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2-Amio-6-methyl-4-propyl-4H-[1，2，4]triazolo[1，5-a]pyrimidin-5-one - ≥99%, high purity , CAS No.27277-00-5

COA COA
    Grade & Purity:
  • ≥99%
In stock
Item Number
A136526
Grouped product items
SKU Size
Availability
 Price Qty
A136526-250mg
250mg
4
$241.90
A136526-1g
1g
4
$687.90
A136526-5g
5g
1
$2,404.90
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Bulk Order  SDS  DATASHEET  Specification Sheet

PDE4 inhibitor

View related series
Nucleic Acid Metabolism (395)

Basic Description

Synonyms LP01258 | HMS3268I14 | ICI 63,197, >=98% (HPLC) | NCGC00025306-01 | 2-Amio-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one | 2-amino-6-methyl-4-propyl-1,2,4-triazolo[1,5-a]pyrimidin-5(4H)-one | 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]py
Specifications & Purity ≥99%
Biochemical and Physiological Mechanisms Potent phosphodiesterase (PDE) 4 inhibitor (IC50= 35 nM for inhibition of [3H]-rolipram binding to rat brain). Antidepressant following systemic administrationin vivo.
Storage Temp Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Triazolopyrimidines
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Triazolopyrimidines
Alternative Parents Pyrimidones  Vinylogous amides  Triazoles  Heteroaromatic compounds  Lactams  Azacyclic compounds  Organopnictogen compounds  Organooxygen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Triazolopyrimidine - Pyrimidone - Pyrimidine - Azole - Triazole - Heteroaromatic compound - Vinylogous amide - 1,2,4-triazole - Lactam - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as triazolopyrimidines. These are polycyclic aromatic compounds containing triazole ring fused to a pyrimidine ring. Triazole is a five-membered ring consisting of two carbon atoms and three nitrogen atoms. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions.
External Descriptors Not available

Associated Targets(Human)

ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Cruzipain (33337 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
lef Anthrax lethal factor (7585 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488183613
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488183613
IUPAC Name 2-amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one
INCHI InChI=1S/C9H13N5O/c1-3-4-13-7(15)6(2)5-14-9(13)11-8(10)12-14/h5H,3-4H2,1-2H3,(H2,10,12)
InChIKey UQDVRVNMIJAGRK-UHFFFAOYSA-N
Smiles CCCN1C(=O)C(=CN2C1=NC(=N2)N)C
Isomeric SMILES CCCN1C(=O)C(=CN2C1=NC(=N2)N)C
WGK Germany 1
Molecular Weight 207.23
Reaxy-Rn 915087
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=915087&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number Certificate Type Date Item
L1904132 Certificate of Analysis Jul 19, 2023 A136526
C2306595 Certificate of Analysis Mar 16, 2023 A136526
C2306594 Certificate of Analysis Mar 09, 2023 A136526
I2009031 Certificate of Analysis Jul 19, 2022 A136526

Chemical and Physical Properties

Solubility Solvent:ethanol, Max Conc. mg/mL: 20.72, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 20.72, Max Conc. mM: 100
Molecular Weight 207.230 g/mol
XLogP3 0.600
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 2
Exact Mass 207.112 Da
Monoisotopic Mass 207.112 Da
Topological Polar Surface Area 77.000 Ų
Heavy Atom Count 15
Formal Charge 0
Complexity 303.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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