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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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T162132-100mg
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100mg |
2
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$36.90
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T162132-250mg
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250mg |
3
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$71.90
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T162132-500mg
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500mg |
2
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$123.90
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T162132-1g
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1g |
3
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$196.90
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T162132-5g
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5g |
1
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$679.90
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T162132-25g
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25g |
1
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$3,056.90
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|
| Synonyms | triiodothyronine | UNII-06LU7C9H1V | REGID_for_CID_5920 | Thyrolar-0.25 | Triiodothyronine, l- | 06LU7C9H1V | DTXSID8023216 | KBioSS_002577 | Triiodothyronine (T3) | 3,5,3'-Tri-iodo-L-thyronine | 3,5,3'-Triiodo-L-thyronine | BCBcMAP01_000192 | L-3-(4-(4-H |
|---|---|
| Specifications & Purity | Moligand™, ≥98%(HPLC) |
| Biochemical and Physiological Mechanisms | 3,3′,5-Triiodo-L-thyronine also referred to as O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine or T3 is the biologically active thyroid hormone. In hypothyroidism pateints, triiodothyronine enhances mood and neuropsychological function. The product also |
| Storage Temp | Store at -20°C |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Grade | Moligand™ |
| Action Type | AGONIST |
| Mechanism of action | Thyroid hormone receptor agonist |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Class | Carboxylic acids and derivatives |
| Subclass | Amino acids, peptides, and analogues |
| Intermediate Tree Nodes | Amino acids and derivatives - Alpha amino acids and derivatives |
| Direct Parent | Phenylalanine and derivatives |
| Alternative Parents | Diphenylethers Phenylpropanoic acids Diarylethers Amphetamines and derivatives L-alpha-amino acids Phenoxy compounds Phenol ethers O-iodophenols 1-hydroxy-2-unsubstituted benzenoids Aralkylamines Iodobenzenes Aryl iodides Amino acids Monocarboxylic acids and derivatives Carboxylic acids Carbonyl compounds Hydrocarbon derivatives Monoalkylamines Organic oxides Organoiodides Organopnictogen compounds |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Phenylalanine or derivatives - Diphenylether - Diaryl ether - 3-phenylpropanoic-acid - Alpha-amino acid - Amphetamine or derivatives - L-alpha-amino acid - Phenoxy compound - 2-iodophenol - 2-halophenol - Phenol ether - Iodobenzene - 1-hydroxy-2-unsubstituted benzenoid - Halobenzene - Phenol - Aralkylamine - Aryl iodide - Aryl halide - Monocyclic benzene moiety - Benzenoid - Amino acid - Ether - Carboxylic acid - Monocarboxylic acid or derivatives - Organic nitrogen compound - Primary aliphatic amine - Organohalogen compound - Organoiodide - Organonitrogen compound - Organooxygen compound - Primary amine - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Amine - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as phenylalanine and derivatives. These are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. |
| External Descriptors | thyroxine - Other amino acids |
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| ALogP | 1.7 |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| Pubchem Sid | 488179960 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179960 |
| IUPAC Name | (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid |
| INCHI | InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 |
| InChIKey | AUYYCJSJGJYCDS-LBPRGKRZSA-N |
| Smiles | C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)O)N)I)I)O |
| Isomeric SMILES | C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[C@@H](C(=O)O)N)I)I)O |
| RTECS | AY6750000 |
| PubChem CID | 5920 |
| Molecular Weight | 650.98 |
| Reaxy-Rn | 2710227 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jul 08, 2024 | T162132 | |
| Certificate of Analysis | Jul 08, 2024 | T162132 | |
| Certificate of Analysis | Jul 08, 2024 | T162132 | |
| Certificate of Analysis | Jul 08, 2024 | T162132 | |
| Certificate of Analysis | Jul 08, 2024 | T162132 | |
| Certificate of Analysis | Jul 08, 2024 | T162132 | |
| Certificate of Analysis | Mar 29, 2024 | T162132 | |
| Certificate of Analysis | Mar 29, 2024 | T162132 | |
| Certificate of Analysis | Mar 29, 2024 | T162132 | |
| Certificate of Analysis | Mar 29, 2024 | T162132 | |
| Certificate of Analysis | Mar 29, 2024 | T162132 | |
| Certificate of Analysis | Mar 29, 2024 | T162132 | |
| Certificate of Analysis | Mar 29, 2024 | T162132 | |
| Certificate of Analysis | Mar 29, 2024 | T162132 | |
| Certificate of Analysis | Mar 29, 2024 | T162132 | |
| Certificate of Analysis | Mar 13, 2024 | T162132 | |
| Certificate of Analysis | Mar 13, 2024 | T162132 | |
| Certificate of Analysis | Mar 13, 2024 | T162132 | |
| Certificate of Analysis | Dec 07, 2022 | T162132 | |
| Certificate of Analysis | Dec 07, 2022 | T162132 | |
| Certificate of Analysis | Dec 07, 2022 | T162132 | |
| Certificate of Analysis | Dec 07, 2022 | T162132 | |
| Certificate of Analysis | Dec 07, 2022 | T162132 | |
| Certificate of Analysis | Dec 07, 2022 | T162132 | |
| Certificate of Analysis | Dec 07, 2022 | T162132 | |
| Certificate of Analysis | Dec 07, 2022 | T162132 | |
| Certificate of Analysis | Jun 01, 2022 | T162132 | |
| Certificate of Analysis | Jun 01, 2022 | T162132 | |
| Certificate of Analysis | Jun 01, 2022 | T162132 | |
| Certificate of Analysis | Jun 01, 2022 | T162132 |
| Solubility | 3,3′,5-Triiodo-L-thyronine dissolves in 4M NH4OH in MeOH at 5 mg/ml to yield a colorless to light yellow, clear to very slightly hazy solution. |
|---|---|
| Sensitivity | light sensitive |
| Specific Rotation[α] | 23° (C=5,1mol/L HCl:EtOH=1:2) |
| Melt Point(°C) | 234-238°C |
| Molecular Weight | 650.970 g/mol |
| XLogP3 | 1.700 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 5 |
| Exact Mass | 650.79 Da |
| Monoisotopic Mass | 650.79 Da |
| Topological Polar Surface Area | 92.800 Ų |
| Heavy Atom Count | 23 |
| Formal Charge | 0 |
| Complexity | 402.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Mengyuan Liu, Jing Li, Jiali Li, Bingsheng Zhou, Paul K.S. Lam, Chenyan Hu, Lianguo Chen. (2024) Developmental cardiotoxicity of 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in marine medaka (Oryzias melastigma). JOURNAL OF HAZARDOUS MATERIALS, 465 (133176). |
| 2. Wanjiao Chen, Weimin Wang, Chuan-Fan Ding, Fangling Wu, Yifeng Mai. (2023) Precise analysis of thyroxine enantiomers in pharmaceutical formulation by mobility difference based on cyclodextrin. Arabian Journal of Chemistry, 16 (104718). |
| 3. Zhang Mingqi, Wang Le, Zheng Yuqiang, Li Na, He Wei, Wang Zhuoshi. (2023) The use of human-derived feeder layers for the cultivation of transplantable human epidermal cell sheet to repair second degree burn wounds. SKIN RESEARCH AND TECHNOLOGY, 29 (2): (e13290). |
| 4. Liang Siwei, Hu Xinyi, Wang Ruifei, Fang Meimei, Yu Yigang, Xiao Xinglong. (2022) The combination of thymol and cinnamaldehyde reduces the survival and virulence of Listeria monocytogenes on autoclaved chicken breast. JOURNAL OF APPLIED MICROBIOLOGY, 132 (5): (3937-3950). |
| 5. Shuai Liu, Dongxia Li, Dongdong Shi, Guoxian Zhang, Xuyan Luo, Qiang Xu, Liang Zhao, Junping Guo, Guiqin Yan. (2021) Construction of a room-temperature phosphorescent quantum dot probe and quantitative detection of thyroxine and carbamazepine. JOURNAL OF MOLECULAR STRUCTURE, 1229 (129582). |
| 6. Shaojun Liang, Shengxian Liang, Hui Zhou, Nuoya Yin, Francesco Faiola. (2019) Typical halogenated flame retardants affect human neural stem cell gene expression during proliferation and differentiation via glycogen synthase kinase 3 beta and T3 signaling. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 183 (109498). |
| 7. Xiao-Yu Zhu, Sheng-Ya Guo, Bo Xia, Chun-Qi Li, Lei Wang, Yong-Hui Wang. (2019) Development of zebrafish demyelination model for evaluation of remyelination compounds and RORγt inhibitors. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 98 (106585). |
| 8. Mei Yang, Youning Ma, Wenjun Gui, Yiping Ren, Guonian Zhu, Yihua Liu. (2015) Determination of 26 endocrine disrupting chemicals in fish and water using modified QuEChERS combined with solid-phase extraction and UHPLC-MS/MS. Analytical Methods, 7 (19): (8418-8431). |
| 9. Shengxian Liang, Shaojun Liang, Nuoya Yin, Francesco Faiola,. (2019-03-09) Establishment of a human embryonic stem cell-based liver differentiation model for hepatotoxicity evaluations.. Ecotoxicology and environmental safety, ( 353-362 ). |
| 10. Zheyuan Song, Zheng Ma, Xueshan Feng, Rui Huang, Qiong An, Yunrui Pan, Jing Chang, Bin Wan, Huili Wang, Jianzhong Li. (2024) Comparative assessment of thyroid disrupting effects of ethiprole and its metabolites: In silico, in vitro, and in vivo study. Journal of Environmental Sciences, |
| 11. Qiumin Xie, Qin Yi, Jing Zhu, Bin Tan, Han Xiang, Rui Wang, Huiwen Liu, Tangtian Chen, Hao Xu. (2025) Protective role of triiodothyronine in sepsis‑induced cardiomyopathy through phospholamban downregulation. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 55 (3): (1-14). |
| 12. Mengtao Zhang, Jianghong Shi, Bing Li, Hui Ge, Huanyu Tao, Jiawei Zhang, Xiaoyan Li, Zongwei Cai. (2024) Thyroid Hormone Receptor Agonistic and Antagonistic Activity of Newly Synthesized Dihydroxylated Polybrominated Diphenyl Ethers: An In Vitro and In Silico Coactivator Recruitment Study. Toxics, 12 (4): (281). |
| 13. Rong Liu, Lingxuan Huang, Xuan Feng, Di Wang, Rasika Gunarathne, QingJun Kong, Jun Lu, Xueyan Ren. (2024) Unraveling the effective inhibition of α-terpinol and terpene-4-ol against Aspergillus carbonarius: Antifungal mechanism, ochratoxin A biosynthesis inhibition and degradation perspectives. FOOD RESEARCH INTERNATIONAL, 194 (114915). |