Grouped product items

SKU

Size

Availability

Price

Qty

I106793-100mg

100mg

$66.90

I106793-500mg

500mg

$199.90

I106793-1g

$259.90

I106793-2.5g

2.5g

Available within 4-8 weeks(?)

$529.90

I106793-10g

10g

Available within 8-12 weeks(?)

$1,499.90

Basic Description

Synonyms	2IT \| 2(3H)-Thiophenimine, hydrochloride \| NCGC00260958-01 \| 2-IT \| Orafuran \| Trauts reagent \| Traut's reagent \| AKOS015898834 \| DTXSID60524217 \| 2(3H)-Thiophenimine, dihydrochloride \| PD171658 \| 2-Iminothiolane hydrochloride \| ATGUDZODTABURZ-UHFFFAOYSA-
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	RNA-protein crosslinking (sulfhydryl addition) agent. Reacts with primary amines. Maintains charge properties similar to the original amino group.
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	2-Iminothiolane, Hydrochloride is a thiolating agent that is useful in cross-linking proteins. A thiolane derivitization agent. Application： 2-Iminothiolane hydrochloride has been used in the synthesis of thiolated PEG (poly(ethylene glycol). It may be used to synthesize PLA-SH (polyethylene glycol-thiol) and PLA-PEG-SH (polyethylene glycol–polylactic acid-thiol). Thiolating reagent for primary amines. Reacts at pH 7-10 by amidine bond to present free sulfhydryl. Useful in preparation of disulfide and/or thioether linked conjugates.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organosulfur compounds
  - Class Imidothioesters
    - Subclass Imidothiolactones

Kingdom	Organic compounds
Superclass	Organosulfur compounds
Class	Imidothioesters
Subclass	Imidothiolactones
Intermediate Tree Nodes	Not available
Direct Parent	Imidothiolactones
Alternative Parents	Thiolanes Organonitrogen compounds Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aliphatic heteromonocyclic compounds
Substituents	Imidothiolactone - Thiolane - Organoheterocyclic compound - Organic nitrogen compound - Hydrocarbon derivative - Hydrochloride - Organonitrogen compound - Aliphatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as imidothiolactones. These are analogs of imidolactones where the oxygen atom is replaced by a sulfur atom. They have the general structure RC(=N)SR' where the central carbon atom is part of a ring. R,R' = organyl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	thiolan-2-imine;hydrochloride
INCHI	InChI=1S/C4H7NS.ClH/c5-4-2-1-3-6-4;/h5H,1-3H2;1H
InChIKey	ATGUDZODTABURZ-UHFFFAOYSA-N
Smiles	C1CC(=N)SC1.Cl
Isomeric SMILES	C1CC(=N)SC1.Cl
WGK Germany	3
Molecular Weight	137.63
Beilstein	3620079
Reaxy-Rn	3620079
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3620079&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

16 results found

Lot Number	Certificate Type	Date	Item
L2409444	Certificate of Analysis	Nov 25, 2024	I106793
L2409445	Certificate of Analysis	Nov 25, 2024	I106793
L2409446	Certificate of Analysis	Nov 25, 2024	I106793
L2409447	Certificate of Analysis	Nov 25, 2024	I106793
L2321447	Certificate of Analysis	Dec 02, 2023	I106793
L2321448	Certificate of Analysis	Dec 02, 2023	I106793
L2321449	Certificate of Analysis	Dec 02, 2023	I106793
L2321450	Certificate of Analysis	Dec 02, 2023	I106793
L2321451	Certificate of Analysis	Dec 02, 2023	I106793
B2313642	Certificate of Analysis	Dec 09, 2022	I106793
B2313592	Certificate of Analysis	Dec 09, 2022	I106793
B2313552	Certificate of Analysis	Dec 09, 2022	I106793
B2313553	Certificate of Analysis	Dec 09, 2022	I106793
B2313557	Certificate of Analysis	Dec 09, 2022	I106793
I2311030	Certificate of Analysis	Dec 09, 2022	I106793
J2227069	Certificate of Analysis	Nov 27, 2021	I106793

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Chemical and Physical Properties

Solubility	Soluble in Methanol and Water.
Sensitivity	Moisture sensitive；Heat sensitive
Melt Point(°C)	198-201°C
Molecular Weight	137.630 g/mol
XLogP3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Exact Mass	137.007 Da
Monoisotopic Mass	137.007 Da
Topological Polar Surface Area	49.200 Å²
Heavy Atom Count	7
Formal Charge	0
Complexity	69.900
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Alternative Products

Citations of This Product

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6. Yan Xu, Jiwei Liu, Zhangya Liu, Guoguang Chen, Xueming Li, Hao Ren. (2023) Damaging Tumor Vessels with an Ultrasound-Triggered NO Release Nanosystem to Enhance Drug Accumulation and T Cells Infiltration. International Journal of Nanomedicine,
7. Songling Yu, Shengjun Bu, Lulu Xue, Xue Li, Hongyu Zhou, Xiuran Wang, Jiayu Wan. (2023) Ultrasensitive detection of pathogenic bacteria by primer exchange reaction coupled with PGM. MICROCHEMICAL JOURNAL, 187 (108401).
8. Yang Xiao-Yan, Zhang Jin-Guo, Zhou Qiao-Mei, Yu Jie-Ni, Lu Yuan-Fei, Wang Xiao-Jie, Zhou Jia-Ping, Ding Xin-Fa, Du Yong-Zhong, Yu Ri-Sheng. (2022) Extracellular matrix modulating enzyme functionalized biomimetic Au nanoplatform-mediated enhanced tumor penetration and synergistic antitumor therapy for pancreatic cancer. JOURNAL OF NANOBIOTECHNOLOGY, 20 (1): (1-24).
9. Chunhong Mo, Zhao Wang, Jianying Yang, Yiqiang Ouyang, Qian Mo, Shuting Li, Ping He, Limin Chen, Xinchun Li. (2022) Rational assembly of RGD/MoS2/Doxorubicin nanodrug for targeted drug delivery, GSH-stimulus release and chemo-photothermal synergistic antitumor activity. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 233 (112487).
10. Yue Chen, Ning Qiu, Bin Ma, Gan Hu, Deog-Hwan Oh, Xing Fu. (2022) Preparation and characterization of a novel antibacterial hydrogel based on thiolated ovalbumin/gelatin with silver ions. Innovative Food Science & Emerging Technologies, 78 (103007).
11. Jie Li, Peng Liu. (2022) Facile Synthesis of a Redox-Responsive Hyperbranched Polymer Prodrug as a Unimolecular Micelle for the Tumor-Selective Drug Delivery. BIOCONJUGATE CHEMISTRY, 33 (2): (411–417).
12. Yuemeng Yang, Tingting Wu, Li-Ping Xu, Xueji Zhang. (2021) Portable detection of Staphylococcus aureus using personal glucose meter based on hybridization chain reaction strategy. TALANTA, 226 (122132).
13. Ranran Chen, Yuanjian Huang, Lu Wang, Jiahui Zhou, Yuqian Tan, Chaofan Peng, Peng Yang, Wen Peng, Jie Li, Qiou Gu, Yuchen Sheng, Yan Wang, Guoqiang Shao, Qing Zhang, Yueming Sun. (2021) Cetuximab functionalization strategy for combining active targeting and antimigration capacities of a hybrid composite nanoplatform applied to deliver 5-fluorouracil: toward colorectal cancer treatment. Biomaterials Science, 9 (6): (2279-2294).
14. Yuman Dong, Peng Liu. (2020) Reduction-triggered di-block copolymer prodrug for high-performance long-acting tumor-selective killing. COLLOIDS AND SURFACES B-BIOINTERFACES, 196 (111368).
15. Liucheng Zhang, Lu Chen, Yi Xiang, Zhimo Liu, Xiyuan Mao, Lu Zhang, Lianfu Deng, Yuguang Zhang, Liying Cheng, Xiaoming Sun, Wenguo Cui. (2021) Multifunctional integrally-medicalized hydrogel system with internal synergy for efficient tissue regeneration. CHEMICAL ENGINEERING JOURNAL, 406 (126839).
16. Qinjun Chen, Yongqing He, Yu Wang, Chao Li, Yujie Zhang, Qin Guo, Yiwen Zhang, Yongchao Chu, Peixin Liu, Hongyi Chen, Zheng Zhou, Wenxi Zhou, Zhenhao Zhao, Xiaomin Li, Tao Sun, Chen Jiang. (2020) Penetrable Nanoplatform for “Cold” Tumor Immune Microenvironment Reeducation. Advanced Science, 7 (17): (2000411).
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2-Iminothiolane hydrochloride - 98%, high purity , CAS No.4781-83-3