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5-(4-Phenoxybutoxy)psoralen - 98%, high purity , CAS No.870653-45-5, Channel blocker of K v1.3

COA COA
In stock
Item Number
P120182
Grouped product items
SKU Size
Availability
 Price Qty
P120182-5mg
5mg
5
$103.90
P120182-25mg
25mg
3
$371.90
P120182-100mg
100mg
3
$1,084.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
Ion channel (2197) Kv1.3 Channel blocker (13) Membrane Transporter/Ion Channel (1822) Potassium Channel (253)

Basic Description

Synonyms PAP-1 | HY-10015 | AKOS015920200 | SPS-4251 | 5-(4-Phenoxybutoxy)psoralen;4-(4-Phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one | 4-(4-phenoxybutoxy)furo[3,2-g]chromen-7-one | CS-0299 | 4-[4-(phenoxy)butoxy]furo[3,2-g]chromen-7-one | AC-1703 | Cis-11-tetradecen
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms Selective inhibitor of Kv1.3, voltage-gated K+ channel. PAP-1 (EC50=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. Effective orally or intraperitoneally. 5-(4-Phenoxybutoxy)psoralen has 23-fold selectivity
Storage Temp Store at 2-8°C,Protected from light
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type CHANNEL BLOCKER
Mechanism of action Channel blocker of K v1.3
Product Description

PAP-1 is selective inhibitor of Kv1.3, voltage-gated K+ channel. PAP-1 (EC50=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. Effective orally or intraperitoneally. 5-(4-Phenoxybutoxy)psoralen has 23-fold selectivity for Kv1.3 over Kv1.5, and 33-125-fold selectivity over other Kv1 family channels. In treatment of multiple sclerosis

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Coumarins and derivatives
Subclass Furanocoumarins
Intermediate Tree Nodes Linear furanocoumarins
Direct Parent Psoralens
Alternative Parents 1-benzopyrans  Benzofurans  Phenoxy compounds  Phenol ethers  Pyranones and derivatives  Alkyl aryl ethers  Heteroaromatic compounds  Furans  Lactones  Oxacyclic compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Psoralen - Benzopyran - 1-benzopyran - Benzofuran - Phenoxy compound - Phenol ether - Alkyl aryl ether - Pyranone - Monocyclic benzene moiety - Benzenoid - Pyran - Heteroaromatic compound - Furan - Lactone - Oxacycle - Ether - Organoheterocyclic compound - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as psoralens. These are organic compounds containing a psoralen moiety, which consists of a furan fused to a chromenone to for 7H-furo[3,2-g]chromen-7-one.
External Descriptors Not available

Associated Targets(Human)

KCNA6 Tclin Potassium voltage-gated channel subfamily A member 6 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNA7 Tclin Potassium voltage-gated channel subfamily A member 7 (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNN4 Tchem Intermediate conductance calcium-activated potassium channel protein 4 (3 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNN1 Tchem Small conductance calcium-activated potassium channel protein 1 (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNN2 Tchem Small conductance calcium-activated potassium channel protein 2 (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNA3 Tclin Potassium voltage-gated channel subfamily A member 3 (8 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNA4 Tclin Potassium voltage-gated channel subfamily A member 4 (3 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNA2 Tclin Potassium voltage-gated channel subfamily A member 2 (3 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNA5 Tclin Potassium voltage-gated channel subfamily A member 5 (4 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNMA1 Tclin Calcium-activated potassium channel subunit alpha-1 (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNA1 Tclin Potassium voltage-gated channel subfamily A member 1 (3 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNH2 Tclin HERG (29587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNA5 Tclin Voltage-gated potassium channel subunit Kv1.5 (1353 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNN2 Tchem Small conductance calcium-activated potassium channel protein 2 (20 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNA2 Tclin Voltage-gated potassium channel subunit Kv1.2 (28 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNA3 Tclin Voltage-gated potassium channel subunit Kv1.3 (1067 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNN4 Tchem Intermediate conductance calcium-activated potassium channel protein 4 (87 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNMA1 Tclin Calcium-activated potassium channel subunit alpha-1 (435 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNN1 Tchem Small conductance calcium-activated potassium channel protein 1 (21 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNA7 Tclin Voltage-gated potassium channel subunit Kv1.7 (2 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNA1 Tclin Voltage-gated potassium channel subunit Kv1.1 (248 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U2OS (164939 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HaCaT (4069 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PBMC (10003 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNA6 Tclin Voltage-gated potassium channel subunit Kv1.6 (20 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNA4 Tclin Voltage-gated potassium channel subunit Kv1.4 (24 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK-293T (167025 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rhesus monkey (3147 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504766270
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504766270
IUPAC Name 4-(4-phenoxybutoxy)furo[3,2-g]chromen-7-one
INCHI InChI=1S/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2
InChIKey KINMYBBFQRSVLL-UHFFFAOYSA-N
Smiles C1=CC=C(C=C1)OCCCCOC2=C3C=CC(=O)OC3=CC4=C2C=CO4
Isomeric SMILES C1=CC=C(C=C1)OCCCCOC2=C3C=CC(=O)OC3=CC4=C2C=CO4
WGK Germany 3
Alternate CAS 870653-45-5
Molecular Weight 350.36
Reaxy-Rn 10371713
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10371713&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot Number Certificate Type Date Item
F23271289 Certificate of Analysis Dec 05, 2022 P120182
F23271300 Certificate of Analysis Dec 05, 2022 P120182
F23271296 Certificate of Analysis Dec 05, 2022 P120182
F23271291 Certificate of Analysis Dec 05, 2022 P120182
F23271295 Certificate of Analysis Dec 05, 2022 P120182
F23271288 Certificate of Analysis Dec 05, 2022 P120182
C2212131 Certificate of Analysis Jan 27, 2022 P120182
C2212144 Certificate of Analysis Jan 27, 2022 P120182
C2214225 Certificate of Analysis Jan 27, 2022 P120182

Chemical and Physical Properties

Solubility DMSO: 50 mg/mL (142.71 mM); Water: < 0.1 mg/mL (insoluble)
Sensitivity light sensitive
Molecular Weight 350.400 g/mol
XLogP3 4.700
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 7
Exact Mass 350.115 Da
Monoisotopic Mass 350.115 Da
Topological Polar Surface Area 57.900 Ų
Heavy Atom Count 26
Formal Charge 0
Complexity 499.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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