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3-AP - 98% (HPLC), high purity , CAS No.143621-35-6

6 Citations COA COA
    Grade & Purity:
  • ≥98%(HPLC)
In stock
Item Number
A167286
Grouped product items
SKU Size
Availability
 Price Qty
A167286-5mg
5mg
3
$64.90
A167286-10mg
10mg
3
$84.90
A167286-25mg
25mg
3
$188.90
A167286-100mg
100mg
2
$680.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Ribonucleotide reductase inhibitor; also an iron chelator

View related series
Cell Cycle (2830) Cell Cycle/DNA Damage (2602) DNA/RNA Synthesis (362) Nucleoside (18) nucleotide (15) oligonucleotide (7)

Basic Description

Synonyms [(E)-(3-amino-2-pyridyl)methyleneamino]thiourea | PAN-811;NSC# 663249;OCX191 | (e)-2-((3-aminopyridin-2-yl)methylene)hydrazine-1-carbothioamide | 5,6-dimethyl-2-aminobenzimidazole | SCHEMBL29370 | 3-AP | AS-16679 | NSC-663249 | Pan 811 | U4XIL4091C | DTXS
Specifications & Purity ≥98%(HPLC)
Biochemical and Physiological Mechanisms Ribonucleotide reductase inhibitor. Also an iron chelator. Inhibits leukemia cell growth and acts in synergy withcisplatin. Activein vivo. 3-aminopyridine carboxaldehyde thiosemicarbazone (3-AP) has a IC50 value of 0.3μM. It exhibits anti-proliferative a
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Pyridines and derivatives
Subclass Aminopyridines and derivatives
Intermediate Tree Nodes Not available
Direct Parent Aminopyridines and derivatives
Alternative Parents Thiosemicarbazones  Heteroaromatic compounds  Azacyclic compounds  Primary amines  Organosulfur compounds  Hydrocarbon derivatives  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Aminopyridine - Thiosemicarbazone - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Primary amine - Organosulfur compound - Organonitrogen compound - Amine - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as aminopyridines and derivatives. These are organic heterocyclic compounds containing an amino group attached to a pyridine ring.
External Descriptors Not available

Product Properties

ALogP -0.2

Associated Targets(Human)

RRM2 Tclin Ribonucleoside-diphosphate reductase subunit M2 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CISD1 Tchem CDGSH iron-sulfur domain-containing protein 1 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
RRM2 Tclin Ribonucleoside-diphosphate reductase M2 chain (14 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A498 (42825 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHN (49357 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BGC-823 (3035 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAKI-1 (44928 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CCRF-CEM (65223 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
COLO 205 (50209 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DU-145 (51482 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HL-60 (67320 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-29 (80576 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
K562 (73714 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KB 3-1 (1143 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KM12 (47707 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
M14 (47487 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MES-SA (905 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MES-SA/Dx5 (643 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MOLT-4 (49676 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MRC5 (9203 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-3 (48710 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-4 (44535 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-5 (45555 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-8 (47708 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-3 (62116 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RPMI-8226 (44974 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RXF 393 (41971 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SF-295 (48000 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SGC-7901 (2773 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-2 (46422 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-28 (48833 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-5 (47095 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-N-MC (815 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-OV-3 (52876 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SN12C (47755 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SNB-19 (46794 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SW480 (6023 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TK-10 (45540 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U-251 (51189 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UACC-257 (46019 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UACC-62 (47335 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UO-31 (46270 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
WI-38 (2654 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
786-0 (47912 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI/ADR-RES (33767 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
T47D (39041 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ECa-109 cell line (1254 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EKVX (44102 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H322M (45589 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCC 2998 (41480 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Canis familiaris (36305 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
L1210 (27553 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
M109 (194 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504764828
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504764828
IUPAC Name [(E)-(3-aminopyridin-2-yl)methylideneamino]thiourea
INCHI InChI=1S/C7H9N5S/c8-5-2-1-3-10-6(5)4-11-12-7(9)13/h1-4H,8H2,(H3,9,12,13)/b11-4+
InChIKey XMYKNCNAZKMVQN-NYYWCZLTSA-N
Smiles C1=CC(=C(N=C1)C=NNC(=S)N)N
Isomeric SMILES C1=CC(=C(N=C1)/C=N/NC(=S)N)N
WGK Germany 3
Molecular Weight 195.24
Reaxy-Rn 5811939
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5811939&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number Certificate Type Date Item
A2218214 Certificate of Analysis Nov 20, 2024 A167286
A2218104 Certificate of Analysis Nov 20, 2024 A167286
A2218092 Certificate of Analysis Nov 20, 2024 A167286
A2218209 Certificate of Analysis Nov 20, 2024 A167286

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 19.52, Max Conc. mM: 100
Sensitivity Heat Sensitive
Melt Point(°C) 234 °C
Molecular Weight 195.250 g/mol
XLogP3 -0.200
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 2
Exact Mass 195.058 Da
Monoisotopic Mass 195.058 Da
Topological Polar Surface Area 121.000 Ų
Heavy Atom Count 13
Formal Charge 0
Complexity 205.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 1
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 1
Covalently-Bonded Unit Count 1

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Xin-Xin Fu, Jian-Peng Li, Zhuo-Qian Li, Yan Liu, Chen-Xiao Feng, Hai-Yang Wang, Zhi-Peng Zhao, Qiao-Yun Liu, Zhong-Yi Liu, Zhi-Kun Peng.  (2022)  Selective conversion of 2-methylfuran to 3-acetyl-1-propanol in water over Pd@HZSM-5 catalyst with balanced metal-acid cooperation.  JOURNAL OF CATALYSIS,  413  (648). 
2. Li Zishuai, Cheng Simin, Lin Qiaohong, Cao Wenbo, Yang Jing, Zhang Minmin, Shen Aijun, Zhang Wenpeng, Xia Yu, Ma Xiaoxiao, Ouyang Zheng.  (2021)  Single-cell lipidomics with high structural specificity by mass spectrometry.  Nature Communications,  12  (1): (1-10). 
3. Sen Liu, Hao Ling, Juan Lv, Hongxia Gao, Yanqing Na, Zhiwu Liang.  (2019)  New Insights and Assessment of Primary Alkanolamine/Sulfolane Biphasic Solutions for Post-combustion CO2 Capture: Absorption, Desorption, Phase Separation, and Technological Process.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,  58  (44): (20461–20471). 
4. Jing Luo, Jiaojiao Cong, Jie Liu, Yahan Gao, Xiaoya Liu.  (2015)  A facile approach for synthesizing molecularly imprinted graphene for ultrasensitive and selective electrochemical detecting 4-nitrophenol.  ANALYTICA CHIMICA ACTA,  864  (74). 
5. Run Li, Xiandong Hao, Bo Wang, Ning Zhao, Zhiyong Xu, Wenbo Zhao.  (2024)  Highly efficient CO2 capture by a non-aqueous amine-based absorbent of 3 aminopropanol/polyethylene glycol 200: Experimental and computational simulation.  JOURNAL OF MOLECULAR LIQUIDS,  415  (126377). 
6. Di Wu, Yi Wang, Wenjing Qi, Jianyang Xu, Kanglin Pei, Lingyan Ma, Lin Qi.  (2024)  Long-lasting chemiluminescence of lucigenin/p-aminophenol system for detection of p-aminophenol in environmental water.  DYES AND PIGMENTS,  223  (111959). 

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