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Small Molecules & Compound Libraries
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Metabolic Enzyme/Protease
E1/E2/E3 Enzyme
2-D08 - 98% (HPLC), high purity , CAS No.144707-18-6

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2-D08 - 98% (HPLC), high purity , CAS No.144707-18-6

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 144707-18-6
Molecular Weight: 270.24
PubChem CID: 22507438
PubChem SID: 504769239

In stock

Item Number

D167318

Grouped product items
SKU	Size	Availability	Price
D167318-5mg	5mg	2	$64.90
D167318-10mg	10mg	2	$107.90
D167318-25mg	25mg	2	$227.90
D167318-50mg	50mg	2	$369.90
D167318-100mg	100mg	2	$641.90

View related series

Amino Acid/Protein Metabolism (1836) E1/E2/E3 Enzyme (112) Metabolic Enzyme/Protease (4860) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260) TAM Receptor (37)

Basic Description

Synonyms	PD044048 \| HY-114166 \| SCHEMBL1772778 \| D82631 \| 2-(2,3,4-Trihydroxyphenyl)-4H-chromen-4-one \| BCP18314 \| AMY31051 \| AS-16368 \| 2-(2,3,4-TRIHYDROXYPHENYL)CHROMEN-4-ONE \| 2D08;2 D08 \| AKOS027322100 \| 2',3',4'-trihydroxyflavone \| CCG-267148 \| s8696 \| 2-(2,3
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	2-D08 is a small ubiquitin-like modification protein (sumoylation) inhibitor with cell permeability. 2-D08 also inhibited Axl with IC50 of 0.49 nM.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Flavonoids
    - Subclass Flavones

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Flavonoids
Subclass	Flavones
Intermediate Tree Nodes	Not available
Direct Parent	Flavones
Alternative Parents	4'-hydroxyflavonoids 3'-hydroxyflavonoids Chromones 5-unsubstituted pyrrogallols Pyranones and derivatives 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Benzene and substituted derivatives Heteroaromatic compounds Polyols Oxacyclic compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	3'-hydroxyflavonoid - 4'-hydroxyflavonoid - Flavone - Hydroxyflavonoid - Chromone - Benzopyran - 1-benzopyran - 5-unsubstituted pyrrogallol - Benzenetriol - Pyrogallol derivative - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Pyranone - Monocyclic benzene moiety - Benzenoid - Pyran - Heteroaromatic compound - Organoheterocyclic compound - Oxacycle - Polyol - Organic oxide - Hydrocarbon derivative - Organic oxygen compound - Organooxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as flavones. These are flavonoids with a structure based on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one).
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

APP Tclin Amyloid-beta A4 protein (8510 Activities)

Discover Target: APP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504769239
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504769239
IUPAC Name	2-(2,3,4-trihydroxyphenyl)chromen-4-one
INCHI	InChI=1S/C15H10O5/c16-10-6-5-9(14(18)15(10)19)13-7-11(17)8-3-1-2-4-12(8)20-13/h1-7,16,18-19H
InChIKey	JJAXTFSPCLZPIW-UHFFFAOYSA-N
Smiles	C1=CC=C2C(=C1)C(=O)C=C(O2)C3=C(C(=C(C=C3)O)O)O
Isomeric SMILES	C1=CC=C2C(=C1)C(=O)C=C(O2)C3=C(C(=C(C=C3)O)O)O
WGK Germany	3
Molecular Weight	270.24
Reaxy-Rn	26588215
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26588215&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
K2219472	Certificate of Analysis	Sep 09, 2022	D167318
K2219504	Certificate of Analysis	Sep 09, 2022	D167318
K2219526	Certificate of Analysis	Sep 09, 2022	D167318
C2514404	Certificate of Analysis	Sep 09, 2022	D167318
K2219527	Certificate of Analysis	Sep 09, 2022	D167318
K2219474	Certificate of Analysis	Sep 09, 2022	D167318

Chemical and Physical Properties

Sensitivity	Light sensitive
Molecular Weight	270.240 g/mol
XLogP3	2.500
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Exact Mass	270.053 Da
Monoisotopic Mass	270.053 Da
Topological Polar Surface Area	87.000 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	418.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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