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4-Chloro-1-naphthol - 99%, high purity , CAS No.604-44-4

    Grade & Purity:
  • ≥99%
In stock
Item Number
C109038
Grouped product items
SKU Size
Availability
Price Qty
C109038-1g
1g
5
$24.90
C109038-5g
5g
5
$63.90
C109038-25g
25g
5
$286.90

Chromogenic peroxidase substrate.

Basic Description

Synonyms 4C1N 4-CN | 4-Chloro-1-naphthol, >=95.0% (HPLC), tablet (~32 mg each) | 4-Chloro-1-naphthol, for analytical purposes, >=99.0% | 4-chloronaphthol | Z104477546 | LVSPDZAGCBEQAV-UHFFFAOYSA- | C2291 | STR01788 | 1-chloro-4-naphthol | C-5180 | SY045975 | 1-Chl
Specifications & Purity ≥99%
Biochemical and Physiological Mechanisms Chromogenic peroxidase substrate that results in a precipitate that is blue to blue-purple in color and can be observed visually. Used for both western blotting and immunohistochemical staining. Can be used as a substitute in the myeloperoxidase stain for
Storage Temp Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

4-Chloro-1-naphthol is primarily used for the detection of proteins, it gives a characteristic purple precipitate and the reactions are easily controllable. It can be used as a substitute for benzidine compounds, which are considered to be carcinogenic.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Naphthalenes
Subclass Naphthols and derivatives
Intermediate Tree Nodes Not available
Direct Parent Naphthols and derivatives
Alternative Parents Chloronaphthalenes  1-hydroxy-2-unsubstituted benzenoids  Aryl chlorides  Organooxygen compounds  Organochlorides  Hydrocarbon derivatives  
Molecular Framework Aromatic homopolycyclic compounds
Substituents Chloronaphthalene - 1-naphthol - 1-hydroxy-2-unsubstituted benzenoid - Aryl halide - Aryl chloride - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Organochloride - Organohalogen compound - Aromatic homopolycyclic compound
Description This compound belongs to the class of organic compounds known as naphthols and derivatives. These are naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position.
External Descriptors Not available

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488181433
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488181433
IUPAC Name 4-chloronaphthalen-1-ol
INCHI InChI=1S/C10H7ClO/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6,12H
InChIKey LVSPDZAGCBEQAV-UHFFFAOYSA-N
Smiles C1=CC=C2C(=C1)C(=CC=C2Cl)O
Isomeric SMILES C1=CC=C2C(=C1)C(=CC=C2Cl)O
WGK Germany 3
Molecular Weight 178.61
Beilstein 509750
Reaxy-Rn 509750
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=509750&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number Certificate Type Date Item
C2507143 Certificate of Analysis Mar 12, 2025 C109038
C2316653 Certificate of Analysis Mar 20, 2023 C109038
C2316658 Certificate of Analysis Mar 20, 2023 C109038
C2316659 Certificate of Analysis Mar 20, 2023 C109038
C2316655 Certificate of Analysis Mar 20, 2023 C109038
C2316656 Certificate of Analysis Mar 20, 2023 C109038
C2316657 Certificate of Analysis Mar 20, 2023 C109038

Chemical and Physical Properties

Solubility Soluble in Methanol
Sensitivity Air & Light Sensitive
Melt Point(°C) 117-120°C
Molecular Weight 178.610 g/mol
XLogP3 3.900
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 1
Rotatable Bond Count 0
Exact Mass 178.019 Da
Monoisotopic Mass 178.019 Da
Topological Polar Surface Area 20.200 Ų
Heavy Atom Count 12
Formal Charge 0
Complexity 160.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

1. Xiaoran Tan, Jiaxin Liang, Haihan Yu, Yuanyuan Chen, Li Shan, Shenguang Ge, Lina Zhang, Li Li, Jinghua Yu.  (2023)  Magnetic field enabled spin-state reconfiguration for highly sensitive paper-based photoelectrochemical bioanalysis.  CHEMICAL ENGINEERING JOURNAL,  471  (144626). 
2. Jia Ding, Fei Liu, Chunling Qi, Yunlei Zhou, Huanshun Yin, Shiyun Ai.  (2021)  Enhanced photoactivity of perovskite Bi4NbO8Cl/PTC-NH2 heterojunction and its application for photoelectrochemical sensing of DNA hydroxymethylation.  SENSORS AND ACTUATORS B-CHEMICAL,  344  (130211). 
3. Saibo Chen, Hao Nan, Xuan Zhang, Yuting Yan, Zhou Zhou, Ying Zhang, Kun Wang.  (2017)  One-step hydrothermal treatment to fabricate Bi2WO6-reduced graphene oxide nanocomposites for enhanced visible light photoelectrochemical performance.  Journal of Materials Chemistry B,  (20): (3718-3727). 
4. Zhou, et al..  (2021)  Hydrolase CehA and a Novel Two-Component 1-Naphthol Hydroxylase CehC1C2 are Responsible for the Two Initial Steps of Carbaryl Degradation in Rhizobium sp. X9..  Journal of Agricultural and Food Chemistry,  68  (14739-14747). 
5. Su Yuan, Zhang Ziyu, Zhang Hongfang.  (2025)  A dual-mode biosensor for microRNA detection based on DNA tetrahedron-gated nanochannels.  MICROCHIMICA ACTA,  192  (2): (1-9). 
6. Xianchen Hu, Yali Xu, Yuexi Lin, Xinghe Chen, Junshan Lin.  (2025)  Tyramine–enzyme conjugate repeats for an interdigitated capacitance immunosensing array in the detection of neuroblastoma biomarker neuron-specific enolase.  ANALYST,  150  (5): (914-921). 

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