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3-Iodo-L-tyrosine - 10mM in Water, high purity , CAS No.70-78-0
Tyrosine hydroxylase inhibitor
Basic Description
Synonyms
3-Iodo-L-tyrosine | 70-78-0 | H-Tyr(3-I)-OH | 3-IODOTYROSINE | L-Tyrosine, 3-iodo- | Monoiodotyrosine | (S)-2-Amino-3-(4-hydroxy-3-iodophenyl)propanoic acid | 3-IODO-TYROSINE | IODOTYROSINE | 3-Monoiodo-L-tyrosine | (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid | 3-Iod
Specifications & Purity
10mM in Water
Biochemical and Physiological Mechanisms
3-iodotyrosine (3-IY) inhibits tyrosine hydroxylase that catalyzes levodopa (L-DOPA) formation from tyrosine. Iodotyrosine deiodinase enzyme deficiency leads to elevated levels of 3-IY in serum and urine in severe hypothyroidism and goiter. TH (tyrosine 3
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description
Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3′-tri-iodothyronine (T3) or 3,3′,5′-tri-iodothyronine (rT3)
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Subclass
Amino acids, peptides, and analogues
Intermediate Tree Nodes
Amino acids and derivatives - Alpha amino acids and derivatives
Direct Parent
Tyrosine and derivatives
Alternative Parents
Phenylalanine and derivatives Phenylpropanoic acids Amphetamines and derivatives L-alpha-amino acids O-iodophenols 1-hydroxy-2-unsubstituted benzenoids Aralkylamines Iodobenzenes Aryl iodides Amino acids Monocarboxylic acids and derivatives Carboxylic acids Hydrocarbon derivatives Carbonyl compounds Organopnictogen compounds Organic oxides Organoiodides Monoalkylamines
Molecular Framework
Aromatic homomonocyclic compounds
Substituents
Tyrosine or derivatives - Phenylalanine or derivatives - 3-phenylpropanoic-acid - Alpha-amino acid - Amphetamine or derivatives - L-alpha-amino acid - 2-iodophenol - 2-halophenol - 1-hydroxy-2-unsubstituted benzenoid - Iodobenzene - Halobenzene - Phenol - Aralkylamine - Aryl iodide - Aryl halide - Benzenoid - Monocyclic benzene moiety - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Organic nitrogen compound - Organohalogen compound - Primary aliphatic amine - Organoiodide - Organonitrogen compound - Organooxygen compound - Primary amine - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Amine - Aromatic homomonocyclic compound
Description
This compound belongs to the class of organic compounds known as tyrosine and derivatives. These are compounds containing tyrosine or a derivative thereof resulting from reaction of tyrosine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
External Descriptors
Other amino acids
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
(2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid
INCHI
InChI=1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
InChIKey
UQTZMGFTRHFAAM-ZETCQYMHSA-N
Smiles
C1=CC(=C(C=C1CC(C(=O)O)N)I)O
Isomeric SMILES
C1=CC(=C(C=C1C[C@@H](C(=O)O)N)I)O
WGK Germany
3
Molecular Weight
307.09
Beilstein
2941266
Reaxy-Rn
2215172
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2215172&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Sensitivity
Light sensitive; Air sensitive; Heat sensitive
Specific Rotation[α]
-3° (C=2,1mol/L Hcl)
Melt Point(°C)
210°C
Molecular Weight
307.080 g/mol
XLogP3
-1.100
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
3
Exact Mass
306.971 Da
Monoisotopic Mass
306.971 Da
Topological Polar Surface Area
83.600 Ų
Heavy Atom Count
14
Formal Charge
0
Complexity
212.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
1
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
Citations of This Product
1.
Qinhong Yin, Xiaolan Yang, Lihua Yang, Dezhi Yang, Yaling Yang, Yanqin Zhu.
(2023)
Cu, I-doped carbon dots as simulated nanozymes for the colorimetric detection of morphine in biological samples. ANALYTICAL BIOCHEMISTRY,
680
(115313).
2.
Xiao Li, Yan Xu, Dimei Ouyang, Kefan Ye, Yiwen Chen, Qiulan Li, Qinghai Xia, Xiaomei Wu, Yaling Yang.
(2023)
Copper- and iodine-doped nanozymes with simulated enzyme activity and efficient antifungal activity against Candida albicans. BIOCHEMICAL ENGINEERING JOURNAL,
191
(108791).
3.
Yang Dezhi, Li Qiulan, Zhang Qian, Wang Yijie, Li Hong, Tammina Sai Kumar, Yang Yaling.
(2022)
A multifunctional nanozyme-based enhanced system for tert-butyl hydroquinone assay by surface-enhanced Raman scattering. MICROCHIMICA ACTA,
189
(1):
(1-9).
4.
Yifan Cui, Dezhi Yang, Qiulan Li, Zhongmei Peng, Zitao Zhong, Yuzhu Song, Qinqin Han, Yaling Yang.
(2024)
Cu,Zn,I-Doped Carbon Dots with Boosted Triple Antioxidant Nanozyme Activity for Treatment of DSS-Induced Colitis. ACS Applied Materials & Interfaces,
16
(25):
(32619-32632).
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4 Citations