2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC 50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous sys
Storage Temp
Protected from light,Store at -80°C
Shipped In
Ice chest + Ice pads
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Product Description
2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC 50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB
In Vitro
Primary fibroblast lysates from R191H embryos has lower GEF activity than WT lysates, and 2BAct enhances this activity threefold (EC 50 =7.3 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
2BAct (300 μg 2BAct/g of meal; 21 weeks) normalizes body weight gain in VWM mice . ?\n2BAct prevents the appearance of motor deficits, myelin loss and reactive gliosis in VWM mice . ?\n2BAct stimulates the remaining activity of mutant eIF2B complex in vivo, abrogating the maladaptive stress response . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
This compound belongs to the class of organic compounds known as pyrazinecarboxamides. These are compounds containing a pyrazine ring which bears a carboxamide.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
