Basic Description

Synonyms	2-Ethyloxazoline \| starbld0019600 \| AKOS015912733 \| E78873 \| Oxazole, 2-ethyl-4,5-dihydro- \| Q26218964 \| 2-Ethyl-4,5-dihydro-1,3-oxazole # \| EINECS 233-912-4 \| B8CD92T4P5 \| 2-Oxazoline, 2-ethyl- \| UNII-B8CD92T4P5 \| Z-1053 \| FT-0699359 \| InChI=1/C5H9NO/c1-
Specifications & Purity	≥98%(GC)
Storage Temp	Argon charged
Shipped In	Normal
Product Description	2-Ethyl-2-oxazoline undergoes cationic ring opening graft polymerization using tosylated cellulose nanowhisker as macroinitiator. 2-Ethyl-2-oxazoline (EtOx) was used in synthesis of block copolymers of EtOx and styrene by cationic ring-opening polymerization and atom transfer radical polymerization.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Azolines
    - Subclass Oxazolines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Azolines
Subclass	Oxazolines
Intermediate Tree Nodes	Not available
Direct Parent	Oxazolines
Alternative Parents	Imidoesters Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Hydrocarbon derivatives
Molecular Framework	Aliphatic heteromonocyclic compounds
Substituents	Oxazoline - Imido ester - Oxacycle - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aliphatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as oxazolines. These are organic compounds containing 1,3-oxazoline, a five-membered ring with a nitrogen and an oxygen atoms at the 1- and 3-position, respectively. Additionally, it contains two double bonds.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	2-ethyl-4,5-dihydro-1,3-oxazole
INCHI	InChI=1S/C5H9NO/c1-2-5-6-3-4-7-5/h2-4H2,1H3
InChIKey	NYEZZYQZRQDLEH-UHFFFAOYSA-N
Smiles	CCC1=NCCO1
Isomeric SMILES	CCC1=NCCO1
WGK Germany	1
UN Number	1993
Packing Group	III
Molecular Weight	99.13
Reaxy-Rn	105464
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=105464&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

18 results found

Lot Number	Certificate Type	Date	Item
L2411423	Certificate of Analysis	Nov 22, 2024	E137961
K2229626	Certificate of Analysis	Sep 12, 2024	E137961
K2229614	Certificate of Analysis	Sep 12, 2024	E137961
I2206779	Certificate of Analysis	Jun 15, 2024	E137961
G2225007	Certificate of Analysis	May 21, 2024	E137961
F2204721	Certificate of Analysis	Mar 21, 2024	E137961
E2423468	Certificate of Analysis	Mar 01, 2024	E137961
E2423469	Certificate of Analysis	Mar 01, 2024	E137961
C2404297	Certificate of Analysis	Feb 23, 2024	E137961
L2125150	Certificate of Analysis	Oct 10, 2023	E137961
L1910058	Certificate of Analysis	Jul 19, 2023	E137961
K2229613	Certificate of Analysis	Oct 26, 2022	E137961
A1909035	Certificate of Analysis	Sep 16, 2022	E137961
I2016422	Certificate of Analysis	Jul 20, 2022	E137961
G2225006	Certificate of Analysis	Jun 24, 2022	E137961
F2204722	Certificate of Analysis	May 20, 2022	E137961
E2203246	Certificate of Analysis	Mar 08, 2022	E137961
E2203245	Certificate of Analysis	Mar 08, 2022	E137961

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Chemical and Physical Properties

Solubility	Fully miscible in water.
Sensitivity	air sensitive
Refractive Index	n20/D 1.437 (lit.)
Flash Point(°F)	84.2 °F
Flash Point(°C)	29 °C
Boil Point(°C)	128.4 °C (lit.)
Melt Point(°C)	−62 °C (lit.)
Molecular Weight	99.130 g/mol
XLogP3	0.300
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	99.0684 Da
Monoisotopic Mass	99.0684 Da
Topological Polar Surface Area	21.600 Å²
Heavy Atom Count	7
Formal Charge	0
Complexity	88.100
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yajie Gao,Chao Zhang,Yanxia Zhou,Jinwen Li,Lei Zhao,Yushu Li,Yan Liu,Xinru Li. (2015-02-14) Endosomal pH-Responsive Polymer-Based Dual-Ligand-Modified Micellar Nanoparticles for Tumor Targeted Delivery and Facilitated Intracellular Release of Paclitaxel.. Pharmaceutical research, 32 ((8)): (2649-2662).
2. Dishi Wang,Yanxia Zhou,Xinru Li,Xiaoyou Qu,Yunqiang Deng,Ziqi Wang,Chuyu He,Yang Zou,Yiguang Jin,Yan Liu. (2017-02-12) Mechanisms of pH-Sensitivity and Cellular Internalization of PEOz-b-PLA Micelles with Varied Hydrophilic/Hydrophobic Ratios and Intracellular Trafficking Routes and Fate of the Copolymer.. ACS applied materials & interfaces, 9 ((8)): (6916-6930).
3. Ziqi Wang,Xinru Li,Dishi Wang,Yang Zou,Xiaoyou Qu,Chuyu He,Yunqiang Deng,Yao Jin,Yuanhang Zhou,Yanxia Zhou,Yan Liu. (2017-08-27) Concurrently suppressing multidrug resistance and metastasis of breast cancer by co-delivery of paclitaxel and honokiol with pH-sensitive polymeric micelles.. Acta biomaterialia, 62 (144-156).
4. Luqiao Wen,Shouzhen Huang,Weiang Du,Caili Zhu,Huan Xu. (2020-01-17) Effects of the molecular weight and molar ratio of poly(2-ethyl-2-oxazoline)-based lipid on the pH sensitivity, stability, and antitumor efficacy of liposomes.. Drug development and industrial pharmacy, 46 ((2)): (283-295).
5. Yuanhang Zhou,Chuhang Zhou,Yang Zou,Yao Jin,Shidi Han,Qi Liu,Xinping Hu,Leqi Wang,Yining Ma,Yan Liu. (2020-08-20) Multi pH-sensitive polymer-drug conjugate mixed micelles for efficient co-delivery of doxorubicin and curcumin to synergistically suppress tumor metastasis.. Biomaterials science, 8 ((18)): (5029-5046).
6. Songlin Xing, Qiqi Wang, Yang He, Li Chen. (2023) Topology Effects of Poly(2-ethyl-2-oxazoline) Brushes with Various Architectures for Antifouling Behavior under Shear Flow. BIOMACROMOLECULES, 24 (7): (3237–3245).
7. Qi Chen, Miaoshen Kou, Yang He, Yiping Zhao, Li Chen. (2022) Constructing hierarchical surface structure of hemodialysis membranes to intervene in oxidative stress through Michael addition reaction between tannic acid and PEtOx brushes. JOURNAL OF MEMBRANE SCIENCE, 657 (120700).
8. Bing Wang, Ping Chen, Ji Zhang, Xiao-Chuan Chen, Yan-Hong Liu, Zheng Huang, Qing-Ying Yu, Ju-Hui Zhang, Wei Zhang, Xi Wei, Xiao-Qi Yu. (2017) Self-assembled core–shell-corona multifunctional non-viral vector with AIE property for efficient hepatocyte-targeting gene delivery. Polymer Chemistry, 8 (48): (7486-7498).
9. Dan-Li Hao,Ran Xie,Ge-Jing De,Hong Yi,Chen Zang,Mi-Yi Yang,Li Liu,Hai Ma,Wei-Yan Cai,Qing-He Zhao,Feng Sui,Yan-Jun Chen. (2020-03-28) pH-Responsive Artesunate Polymer Prodrugs with Enhanced Ablation Effect on Rodent Xenograft Colon Cancer.. International journal of nanomedicine, 15 (1771-1786).
10. Ying-Zi Wu, Yu-Zhuang Gao, Cong-Lei Zhao, Meng-Ying Wu, Yi-Xian Wu. (2024) Amphiphilic Diblock Copolymers of Polyisobutylene-b-Poly(2-Ethyl-2-Oxazoline) via Cationic Polymerization. POLYMER, (127637).
11. Sihan Shen, Ran Xie, Yiqun Wang, Lingyu Jia, Zhangran Zhu, Hai Ma, Lifang Wang, Feng Sui, Yu Zhao, Qinghe Zhao, Yanjun Chen. (2024) Ferroptosis mediated inhibition of breast cancer cells by β–elemene incorporated GSH/pH dual responsive nanomicelles. EUROPEAN POLYMER JOURNAL, (113677).
12. Chengcheng Zhao, Jian Qin, Dingyu Zhang, Xue Li, Ning Yang, Tingyu Gao, Junliang Song, Yule Song, Shouzhen Huang, Huan Xu. (2025) NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate enhances the antitumor effect of quercetin liposomes in triple-negative breast cancer. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY,

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SKU	Size	Availability	Price
E137961-5g	5g	2	$9.90
E137961-25g	25g	3	$29.90
E137961-100g	100g	5	$97.90

2-Ethyl-2-oxazoline - ≥98.0%(GC), high purity , CAS No.10431-98-8