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2MeSATP , CAS No.43170-89-4, Agonist of P2Y 11 receptor;Agonist of P2Y 13 receptor;Agonist of P2Y 1 receptor;Antagonist of P2Y 1 receptor;Agonist of P2Y 6 receptor

COA COA
In stock
Item Number
M607128
Grouped product items
SKU Size
Availability
 Price Qty
M607128-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,300.90
M607128-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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Class A GPCR (4138) P2Y1 receptor Agonist (12) P2Y1 receptor Antagonist (18) P2Y11 receptor Agonist (10) P2Y13 receptor Agonist (6) P2Y6 receptor Agonist (13)

Basic Description

Synonyms 2-methylthio-adenosine-5'-triphosphate | 2-methylthioadenosine 5'-triphosphate | 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate) | 2-Mesatp | 2-Methyl-thio-ATP | 2-Methylthio-ATP | 2-Methylthio ATP | CHEMBL336208
Specifications & Purity Moligand™, ≥98%
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type AGONIST, ANTAGONIST
Mechanism of action Agonist of P2Y 11 receptor;Agonist of P2Y 13 receptor;Agonist of P2Y 1 receptor;Antagonist of P2Y 1 receptor;Agonist of P2Y 6 receptor
Product Description

2-MeS-ATP (2-Methylthio-ATP) is an analog of adenosine nucleotides, serving specifically as an agonist for P2Y purinergic receptors (P2Y purinergic receptor). This compound also inhibits the release of toxic mediators by macrophages stimulated by lipopolysaccharides (LPS). It is utilized in research related to endotoxic shock and inflammatory diseases.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Nucleosides, nucleotides, and analogues
Class Purine nucleotides
Subclass Purine ribonucleotides
Intermediate Tree Nodes Not available
Direct Parent Purine ribonucleoside triphosphates
Alternative Parents Purine ribonucleoside monophosphates  Pentose phosphates  Glycosylamines  6-aminopurines  Monosaccharide phosphates  Alkylarylthioethers  Aminopyrimidines and derivatives  Monoalkyl phosphates  N-substituted imidazoles  Imidolactams  Oxolanes  Heteroaromatic compounds  Secondary alcohols  1,2-diols  Sulfenyl compounds  Oxacyclic compounds  Azacyclic compounds  Organic oxides  Primary amines  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Purine ribonucleoside triphosphate - Purine ribonucleoside monophosphate - Pentose phosphate - Pentose-5-phosphate - Glycosyl compound - N-glycosyl compound - 6-aminopurine - Monosaccharide phosphate - Pentose monosaccharide - Imidazopyrimidine - Purine - Aryl thioether - Aminopyrimidine - Alkylarylthioether - Monoalkyl phosphate - Pyrimidine - Alkyl phosphate - Imidolactam - Phosphoric acid ester - Monosaccharide - N-substituted imidazole - Organic phosphoric acid derivative - Azole - Imidazole - Heteroaromatic compound - Oxolane - Secondary alcohol - 1,2-diol - Sulfenyl compound - Thioether - Organoheterocyclic compound - Azacycle - Oxacycle - Hydrocarbon derivative - Alcohol - Organic oxide - Organic oxygen compound - Primary amine - Amine - Organic nitrogen compound - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as purine ribonucleoside triphosphates. These are purine ribobucleotides with a triphosphate group linked to the ribose moiety.
External Descriptors Not available

Associated Targets(Human)

P2RX3 Tclin P2X purinoceptor 3 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
P2RX4 Tchem P2X purinoceptor 4 (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
P2RY1 Tchem P2Y purinoceptor 1 (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
P2RY6 Tchem P2Y purinoceptor 6 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
P2RY11 Tchem P2Y purinoceptor 11 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
P2RY13 Tchem P2Y purinoceptor 13 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
P2RX1 Tchem P2X purinoceptor 1 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2RY12 Tclin Purinergic receptor P2Y12 (2369 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2RY6 Tchem Pyrimidinergic receptor P2Y6 (717 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2RX5 Tchem P2X purinoceptor 5 (52 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2RX4 Tchem P2X purinoceptor 4 (516 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2RX1 Tchem P2X purinoceptor 1 (328 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2RY1 Tchem Purinergic receptor P2Y1 (1327 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2RY11 Tchem Purinergic receptor P2Y11 (134 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ENPP1 Tchem Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (635 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SNCA Tchem Alpha-synuclein (10960 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

P2rx2 P2X purinoceptor 2 (106 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2rx3 P2X purinoceptor 3 (632 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2rx6 P2X purinoceptor 6 (9 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mat2a S-adenosylmethionine synthetase gamma form (83 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Saccharomyces cerevisiae (19171 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cavia porcellus (23802 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Oryctolagus cuniculus (11301 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2RY1 P2Y purinoceptor 1 (470 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name [[(2R,3S,4R,5R)-5-(6-amino-2-methylsulfanylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
INCHI InChI=1S/C11H18N5O13P3S/c1-33-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(27-10)2-26-31(22,23)29-32(24,25)28-30(19,20)21/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H,24,25)(H2,12,14,15)(H2,19,20,21)/t4-,6-,7-,10-/m1/s1
InChIKey XNOBOKJVOTYSJV-KQYNXXCUSA-N
Smiles CSC1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
Isomeric SMILES CSC1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
Alternate CAS 43170-89-4
MeSH Entry Terms 2-MeSATP;2-methyl-thio-ATP;2-methylthio-adenosine 5'-triphosphate;2-methylthio-adenosine-5'-triphosphate;2-methylthio-ATP;2-methylthioadenosine 5'-triphosphate;2MeSATP;MeSATP cpd
Molecular Weight 553.27
Reaxy-Rn 6033938
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6033938&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Molecular Weight 553.280 g/mol
XLogP3 -4.900
Hydrogen Bond Donor Count 7
Hydrogen Bond Acceptor Count 18
Rotatable Bond Count 9
Exact Mass 552.983 Da
Monoisotopic Mass 552.983 Da
Topological Polar Surface Area 304.000 Ų
Heavy Atom Count 33
Formal Charge 0
Complexity 853.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 4
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

  1. 2-Methylthioadenosine triphosphate tetrasodium salt
    2-Methylthioadenosine triphosphate tetrasodium salt
    • ≥98%(HPLC)

    Starting at $299.90

Solution Calculators

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