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7-Amino-4-methylcoumarin - ≥99%(HPLC),laser grade, high purity , CAS No.26093-31-2

In stock
Item Number
A109916
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Price Qty
A109916-100mg
100mg
5
$13.90
A109916-500mg
500mg
2
$56.90
A109916-1g
1g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$98.90

Fluorescent labeling reagent

Basic Description

Synonyms Sodium n-dodecyl sulfate | AM9859 | C47M2 | 7-Amino-4-methylcoumarin, 99% | 7-amino-4-methylcoumarine | 7-Amino-4-methylcoumarin - CAS 26093-31-2 | DB08168 | STK290900 | FT-0621348 | HMS547P13 | M0760 | Maybridge1_002279 | C10H9NO2 | HMS3604G16 | NSC 4579
Specifications & Purity laser grade, ≥99%(HPLC)
Biochemical and Physiological Mechanisms Fluorescent probe to analyse glycoproteins' monosaccharides and N-linked oligosaccharides. Antibacterial and antifungal agent in vitro . Used for spectrophotometric determination of small amounts of nitrite.
Storage Temp Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade laser grade
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Coumarins and derivatives
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Coumarins and derivatives
Alternative Parents 1-benzopyrans  Pyranones and derivatives  Benzenoids  Heteroaromatic compounds  Lactones  Oxacyclic compounds  Primary amines  Organopnictogen compounds  Organooxygen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Coumarin - Benzopyran - 1-benzopyran - Pyranone - Pyran - Benzenoid - Heteroaromatic compound - Lactone - Oxacycle - Organoheterocyclic compound - Amine - Hydrocarbon derivative - Organic oxide - Primary amine - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as coumarins and derivatives. These are polycyclic aromatic compounds containing a 1-benzopyran moiety with a ketone group at the C2 carbon atom (1-benzopyran-2-one).
External Descriptors 7-aminocoumarins

Associated Targets(Human)

CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA1 Tclin Carbonic anhydrase I (13240 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLA Tclin Alpha-galactosidase A (5444 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CASP1 Tchem Caspase-1 (6235 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CASP7 Tchem Caspase-7 (3146 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA12 Tclin Carbonic anhydrase XII (6231 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UGT1A4 Tbio UDP-glucuronosyltransferase 1A4 (288 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA9 Tclin Carbonic anhydrase IX (8255 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-29 (80576 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U-937 (7138 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
T47D (39041 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HBL-100 (746 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
WiDr (1835 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HeLa (62764 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ATG4B Tchem Cysteine protease ATG4B (985 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Cruzipain (33337 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
B16-F10 (4610 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hsf1 Heat shock factor protein 1 (5445 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504756115
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504756115
IUPAC Name 7-amino-4-methylchromen-2-one
INCHI InChI=1S/C10H9NO2/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5H,11H2,1H3
InChIKey GLNDAGDHSLMOKX-UHFFFAOYSA-N
Smiles CC1=CC(=O)OC2=C1C=CC(=C2)N
Isomeric SMILES CC1=CC(=O)OC2=C1C=CC(=C2)N
WGK Germany 3
Molecular Weight 175.18
Beilstein 142231
Reaxy-Rn 142231
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=142231&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
B2514028 Certificate of Analysis Feb 17, 2025 A109916
I1629004 Certificate of Analysis May 09, 2024 A109916
E2006043 Certificate of Analysis Jan 30, 2024 A109916
G1202020 Certificate of Analysis Mar 13, 2023 A109916
B2325313 Certificate of Analysis Mar 02, 2023 A109916

Chemical and Physical Properties

Sensitivity Light sensitive.
Melt Point(°C) 223-226°C
Molecular Weight 175.180 g/mol
XLogP3 1.600
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 0
Exact Mass 175.063 Da
Monoisotopic Mass 175.063 Da
Topological Polar Surface Area 52.300 Ų
Heavy Atom Count 13
Formal Charge 0
Complexity 260.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

1. Qitong Mao, Siqi Liu, Yangkai Xiong, Daxiong Hu, Lei Huang, Zhiqiang Fang, Hao Jiang, Haomin Wang, Jipeng Li, Shuhong Mao, Guoqing Wang.  (2023)  Advanced Marine Antifouling Hydrogels Based on 7-Amino-4-methylcoumarin Fluorescence Driven by Rare-Earth Phosphorescence.  ACS Applied Materials & Interfaces,  15  (49): (57582–57592). 
2. Xueping Quan, Bing Yan.  (2023)  In Situ Generated Dye@MOF/COF Heterostructure for Fluorescence Detection of Chloroquine Phosphate and Folic Acid via Different Luminescent Channels.  ACS Applied Materials & Interfaces,  15  (47): (54634–54642). 
3. Shunyu Xiang, Xiaoyan Wang, Shiqi Peng, Xinke Kang, Jing Wang, Liyuan Peng, Xiaozhou Ma, Jin Huang, Xianchao Sun.  (2023)  Washout-Resistant, pH-Responsive Anti-TMV Nanoimmune Inducer Based on Cellulose Nanocrystals.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  71  (44): (16542–16553). 
4. Zhang Weina, Wang Mingzhu, Song Zhiwei, Fu Qianzheng, Chen Jiayu, Zhang Weitao, Gao Shuai, Sun Xiaoxiang, Yang Guang, Zhang Qiang, Yang Jiaqing, Tang Huanyin, Wang Haiyan, Kou Xiaochen, Wang Hong, Mao Zhiyong, Xu Xiaojun, Gao Shaorong, Jiang Ying.  (2023)  Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer.  Nature Communications,  14  (1): (1-17). 
5. Xinyu Zhao, Shujuan Yang, Furui He, Haifang Liu, Keyang Mai, Junhao Huang, Gaobo Yu, Yuhong Feng, Jiacheng Li.  (2023)  Light-dimerization telechelic alginate-based amphiphiles reinforced Pickering emulsion for 3D printing.  CARBOHYDRATE POLYMERS,  299  (120170). 
6. Yinghua Jia, Jinmin Wang, Limin Zhao, Bing Yan.  (2022)  A double responsive fluorescent platform for sensing heavy metal ions based on a dual-emitting fluorescent covalent organic framework hydrogel film.  DALTON TRANSACTIONS,  51  (37): (14352-14358). 
7. Yuhan Wang, Xiaonan Zheng, Weiting Zhong, Zihan Ye, Xinzhi Wang, Ziyue Dong, Zhenkun Zhang.  (2022)  Multicomponent chiral hydrogel fibers with block configurations based on the chiral liquid crystals of cellulose nanocrystals and M13 bacteriophages.  Polymer Chemistry,  13  (36): (5200-5211). 
8. Jie Zhang, Xibin Zhou, Jun Wang, Dawei Fang.  (2022)  A red-emitting Europium(III) complex as a luminescent probe with large Stokes shift for the sequential determination of Cu2+ and biothiols in real samples.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  282  (121663). 
9. Youqiang Fang, Zheng Liu, Haixia Wang, Xing Luo, Yanteng Xu, Hon Fai Chan, Shixian Lv, Yu Tao, Mingqiang Li.  (2022)  Implantable Sandwich-like Scaffold/Fiber Composite Spatiotemporally Releasing Combretastatin A4 and Doxorubicin for Efficient Inhibition of Postoperative Tumor Recurrence.  ACS Applied Materials & Interfaces,  14  (24): (27525–27537). 
10. Ting Liu, Jianwei Huang, He Ding, Chengsen Zhan, Shouyu Wang.  (2022)  Molecular structure perspective on Temperature-Sensitive properties of rhodamine aqueous solutions.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  275  (121166). 
11. Shunyu Huang, Jingji Li, Jipeng Wang.  (2021)  Clay Minerals Change the Toxic Effect of Cadmium on the Activities of Leucine Aminopeptidase.  ADSORPTION SCIENCE & TECHNOLOGY,  2021  (1024085). 
12. Xiaozheng Sun, Yanhua Xue, Jianye Li, Yu Yang, Yu Bai, Yujia Chen.  (2021)  Fluorescent labeling and characterization of dicarboxylic cellulose nanocrystals prepared by sequential periodate–chlorite oxidation.  RSC Advances,  11  (40): (24694-24701). 
13. Ji Chen, Guotao Li, Qihong Liu, Yan Liang, Miaochang Liu, Huayue Wu, Wenxia Gao.  (2019)  A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro.  Nanomaterials,  (6): (860). 
14. Wei Yanke, Mei Lefu, Li Rui, Liu Meng, Lv Guocheng, Weng Jianle, Liao Libing, Li Zhaohui, Lu Lin.  (2018)  Fabrication of an AMC/MMT Fluorescence Composite for its Detection of Cr(VI) in Water.  Frontiers in Chemistry,   
15. Qianqian Wu, Zhiqiang Liu, Duxia Cao, Ruifang Guan, Kangnan Wang, Yanyan Shan, Yongxiao Xu, Lin Ma.  (2015)  Coumarin amide derivatives as fluorescence chemosensors for cyanide anions.  MATERIALS CHEMISTRY AND PHYSICS,  161  (43). 
16. Jingjing Deng, Ping Yu, Yuexiang Wang, Lanqun Mao.  (2015)  Real-time Ratiometric Fluorescent Assay for Alkaline Phosphatase Activity with Stimulus Responsive Infinite Coordination Polymer Nanoparticles.  ANALYTICAL CHEMISTRY,  87  (5): (3080–3086). 
17. Jiadi Sun, Ye Zhu, Long Meng, Wei Wei, Yang Li, Xiaoya Liu, Yufeng Zheng.  (2015)  Controlled release and corrosion protection by self-assembled colloidal particles electrodeposited onto magnesium alloys.  Journal of Materials Chemistry B,  (8): (1667-1676). 
18. Jiadi Sun, Xiaoya Liu, Long Meng, Wei Wei, Yufeng Zheng.  (2014)  One-Step Electrodeposition of Self-Assembled Colloidal Particles: A Novel Strategy for Biomedical Coating.  LANGMUIR,  30  (37): (11002–11010). 
19. Zhang Rongli, Xu Sheng, Luo Jing, Liu Xiaoya.  (2015)  Molecularly imprinted photo-sensitive polyglutamic acid nanoparticles for electrochemical sensing of hemoglobin.  MICROCHIMICA ACTA,  182  (1): (175-183). 
20. Zhang Rong-li, Sun Jia-di, Luo Jing, Xu Sheng, Liu Xiao-ya.  (2014)  Preparation of photo-sensitive poly(γ-glutamic acid) nanoparticles and application for immobilizing hemoglobin on electrode.  COLLOID AND POLYMER SCIENCE,  292  (9): (2295-2302). 
21. Hui Yang, Peng Fei Gao, Wen Bi Wu, Xiao Xi Yang, Qiao Ling Zeng, Chong Li, Cheng Zhi Huang.  (2014)  Antibacterials loaded electrospun composite nanofibers: release profile and sustained antibacterial efficacy.  Polymer Chemistry,  (6): (1965-1975). 
22. Zengchen Liu,Bo Li,Baodui Wang,Zhengyin Yang,Qin Wang,Tianrong Li,Dongdong Qin,Yong Li,Mingfang Wang,Mihui Yan.  (2012-06-16)  Magnetic nanoparticles modified with DTPA-AMC-rare earth for fluorescent and magnetic resonance dual mode imaging..  Dalton transactions (Cambridge, England : 2003),  41  ((28)): (8723-8728). 
23. Yi-jing Yin, Xing-wang Wang, Wei-qi Lu, Zhao-yang Chen, Jia-yin Fu, Ke-feng Ren, Jian Ji.  (2025)  Adhesive polyelectrolyte coating on PLGA particles prolongs drug retention to vessel lesion.  JOURNAL OF CONTROLLED RELEASE,  378  (949). 
24. Zhang Jie, Yin Yi-jing, Wang Xing-wang, Lu Wei-qi, Chen Zhao-yang, Yu Chao-hui, Ren Ke-feng, Xu Cheng-fu.  (2025)  Adhesive polyelectrolyte coating through UV-triggered polymerization on PLGA particles for enhanced drug delivery to inflammatory intestinal mucosa.  JOURNAL OF NANOBIOTECHNOLOGY,  23  (1): (1-16). 
25. Tianyuan Xu, Lu Fan, Li Wang, Haozhen Ren, Qingfei Zhang, Weijian Sun.  (2024)  Hierarchical mesoporous silicon and albumin composite microparticles delivering DOX and FU for liver cancer treatment.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  268  (131732). 
26. Haoyu Qiu, Lisha Gong, Paul Slezak, Shixiong He, Fei Lu, Kun Yu, Jing Xie, Zhen Geng, Enling Hu, Zhihang Zhou, Guangqian Lan, Ruiqi Xie.  (2024)  Magnetic-navigable silk fibroin microneedles for oral drug delivery: Ensuring long-lasting helicobacter pylori eradication and rapid hemostasis in the stomach.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  275  (133584). 
27. Zhouyi Xiong, Mingqian Zhou, Shan Xiao, Zhongli Zhang, Dan Li.  (2024)  Refrigerated Storage-Induced Quality Deterioration of Mandarin Fish (Siniperca chuatsi): Analyzing the Role of Endogenous Enzymes through TMT-Based Quantitative Proteomics.  LWT-FOOD SCIENCE AND TECHNOLOGY,    (116721). 
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29. Kan Chen, Rui Yang, Min Li, Yanan Chen, Xiurong Han, Jing Zhao, Keqiang Li, Xiulin Wang.  (2024)  The Hydrophobic Component of Terrestrial Dissolved Organic Nitrogen Promotes Shifting Diatom–Dinoflagellate Dominance in the Bohai Sea.  JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS,  129  (10): (e2024JC021373). 

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