This is a demo store. No orders will be fulfilled.

 
Call +1 (833) 552-7181 or Contact us
Toggle Nav
My Cart
Search
Advanced Search
Menu
Account
Settings
྾
main product photo

6-Hydroxydopamine hydrobromide - 95%, high purity , CAS No.636-00-0

4 Citations COA COA
    Grade & Purity:
  • ≥95%
In stock
Item Number
H197233
Grouped product items
SKU Size
Availability
 Price Qty
H197233-10mg
10mg
3
$32.90
H197233-50mg
50mg
3
$134.90
H197233-250mg
250mg
3
$607.90
H197233-1g
1g
1
$764.90
H197233-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$3,442.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Selective catecholaminergic neurotoxin.

View related series
Apoptosis (4276) Autophagy (1917) Caspase (131) Class A GPCR (4138) COX (258) Dopamine Receptor (237) GPCR/G Protein (3172) Immunology/Inflammation (1929) Interleukin Related (129) Intrinsic Pathway (690) MAPK/ERK Pathway (546) Neuronal Signaling (3320) p38 MAPK (136) PGE synthase (25)

Basic Description

Synonyms 2,5-Dihydroxytyramine hydrobromide | HY-B1081A | SY102034 | 6-OHDA hydrobromide6-Hydroxydopamine hydrobromide | 5-(2-aminoethyl)benzene-1,2,4-triol;hydrobromide | BCP25700 | NSC238469 | NSC-238469 | TWC1D4W0WB | EINECS 217-598-6 | 636-00-0 (HBr) | Q272904
Specifications & Purity ≥95%
Biochemical and Physiological Mechanisms Neurotoxin that destroys catecholaminergic terminals.Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels. Induces apoptosis in PC-12 cells.\xa0Destroys\xa0nigral dopaminergic neurons and their striatal terminals\xa0in rat models of
Storage Temp Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Solutions should be freshly prepared and protected from exposure to light.
6-Hydroxydopamine hydrobromide is a neurotoxin which destroys catecholaminergic terminals.


product description：

6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson's disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Phenols
Subclass Benzenediols
Intermediate Tree Nodes Catechols
Direct Parent Catecholamines and derivatives
Alternative Parents Phenethylamines  Hydroxyquinols and derivatives  2-arylethylamines  Aralkylamines  1-hydroxy-2-unsubstituted benzenoids  Polyols  Organopnictogen compounds  Monoalkylamines  Hydrocarbon derivatives  Hydrobromides  
Molecular Framework Aromatic homomonocyclic compounds
Substituents Catecholamine - Hydroxyquinol derivative - Phenethylamine - 2-arylethylamine - 1-hydroxy-2-unsubstituted benzenoid - Aralkylamine - Monocyclic benzene moiety - Polyol - Primary amine - Amine - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrobromide - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as catecholamines and derivatives. These are compounds containing 4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] or a derivative thereof formed by substitution.
External Descriptors Not available

Associated Targets(Human)

VDR Tclin Vitamin D receptor (26531 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FEN1 Tchem Flap endonuclease 1 (12055 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLH Tchem DNA polymerase eta (21678 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
G6PD Tchem Glucose-6-phosphate 1-dehydrogenase (778 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ERG Tbio Transcriptional regulator ERG (5589 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EYA2 Tbio Eyes absent homolog 2 (5884 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (15528 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
WRN Tbio Werner syndrome ATP-dependent helicase (8824 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
G6PD-6PGL Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (1761 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 5-(2-aminoethyl)benzene-1,2,4-triol;hydrobromide
INCHI InChI=1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
InChIKey MLACDGUOKDOLGC-UHFFFAOYSA-N
Smiles C1=C(C(=CC(=C1O)O)O)CCN.Br
Isomeric SMILES C1=C(C(=CC(=C1O)O)O)CCN.Br
WGK Germany 3
RTECS DC4600000
Molecular Weight 250.09
Beilstein 3713280
Reaxy-Rn 3713280
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3713280&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

13 results found

Lot Number Certificate Type Date Item
I2104257 Certificate of Analysis Jun 09, 2025 H197233
B2311696 Certificate of Analysis Sep 02, 2022 H197233
G2504060 Certificate of Analysis Sep 02, 2022 H197233
B2311695 Certificate of Analysis Sep 02, 2022 H197233
B2311660 Certificate of Analysis Sep 02, 2022 H197233
B2311699 Certificate of Analysis Sep 02, 2022 H197233
B2311698 Certificate of Analysis Sep 02, 2022 H197233
A2510121 Certificate of Analysis Sep 02, 2022 H197233
B2211106 Certificate of Analysis Dec 20, 2021 H197233
B2211337 Certificate of Analysis Dec 20, 2021 H197233
B2211277 Certificate of Analysis Dec 20, 2021 H197233
B2211201 Certificate of Analysis Dec 20, 2021 H197233
B2211133 Certificate of Analysis Dec 20, 2021 H197233

Show more⌵

Chemical and Physical Properties

Solubility Soluble in DMSO, highest concentration (mg/mL): 50, highest concentration (mM): 199.93; soluble in H2O, highest concentration (mg/mL): 50, highest concentration (mM): 199.93; soluble in Ethanol, highest concentration (mg/mL): 50, the highest concentration
Sensitivity Light&Moisture sensitive
Melt Point(°C) 216-220°C
Molecular Weight 250.090 g/mol
XLogP3
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 2
Exact Mass 249 Da
Monoisotopic Mass 249 Da
Topological Polar Surface Area 86.700 Ų
Heavy Atom Count 13
Formal Charge 0
Complexity 142.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Xue-Yun Chen, Si-Ning Feng, Yin Bao, Yu-Xin Zhou, Fang Ba.  (2023)  Identification of Clec7a as the therapeutic target of rTMS in alleviating Parkinson's disease: targeting neuroinflammation.  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,  1869  (166814). 
2. Yi-Kao Hu, Yi-Ming Liu, Xiao-Lin Bai, Chao Ma, Xun Liao.  (2023)  Screening of Monoamine Oxidase B Inhibitors from Fragaria nubicola by Ligand Fishing and Their Neuroprotective Effects.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  71  (1): (512–521). 
3. Feifei Zhu, Han Chen, Jinying Han, Weiwei Zhou, Qi Tang, Qian Yu, Shangshang Ma, Xiaoyong Liu, Shuhao Huo, Keping Chen.  (2022)  Proteomic and Targeted Metabolomic Studies on a Silkworm Model of Parkinson’s Disease.  JOURNAL OF PROTEOME RESEARCH,  21  (9): (2114–2123). 
4. Baoxiang Wang, Lihua Geng, Jing Wang, Yuxi Wei, Changhui Yan, Ning Wu, Yang Yue, Quanbin Zhang.  (2024)  Optimization of the Preparation Process of Glucuronomannan Oligosaccharides and Their Effects on the Gut Microbiota in MPTP-Induced PD Model Mice.  Marine Drugs,  22  (5): (193). 

Solution Calculators

Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.

Privacy Policy Website Terms of Use Return policy Terms and Conditions of Sale Cookie Policy Sales Policy
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Copyright © 2023-present Aladdin Scientific Corp . All rights reserved.