Determine the necessary mass, volume, or concentration for preparing a solution.
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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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A105007-25g
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25g |
4
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$37.90
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A105007-100g
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100g |
5
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$133.90
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A105007-250g
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250g |
1
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$300.90
|
|
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A105007-500g
|
500g |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
|
$540.90
|
|
Competitive pteridine synthetase inhibitor
| Synonyms | 2-Hydroxy-4-aminobenzoic acid | 4-Asa | Osacyl | PAS-C | WLN: ZR CQ DVQ | Benzoic acid, 4-aminohydroxy- | Granupas | KBioSS_000422 | BRN 0473071 | Pamisyl (TN) | Apacil | Spectrum_000042 | 4-14-00-01967 (Beilstein Handbook Reference) | MLS000069418 | p-am |
|---|---|
| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | Competitive pteridine synthetase inhibitor. Shows antituberculosis activity. Inhibits NF-κB and folic acid synthesis. Orally active. |
| Storage Temp | Argon charged |
| Shipped In | Normal |
| Action Type | INHIBITOR |
| Mechanism of action | Dihydrofolate reductase inhibitor |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description |
4-Aminosalicylic acid is an inhibitor of NF κ B. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Benzene and substituted derivatives |
| Subclass | Benzoic acids and derivatives |
| Intermediate Tree Nodes | Hydroxybenzoic acid derivatives - Salicylic acid and derivatives - Aminosalicylic acids and derivatives |
| Direct Parent | Aminosalicylic acids |
| Alternative Parents | 4-aminosalicylic acids Salicylic acids Aminobenzoic acids Benzoic acids m-Aminophenols Benzoyl derivatives Aniline and substituted anilines 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Vinylogous acids Amino acids Monocarboxylic acids and derivatives Carboxylic acids Hydrocarbon derivatives Organic oxides Organooxygen compounds Organopnictogen compounds Primary amines |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | 4-aminosalicylic acid - Aminosalicylic acid - Salicylic acid - Aminobenzoic acid or derivatives - Aminobenzoic acid - Benzoic acid - Aniline or substituted anilines - M-aminophenol - Aminophenol - Benzoyl - 1-hydroxy-2-unsubstituted benzenoid - 1-hydroxy-4-unsubstituted benzenoid - Phenol - Vinylogous acid - Amino acid - Amino acid or derivatives - Carboxylic acid derivative - Monocarboxylic acid or derivatives - Carboxylic acid - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Primary amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Amine - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as aminosalicylic acids. These are salicylic acids carrying an amino group on the benzene ring. |
| External Descriptors | phenols - aminobenzoic acid |
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| ALogP | 1.3 |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Pubchem Sid | 488179842 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179842 |
| IUPAC Name | 4-amino-2-hydroxybenzoic acid |
| INCHI | InChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11) |
| InChIKey | WUBBRNOQWQTFEX-UHFFFAOYSA-N |
| Smiles | C1=CC(=C(C=C1N)O)C(=O)O |
| Isomeric SMILES | C1=CC(=C(C=C1N)O)C(=O)O |
| WGK Germany | 2 |
| RTECS | VO1225000 |
| Molecular Weight | 153.14 |
| Beilstein | 473071 |
| Reaxy-Rn | 473071 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=473071&ln= |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jan 15, 2025 | A105007 | |
| Certificate of Analysis | Oct 18, 2024 | A105007 | |
| Certificate of Analysis | Aug 22, 2024 | A105007 | |
| Certificate of Analysis | Jul 08, 2024 | A105007 | |
| Certificate of Analysis | Jul 08, 2024 | A105007 | |
| Certificate of Analysis | Jan 22, 2024 | A105007 | |
| Certificate of Analysis | Dec 21, 2023 | A105007 | |
| Certificate of Analysis | Jul 13, 2023 | A105007 | |
| Certificate of Analysis | Jul 13, 2023 | A105007 | |
| Certificate of Analysis | Jul 13, 2023 | A105007 | |
| Certificate of Analysis | Jul 13, 2023 | A105007 | |
| Certificate of Analysis | Jul 13, 2023 | A105007 | |
| Certificate of Analysis | Jul 13, 2023 | A105007 | |
| Certificate of Analysis | Jun 07, 2023 | A105007 | |
| Certificate of Analysis | Sep 05, 2022 | A105007 | |
| Certificate of Analysis | Jun 09, 2022 | A105007 | |
| Certificate of Analysis | Jun 09, 2022 | A105007 | |
| Certificate of Analysis | Jun 09, 2022 | A105007 |
| Solubility | Soluble in water (2 g/l) at 20 °C, dilute sodium hydroxide, dilute nitric acid, ether (slightly), methanol, acetone, and ethanol (1 G SOL IN 21 ML ALC). Virtually insoluble in benzene, chloroform, and carbon tetrachloride |
|---|---|
| Sensitivity | Light and Air sensitive |
| Melt Point(°C) | 150-151°C |
| Molecular Weight | 153.140 g/mol |
| XLogP3 | 1.300 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 1 |
| Exact Mass | 153.043 Da |
| Monoisotopic Mass | 153.043 Da |
| Topological Polar Surface Area | 83.600 Ų |
| Heavy Atom Count | 11 |
| Formal Charge | 0 |
| Complexity | 160.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
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