This is a demo store. No orders will be fulfilled.

5-(Piperazin-1-ylsulfonyl)isoquinoline - ≥98%, high purity , CAS No.84468-24-6

    Grade & Purity:
  • ≥98%
In stock
Item Number
H275141
Grouped product items
SKU Size
Availability
Price Qty
H275141-10mg
10mg
3
$117.90
H275141-50mg
50mg
3
$474.90
H275141-100mg
100mg
2
$890.90

Myosin light chain kinase, PKA, PKC and PKG inhibitor

Basic Description

Synonyms 1-(5-Isoquinolinesulfonyl)piperazine | Piperazine, 1-(5-isoquinolinylsulfonyl)- | BDBM15203 | MFCD00209852 | NCGC00024641-01 | HA 100 | D80372 | SCHEMBL1272907 | AKOS009604745 | 1-(5-Isoquinolinylsulfonyl)piperazine | 1-(5-Isoquinolinylsulfonyl)-piperazin
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Myosin light chain kinase, PKA, PKC and PKG inhibitor (IC 50 values are 8 (PKA), 12 (PKC), 4 (PKG) and 240 μM (myosin light chain kinase)).
Storage Temp Store at 2-8°C,Argon charged,Desiccated
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Isoquinolines and derivatives
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Isoquinolines and derivatives
Alternative Parents Pyridines and derivatives  Piperazines  Organosulfonamides  Benzenoids  Sulfonyls  Heteroaromatic compounds  Dialkylamines  Azacyclic compounds  Organopnictogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Isoquinoline - 1,4-diazinane - Piperazine - Pyridine - Organosulfonic acid amide - Benzenoid - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - Heteroaromatic compound - Secondary amine - Secondary aliphatic amine - Azacycle - Amine - Organic oxide - Organopnictogen compound - Organosulfur compound - Organonitrogen compound - Organic oxygen compound - Hydrocarbon derivative - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as isoquinolines and derivatives. These are aromatic polycyclic compounds containing an isoquinoline moiety, which consists of a benzene ring fused to a pyridine ring and forming benzo[c]pyridine.
External Descriptors Not available

Associated Targets(Human)

ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PRKD3 Tchem Protein kinase C (PKC) (1010 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PRKACB Tchem cAMP-dependent protein kinase (PKA) (929 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pfmrk Protein kinase Pfmrk (149 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504750684
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504750684
IUPAC Name 5-piperazin-1-ylsulfonylisoquinoline
INCHI InChI=1S/C13H15N3O2S/c17-19(18,16-8-6-14-7-9-16)13-3-1-2-11-10-15-5-4-12(11)13/h1-5,10,14H,6-9H2
InChIKey UPTYCYWTFGTCCG-UHFFFAOYSA-N
Smiles C1CN(CCN1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
Isomeric SMILES C1CN(CCN1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
Molecular Weight 277.34
Reaxy-Rn 4263708
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4263708&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
A2207873 Certificate of Analysis Oct 21, 2022 H275141
A2207867 Certificate of Analysis Oct 21, 2022 H275141
A2207872 Certificate of Analysis Oct 21, 2022 H275141

Chemical and Physical Properties

Solubility Soluble in water to 100 mM and in DMSO to 25 mM
Molecular Weight 277.340 g/mol
XLogP3 0.600
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 2
Exact Mass 277.088 Da
Monoisotopic Mass 277.088 Da
Topological Polar Surface Area 70.700 Ų
Heavy Atom Count 19
Formal Charge 0
Complexity 401.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.