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4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)quinolin-2(1H)-one , Calcium-activated potassium channel subunit alpha-1 activator, CAS No.275375-69-4, Calcium-activated potassium channel subunit alpha-1 activator
Basic Description
Synonyms
BMS-223131 | (-)-4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)quinolin-2(1H)-one | 2(1H)-Quinolinone, 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)- | 889F719S7K | QESHSZWKJULSAR-UHFFFAOYSA-N | 4-(5-chloro-2-hyd
Action Type
ACTIVATOR
Mechanism of action
Calcium-activated potassium channel subunit alpha-1 activator
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Organoheterocyclic compounds
Class
Quinolines and derivatives
Subclass
Phenylquinolines
Intermediate Tree Nodes
Not available
Direct Parent
Phenylquinolines
Alternative Parents
Phenylpyridines Hydroquinolones Hydroquinolines P-chlorophenols Pyridinones 1-hydroxy-2-unsubstituted benzenoids Chlorobenzenes Aryl chlorides Heteroaromatic compounds Lactams Azacyclic compounds Organic oxides Hydrocarbon derivatives Organochlorides Organofluorides Organonitrogen compounds Alkyl fluorides Primary alcohols
Molecular Framework
Aromatic heteropolycyclic compounds
Substituents
Phenylquinoline - 4-phenylpyridine - Dihydroquinolone - Dihydroquinoline - 4-halophenol - 4-chlorophenol - Chlorobenzene - Halobenzene - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Pyridinone - Benzenoid - Aryl chloride - Pyridine - Aryl halide - Monocyclic benzene moiety - Heteroaromatic compound - Lactam - Azacycle - Hydrocarbon derivative - Organohalogen compound - Organochloride - Organic oxygen compound - Alkyl halide - Organic nitrogen compound - Alkyl fluoride - Alcohol - Organofluoride - Organonitrogen compound - Primary alcohol - Organooxygen compound - Organic oxide - Aromatic heteropolycyclic compound
Description
This compound belongs to the class of organic compounds known as phenylquinolines. These are heterocyclic compounds containing a quinoline moiety substituted with a phenyl group.
External Descriptors
Not available
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-1H-quinolin-2-one
INCHI
InChI=1S/C18H13ClF3NO3/c19-10-2-4-15(25)13(8-10)16-11(5-6-24)17(26)23-14-3-1-9(7-12(14)16)18(20,21)22/h1-4,7-8,24-25H,5-6H2,(H,23,26)
InChIKey
QESHSZWKJULSAR-UHFFFAOYSA-N
Smiles
C1=CC2=C(C=C1C(F)(F)F)C(=C(C(=O)N2)CCO)C3=C(C=CC(=C3)Cl)O
Isomeric SMILES
C1=CC2=C(C=C1C(F)(F)F)C(=C(C(=O)N2)CCO)C3=C(C=CC(=C3)Cl)O
Molecular Weight
383.7
Reaxy-Rn
9440784
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9440784&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
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