increases Ca 2+ levels and active in vivo . |
| Storage Temp | Store at -20°C,Desiccated |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description |
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Nucleosides, nucleotides, and analogues |
| Class | Purine nucleotides |
| Subclass | Cyclic purine nucleotides |
| Intermediate Tree Nodes | Not available |
| Direct Parent | 3',5'-cyclic purine nucleotides |
| Alternative Parents | Pentose phosphates Glycosylamines 6-oxopurines Hypoxanthines Monosaccharide phosphates Aminopyrimidines and derivatives Pyrimidones Aryl bromides N-substituted imidazoles Organic phosphoric acids and derivatives Vinylogous amides Tetrahydrofurans Heteroaromatic compounds Secondary alcohols Organic metal halides Oxacyclic compounds Azacyclic compounds Organic sodium salts Organic oxides Primary amines Hydrocarbon derivatives Organic zwitterions Organobromides Organopnictogen compounds |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | 3',5'-cyclic purine ribonucleotide - Pentose phosphate - Glycosyl compound - N-glycosyl compound - 6-oxopurine - Hypoxanthine - Monosaccharide phosphate - Imidazopyrimidine - Purine - Aminopyrimidine - Pyrimidone - Aryl bromide - Aryl halide - Monosaccharide - Pyrimidine - N-substituted imidazole - Organic phosphoric acid derivative - Heteroaromatic compound - Azole - Vinylogous amide - Imidazole - Tetrahydrofuran - Secondary alcohol - Oxacycle - Azacycle - Organic metal halide - Organic alkali metal salt - Organoheterocyclic compound - Organooxygen compound - Organic oxide - Alcohol - Organic zwitterion - Organic salt - Organic nitrogen compound - Organopnictogen compound - Organic oxygen compound - Primary amine - Organic sodium salt - Organohalogen compound - Organobromide - Amine - Organonitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as 3',5'-cyclic purine nucleotides. These are purine nucleotides in which the oxygen atoms linked to the C3 and C5 carbon atoms of the ribose moiety are both bonded the same phosphorus atom of the phosphate group. |
| External Descriptors | organic sodium salt |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| IUPAC Name | sodium;9-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-8-bromo-1H-purin-6-one |
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| INCHI | InChI=1S/C10H11BrN5O7P.Na/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5-2(22-8)1-21-24(19,20)23-5;/h2,4-5,8,17H,1H2,(H,19,20)(H3,12,14,15,18);/q;+1/p-1/t2-,4-,5-,8-;/m1./s1 |
| InChIKey | ZJRFCXHKYQVNFK-YEOHUATISA-M |
| Smiles | C1C2C(C(C(O2)N3C4=C(C(=O)NC(=N4)N)N=C3Br)O)OP(=O)(O1)[O-].[Na+] |
| Isomeric SMILES | C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=C(C(=O)NC(=N4)N)N=C3Br)O)OP(=O)(O1)[O-].[Na+] |
| Molecular Weight | 446.08 |
| Reaxy-Rn | 26171677 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26171677&ln= |
| Solubility | Soluble in water to 50 mM |
|---|---|
| Molecular Weight | 446.080 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 1 |
| Exact Mass | 444.94 Da |
| Monoisotopic Mass | 444.94 Da |
| Topological Polar Surface Area | 173.000 Ų |
| Heavy Atom Count | 25 |
| Formal Charge | 0 |
| Complexity | 657.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 4 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |