Basic Description

Synonyms	5CFA0332-FB70-485D-A064-6C4C39E7CBA1 \| 2 Deoxy D glucose \| 2-DEOXY-D-GLUCOSE [HSDB] \| EINECS 205-823-0 \| 2-Deoxy-D-mannose \| 2-Deoxy-D-arabino-hexose;D-Arabino-2-deoxyhexose \| 3,3-bis(4-hydroxy-2-methyl-5-propan-2-ylphenyl)-2-benzouran-1-one \| D-2-Deoxygl
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomer
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lipids and lipid-like molecules
  - Class Fatty Acyls
    - Subclass Fatty alcohols

Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Class	Fatty Acyls
Subclass	Fatty alcohols
Intermediate Tree Nodes	Not available
Direct Parent	Fatty alcohols
Alternative Parents	Medium-chain aldehydes Beta-hydroxy aldehydes Alpha-hydrogen aldehydes Secondary alcohols Polyols Primary alcohols Organic oxides Hydrocarbon derivatives
Molecular Framework	Aliphatic acyclic compounds
Substituents	Fatty alcohol - Medium-chain aldehyde - Beta-hydroxy aldehyde - Alpha-hydrogen aldehyde - Secondary alcohol - Polyol - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Primary alcohol - Organooxygen compound - Carbonyl group - Aldehyde - Alcohol - Aliphatic acyclic compound
Description	This compound belongs to the class of organic compounds known as fatty alcohols. These are aliphatic alcohols consisting of a chain of a least six carbon atoms.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

SLC16A1 Tchem Monocarboxylate transporter 1 (146 Activities)

Discover Target: SLC16A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488187422
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488187422
IUPAC Name	(3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal
INCHI	InChI=1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1
InChIKey	VRYALKFFQXWPIH-PBXRRBTRSA-N
Smiles	C(C=O)C(C(C(CO)O)O)O
Isomeric SMILES	C(C=O)[C@H]([C@@H]([C@@H](CO)O)O)O
WGK Germany	3
RTECS	MQ3325000
Molecular Weight	164.16
Beilstein	1723331
Reaxy-Rn	2041872
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2041872&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

25 results found

Lot Number	Certificate Type	Date	Item
A2516113	Certificate of Analysis	Dec 30, 2024	D109194
A2516115	Certificate of Analysis	Dec 30, 2024	D109194
A2516117	Certificate of Analysis	Dec 30, 2024	D109194
A2516118	Certificate of Analysis	Dec 30, 2024	D109194
H2430348	Certificate of Analysis	Aug 19, 2024	D109194
H2430349	Certificate of Analysis	Aug 19, 2024	D109194
H2430350	Certificate of Analysis	Aug 19, 2024	D109194
H2430351	Certificate of Analysis	Aug 19, 2024	D109194
D2408085	Certificate of Analysis	Jun 07, 2023	D109194
G2312782	Certificate of Analysis	Jun 07, 2023	D109194
G2312790	Certificate of Analysis	Jun 07, 2023	D109194
G2312792	Certificate of Analysis	Jun 07, 2023	D109194
G2312774	Certificate of Analysis	Jun 07, 2023	D109194
G2312775	Certificate of Analysis	Jun 07, 2023	D109194
G2312784	Certificate of Analysis	Jun 07, 2023	D109194
G2312783	Certificate of Analysis	Jun 07, 2023	D109194
I2418083	Certificate of Analysis	Jun 07, 2023	D109194
F2312717	Certificate of Analysis	May 15, 2023	D109194
G2205112	Certificate of Analysis	Jun 01, 2022	D109194
G2205098	Certificate of Analysis	Jun 01, 2022	D109194
G2205097	Certificate of Analysis	Jun 01, 2022	D109194
G2205096	Certificate of Analysis	Jun 01, 2022	D109194
E2124231	Certificate of Analysis	Mar 17, 2021	D109194
E2124150	Certificate of Analysis	Mar 17, 2021	D109194
E2124230	Certificate of Analysis	Mar 17, 2021	D109194

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Chemical and Physical Properties

Solubility	Soluble in water.
Specific Rotation[α]	46.5 ° (C=1, H2O)
Melt Point(°C)	146-147°C
Molecular Weight	164.160 g/mol
XLogP3	-2.900
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	164.068 Da
Monoisotopic Mass	164.068 Da
Topological Polar Surface Area	98.000 Å²
Heavy Atom Count	11
Formal Charge	0
Complexity	116.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Wanzhen Li, Yongqi Yang, Jun Wang, Ting Ge, Shuixia Wan, Lin Gui, Yugui Tao, Ping Song, Liangjun Yang, Fei Ge, Weiwei Zhang. (2024) Establishment of bone-targeted nano-platform and the study of its combination with 2-deoxy-d-glucose enhanced photodynamic therapy to inhibit bone metastasis. Journal of the Mechanical Behavior of Biomedical Materials, 150 (106306).
2. Pengfei Sun, Wan Yang, Jiarong He, Liuliang He, Pengfei Chen, Wenjuan Xu, Qingming Shen, Daifeng Li, Quli Fan. (2023) Phenylboronic Acid-Modified Near-Infrared Region Ii Excitation Donor–Acceptor–Donor Molecule for 2-Deoxy-D-Glucose Improved Starvation/Chemo/Photothermal Combination Therapy. Advanced Healthcare Materials, (2302099).
3. Yanzhi Xing, Yulong Xu, Yanna Lin, E Shuang, Han Leng, Jianhua Wang, Xuwei Chen. (2023) Rational synthesis of carbon dots with phosphate ester group for direct mapping of endogenous alkaline phosphatase and polarity monitoring in living cells. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 640 (626).
4. Guangyu Cheng, Lin Li, Qingjie Li, Shulin Lian, Hongbo Chu, Yunlu Ding, Chikun Li, Yan Leng. (2022) β-elemene suppresses tumor metabolism and stem cell-like properties of non-small cell lung cancer cells by regulating PI3K/AKT/mTOR signaling. American Journal of Cancer Research, 12 (4): ( 1535–1555).
5. Hui Chen, Han Zhang, Lixing Cao, Jinling Cui, Xuan Ma, Chong Zhao, Shutao Yin, Hongbo Hu. (2022) Glucose Limitation Sensitizes Cancer Cells to Selenite-Induced Cytotoxicity via SLC7A11-Mediated Redox Collapse. Cancers, 14 (2): (345).
6. Yeneng Dai, Zhiquan Sun, Honghai Zhao, Dashan Qi, Xiangyu Li, Diya Gao, Meixing Li, Quli Fan, Qingming Shen, Wei Huang. (2021) NIR-II fluorescence imaging guided tumor-specific NIR-II photothermal therapy enhanced by starvation mediated thermal sensitization strategy. BIOMATERIALS, 275 (120935).
7. Yuping Wei, Caiying Zhang, Man Zhang, Qionghong Niu, Fengli Hui, Zi Liu, Xia Xu. (2021) Insight of Synergistic Effect between CPP and Cargo on the Facilitation Mechanisms of R7-PTX Translocation: Experiments and Molecular Simulations. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 161 (105790).
8. Yangke Wanyan, Xixi Xu, Kehang Liu, Huidan Zhang, Junai Zhen, Rong Zhang, Jumei Wen, Ping Liu, Yuqing Chen. (2020) 2-Deoxy-d-glucose Promotes Buforin IIb-Induced Cytotoxicity in Prostate Cancer DU145 Cells and Xenograft Tumors. MOLECULES, 25 (23): (5778).
9. Yan Zhiyu, Wu Xiangli, Zhao Mengran, Zhang Jinxia. (2020) Lactic acid accumulation under heat stress related to accelerated glycolysis and mitochondrial dysfunction inhibits the mycelial growth of Pleurotus ostreatus. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 104 (15): (6767-6777).
10. Chen Xiaolong, Hu Cuihua, Zhang Yanan, Hao Wenjing, He Xu, Li Qing, Huang Yuxi, Huang Yibing, Chen Yuxin. (2020) Anticancer Activity and Mechanism of Action of kla-TAT Peptide. International Journal of Peptide Research and Therapeutics, 26 (4): (2285-2296).
11. Yaqun Fang, Xiaoqin He, Pengcheng Zhang, Chuanbin Shen, James Mwangi, Cheng Xu, Guoxiang Mo, Ren Lai, Zhiye Zhang. (2019) In Vitro and In Vivo Antimalarial Activity of LZ1, a Peptide Derived from Snake Cathelicidin. Toxins, 11 (7): (379).
12. Shi Ning, Liu Qiying, Cen Hu, Ju Rongmei, He Xiong, Ma Longlong. (2020) Formation of humins during degradation of carbohydrates and furfural derivatives in various solvents. Biomass Conversion and Biorefinery, 10 (2): (277-287).
13. Liu Ru-Tao, Zhang Min, Yang Chun-Lin, Zhang Peng, Zhang Na, Du Tong, Ge Meng-Ru, Yue Long-Tao, Li Xiao-Li, Li Heng, Duan Rui-Sheng. (2018) Enhanced glycolysis contributes to the pathogenesis of experimental autoimmune neuritis. Journal of Neuroinflammation, 15 (1): (1-13).
14. Mingtong Ye, Sufan Wang, Ting Wan, Rui Jiang, Yun Qiu, Lei Pei, Nengzhi Pang, Yuanling Huang, Yufeng Huang, Zhenfeng Zhang, Lili Yang. (2017) Combined Inhibitions of Glycolysis and AKT/autophagy Can Overcome Resistance to EGFR-targeted Therapy of Lung Cancer. Journal of Cancer, 8 (18): ( 3774–3784).
15. Yuping Wei, Liang Ma, Liang Zhang, Xia Xu. (2017) Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy. International Journal of Nanomedicine, 12 ( 7039–7051).
16. Xianzhi Qu, Jiyao Sheng, Luyan Shen, Jing Su, Yunjie Xu, Qi Xie, Yao Wu, Xuewen Zhang, Liankun Sun. (2017) Autophagy inhibitor chloroquine increases sensitivity to cisplatin in QBC939 cholangiocarcinoma cells by mitochondrial ROS. PLoS One, 12 (3): (e0173712).
17. Quan-Xing Mao, Shuang E, Jun-Mei Xia, Ru-Sheng Song, Yang Shu, Xu-Wei Chen, Jian-Hua Wang. (2016) Hydrophobic Carbon Nanodots with Rapid Cell Penetrability and Tunable Photoluminescence Behavior for in Vitro and in Vivo Imaging. LANGMUIR, 32 (46): (12221–12229).
18. Ming-Zhen Zhang, Yong Yu, Rong-Na Yu, Min Wan, Rong-Ying Zhang, Yuan-Di Zhao. (2013) Tracking the Down-Regulation of Folate Receptor-α in Cancer Cells through Target Specific Delivery of Quantum Dots Coupled with Antisense Oligonucleotide and Targeted Peptide. Small, 9 (24): (4183-4193).
19. Ling Jiang, Liying Zhu, Xian Xu, Ming Lin, Yanping Li, Xiaotong Li, Huaiyan Cui, He Huang. (2013) Bioproduction of hydrogen by simultaneous saccharification and fermentation of cassava starch with 2-deoxyglucose-resistant mutant strains of Clostridium tyrobutyricum. INTERNATIONAL JOURNAL OF HYDROGEN ENERGY, 38 (6349).
20. Yuefang Deng, Shuang Li, Qing Xu, Min Gao, He Huang. (2012) Production of fumaric acid by simultaneous saccharification and fermentation of starchy materials with 2-deoxyglucose-resistant mutant strains of Rhizopus oryzae. BIORESOURCE TECHNOLOGY, 107 (363).
21. Yixuan Xu, Huiping Dang, Changchang Teng, Dalong Yin, Lifeng Yan. (2024) ATP Inhibition for Starvation/Mild Photothermal/Photodynamic Synergy Therapy Using Polypeptide Nanoparticles Conjugating 2-Deoxy-D-Glucose and Dye under NIR Phototheranostic Strategy. Advanced Healthcare Materials, (2401219).
22. Yanzhi Xing, Jiaxin Li, Han Leng, Yanfeng Zhang, Shuang E, Jianhua Wang, Xuwei Chen. (2024) From cell membrane to endoplasmic reticulum: Tunable lipid membrane imaging by regulating the lipophilicity and internalization of carbon dots. CHEMICAL ENGINEERING JOURNAL, 492 (152068).

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SKU	Size	Availability	Price
D109194-1g	1g	5	$58.90
D109194-5g	5g	3	$189.90
D109194-25g	25g	7	$855.90
D109194-100g	100g	1	$3,078.90

2-Deoxy-D-glucose - 98%, high purity , CAS No.154-17-6