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5′-Deoxyadenosine - ≥98%, high purity , CAS No.4754-39-6

COA

Grade & Purity:

≥98%

Cas Number: 4754-39-6
Molecular Weight: 251.24
PubChem CID: 439182

In stock

Item Number

D350076

Grouped product items
SKU	Size	Availability	Price
D350076-5mg	5mg	3	$45.90
D350076-10mg	10mg	3	$77.90
D350076-25mg	25mg	2	$157.90
D350076-50mg	50mg	1	$251.90
D350076-100mg	100mg	1	$377.90

an analog of adenosin, and an intermediate in the degradation reaction of S-adenosylmethionine.

View related series

Anti-infection (2803) Metabolite (5307) Nucleosides and nucleotides (23) Orthopoxvirus (59) Virus (1811)

Basic Description

Synonyms	5′-dAdo
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	5 '- deoxyadenosine is a substrate of methylthioadenosine/S-adenosine homocysteine (MTA/SAH) nucleosidase in microorganisms. 5 '- deoxyadenosine is a byproduct of S-adenosylmethionine (SAM) cleavage. High levels of deoxyadenosine inhibit SAM dependent enz
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	5′-Deoxyadenosine is an analog of adenosin. In the degradation reaction of S-adenosylmethionine (SAM), 5′-Deoxyadenosine is an intermediate. 5′-Deoxyadenosine is used to study the enzyme kinematics of phosphomethylpyrimidine synthase, glutamate mutase, and 5′-methylthioadenosine phosphorylase. In addition, 5′-Deoxyadenosine has been used as a mass spectroscopy standard, and a thymidine phosphorylase activity screening inhibitor. Finally, 5′-Deoxyadenosine functions as a substrate if 5′-Deoxyadenosine deaminase (DadD) assay.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Nucleosides, nucleotides, and analogues
  - Class 5'-deoxyribonucleosides

Kingdom	Organic compounds
Superclass	Nucleosides, nucleotides, and analogues
Class	5'-deoxyribonucleosides
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	5'-deoxyribonucleosides
Alternative Parents	Glycosylamines 6-aminopurines Aminopyrimidines and derivatives N-substituted imidazoles Imidolactams Tetrahydrofurans Heteroaromatic compounds Secondary alcohols 1,2-diols Oxacyclic compounds Azacyclic compounds Primary amines Organopnictogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	5'-deoxyribonucleoside - Glycosyl compound - N-glycosyl compound - 6-aminopurine - Purine - Imidazopyrimidine - Aminopyrimidine - Imidolactam - Pyrimidine - N-substituted imidazole - Azole - Heteroaromatic compound - Imidazole - Tetrahydrofuran - 1,2-diol - Secondary alcohol - Oxacycle - Azacycle - Organoheterocyclic compound - Alcohol - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Amine - Primary amine - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as 5'-deoxyribonucleosides. These are nucleosides in which the oxygen atom at the 5'position of the ribose moiety has been replaced by another atom. The nucleobases here are limited to purine, pyrimidine, and pyridine derivatives.
External Descriptors	adenosines - 5'-deoxyribonucleoside
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

pKa	pKa: 13.29 (Predicted), pKa: 3.82 (Predicted)
Ki Data	Adenosine A1 receptor: Ki= 269 nM (rat); Adenosine A2a receptor: Ki= 596 nM (rat); Adenosine A3 receptor: Ki= 2.83 μM (rat)

Associated Targets(Human)

ADORA1 Tclin Adenosine A1 receptor (17603 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADORA2A Tclin Adenosine A2a receptor (16305 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADORA3 Tchem Adenosine A3 receptor (15931 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MTAP Tchem S-methyl-5-thioadenosine phosphorylase (233 Activities)

Discover Target: MTAP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HeLa (62764 Activities)

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Associated Targets(non-human)

Rattus norvegicus (775804 Activities)

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Vero (26788 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-methyloxolane-3,4-diol
INCHI	InChI=1S/C10H13N5O3/c1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15/h2-4,6-7,10,16-17H,1H3,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
InChIKey	XGYIMTFOTBMPFP-KQYNXXCUSA-N
Smiles	CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O
Isomeric SMILES	C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O
WGK Germany	3
RTECS	AU7358650
Molecular Weight	251.24
Reaxy-Rn	24731656
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24731656&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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10 results found

Lot Number	Certificate Type	Date	Item
G2410091	Certificate of Analysis	May 22, 2024	D350076
G2410118	Certificate of Analysis	May 22, 2024	D350076
G2410119	Certificate of Analysis	May 22, 2024	D350076
G2410120	Certificate of Analysis	May 22, 2024	D350076
G2410121	Certificate of Analysis	May 22, 2024	D350076
G2410288	Certificate of Analysis	May 22, 2024	D350076
G2410369	Certificate of Analysis	May 22, 2024	D350076
G2410370	Certificate of Analysis	May 22, 2024	D350076
G2410371	Certificate of Analysis	May 22, 2024	D350076
G2410372	Certificate of Analysis	May 22, 2024	D350076

Chemical and Physical Properties

Solubility	Soluble in water (19.60 - 20.40 m mg/ml).
Refractive Index	n20D1.87 (Predicted)
Boil Point(°C)	595.0° C at 760 mmHg (Predicted)
Melt Point(°C)	203-205° C
Molecular Weight	251.240 g/mol
XLogP3	-0.600
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	1
Exact Mass	251.102 Da
Monoisotopic Mass	251.102 Da
Topological Polar Surface Area	119.000 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	320.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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5′-Deoxyadenosine - ≥98%, high purity , CAS No.4754-39-6

Basic Description

Taxonomic Classification

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

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