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2-Aminopurine - 98%, high purity , CAS No.452-06-2

1 Citations

COA

Grade & Purity:

≥98%

Cas Number: 452-06-2
Molecular Weight: 135.13
Beilstein Registry Number: 26(3/4)3559
MDL number: MFCD00005566
PubChem CID: 9955
PubChem SID: 488181055

In stock

Item Number

A113172

Grouped product items
SKU	Size	Availability	Price
A113172-100mg	100mg	3	$48.90
A113172-250mg	250mg	3	$110.90
A113172-1g	1g	5	$396.90
A113172-5g	5g	2	$1,786.90
A113172-10g	10g	2	$3,214.90

View related series

Cell Cycle/DNA Damage (2602) DNA Damage (697) DNA Stain (55) Pyrimidines (539) Six-Membered Heterocyclic Compounds (1696)

Basic Description

Synonyms	2-AP \| AKOS006220998 \| 2'-amino-purine \| 2-aminopurine \| NSC24129 \| NSC-24129 \| PD044966 \| 2-amino purine \| HY-W012642 \| NSC 24129 \| AC-13347 \| 2BP \| DTXSID40196416 \| SQ 22,451 \| SQ 22451 \| 1H-PURIN-2-AMINE \| MLS001333096 \| 7H-Purin-2-ylamine \| 9H-Purin-2
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	2-Aminopurine (2AP) is an analog of guanosine and adenosine, which can base pair with cytosine and thymine. It is used as a fluorescent probe in nucleic acid structure and dynamics. 2-Aminopurine (2-AP) inhibits double-stranded RNA-dependent protein kinas
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	2-Aminopurine (2-AP) is used to specifically inhibit double-stranded RNA-dependent protein kinase, protein kinase R (PKR). Product Application： 2-Aminopurine has been used to inhibit eukaryotic initiation factor-2α (eIF2α)-phosphorylation of osteoarthritis (OA) chondrocytes. 2-Aminopurine (2-AP) is used to specifically inhibit double-stranded RNA-dependent protein kinase, protein kinase R (PKR).

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Imidazopyrimidines
    - Subclass Purines and purine derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Imidazopyrimidines
Subclass	Purines and purine derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Purines and purine derivatives
Alternative Parents	Pyrimidines and pyrimidine derivatives Imidazoles Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Purine - Pyrimidine - Heteroaromatic compound - Imidazole - Azole - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as purines and purine derivatives. These are aromatic heterocyclic compounds containing a purine moiety, which is formed a pyrimidine-ring ring fused to an imidazole ring.
External Descriptors	nucleobase analogue - 2-aminopurines
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

XDH Tclin Xanthine dehydrogenase (1038 Activities)

Discover Target: XDH

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

Discover Target: IDH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PI4K2A Tbio Phosphatidylinositol 4-kinase, PI4K (160 Activities)

Discover Target: PI4K2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)

Discover Target: TARDBP

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Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PYGM Glycogen phosphorylase, muscle form (1331 Activities)

Discover Target: PYGM

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488181055
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488181055
IUPAC Name	7H-purin-2-amine
INCHI	InChI=1S/C5H5N5/c6-5-7-1-3-4(10-5)9-2-8-3/h1-2H,(H3,6,7,8,9,10)
InChIKey	MWBWWFOAEOYUST-UHFFFAOYSA-N
Smiles	C1=C2C(=NC(=N1)N)N=CN2
Isomeric SMILES	C1=C2C(=NC(=N1)N)N=CN2
WGK Germany	3
RTECS	UO7475000
Molecular Weight	135.13
Beilstein	26(3/4)3559
Reaxy-Rn	5053
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5053&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
B2327321	Certificate of Analysis	Mar 06, 2023	A113172
L2219102	Certificate of Analysis	Jan 06, 2023	A113172
I1422005	Certificate of Analysis	Jul 14, 2022	A113172
D2220031	Certificate of Analysis	Mar 04, 2022	A113172
D2220026	Certificate of Analysis	Mar 04, 2022	A113172
L2413237	Certificate of Analysis	Mar 04, 2022	A113172
D2220019	Certificate of Analysis	Mar 04, 2022	A113172
D2220025	Certificate of Analysis	Mar 04, 2022	A113172
D2220027	Certificate of Analysis	Mar 04, 2022	A113172
B2327322	Certificate of Analysis	Mar 04, 2022	A113172

Chemical and Physical Properties

Melt Point(°C)	280-282°C
Molecular Weight	135.130 g/mol
XLogP3	-0.200
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Exact Mass	135.054 Da
Monoisotopic Mass	135.054 Da
Topological Polar Surface Area	80.500 Å²
Heavy Atom Count	10
Formal Charge	0
Complexity	127.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Meng Tian, Zhenhua Li, Ruihong Song, Yingxian Li, Chengang Guo, Yujie Sha, Wanling Cui, Shicai Xu, Guodong Hu, Jihua Wang. (2020) Graphene biosensor as affinity biosensors for biorecognition between Guanine riboswitch and ligand. APPLIED SURFACE SCIENCE, 503 (144303).

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