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2-Amino-6-chloropurine - ≥98%, high purity , CAS No.10310-21-1
Basic Description
Synonyms
6-Chloroguanine
Specifications & Purity
≥98%
Shipped In
Normal
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Organoheterocyclic compounds
Class
Imidazopyrimidines
Subclass
Purines and purine derivatives
Intermediate Tree Nodes
Not available
Direct Parent
Purines and purine derivatives
Alternative Parents
Halopyrimidines Aminopyrimidines and derivatives Aryl chlorides Imidazoles Heteroaromatic compounds Azacyclic compounds Primary amines Organopnictogen compounds Organochlorides Hydrocarbon derivatives
Molecular Framework
Aromatic heteropolycyclic compounds
Substituents
Purine - Aminopyrimidine - Halopyrimidine - Aryl chloride - Aryl halide - Pyrimidine - Imidazole - Azole - Heteroaromatic compound - Azacycle - Hydrocarbon derivative - Primary amine - Organonitrogen compound - Organochloride - Organohalogen compound - Organopnictogen compound - Organic nitrogen compound - Amine - Aromatic heteropolycyclic compound
Description
This compound belongs to the class of organic compounds known as purines and purine derivatives. These are aromatic heterocyclic compounds containing a purine moiety, which is formed a pyrimidine-ring ring fused to an imidazole ring.
External Descriptors
organochlorine compound - 2-aminopurines
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
6-chloro-7H-purin-2-amine
INCHI
InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
InChIKey
RYYIULNRIVUMTQ-UHFFFAOYSA-N
Smiles
C1=NC2=C(N1)C(=NC(=N2)N)Cl
Isomeric SMILES
C1=NC2=C(N1)C(=NC(=N2)N)Cl
WGK Germany
3
RTECS
UO7502000
Molecular Weight
169.57
Beilstein
9626
Reaxy-Rn
9626
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9626&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Melt Point(°C)
＞300°C
Molecular Weight
169.570 g/mol
XLogP3
0.400
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
0
Exact Mass
169.016 Da
Monoisotopic Mass
169.016 Da
Topological Polar Surface Area
80.500 Ų
Heavy Atom Count
11
Formal Charge
0
Complexity
154.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
Citations of This Product
1.
Guangrong Sun, Pei Guo, Han Yeong Kaw, Meijiao Zhou, Wei Wang.
(2023)
Uncovering an Emerging Group of Halogenated Nucleobase-Derived Disinfection Byproducts in Drinking Water: Prioritization of the Highly Cytotoxic 2-Chloroadenine. ENVIRONMENTAL SCIENCE & TECHNOLOGY,
57
(23):
(8768–8775).
2.
Meng Tian, Zhenhua Li, Ruihong Song, Yingxian Li, Chengang Guo, Yujie Sha, Wanling Cui, Shicai Xu, Guodong Hu, Jihua Wang.
(2020)
Graphene biosensor as affinity biosensors for biorecognition between Guanine riboswitch and ligand. APPLIED SURFACE SCIENCE,
503
(144303).
3.
Haobo Han, Wenqi Chen, Jiebing Yang, Jiayuan Zhang, Quanshun Li, Yan Yang.
(2018)
2-Amino-6-chloropurine-modified polyamidoamine-mediated p53 gene transfection to achieve anti-tumor efficacy. NEW JOURNAL OF CHEMISTRY,
42
(16):
(13375-13381).
4.
Haobo Han, Jiebing Yang, Yudi Wang, Wenqi Chen, Jiawen Chen, Yan Yang, Quanshun Li.
(2017)
Nucleobase-modified polyamidoamine-mediated miR-23b delivery to inhibit the proliferation and migration of lung cancer. Biomaterials Science,
5
(11):
(2268-2275).
5.
Liu Hongmei, Chang Hong, Lv Jia, Jiang Cong, Li Zhenxi, Wang Fei, Wang Hui, Wang Mingming, Liu Chongyi, Wang Xinyu, Shao Naimin, He Bingwei, Shen Wanwan, Zhang Qiang, Cheng Yiyun.
(2016)
Screening of efficient siRNA carriers in a library of surface-engineered dendrimers. Scientific Reports,
6
(1):
(1-11).
6.
Hui Wang, Haifeng Wei, Quan Huang, Hongmei Liu, Jingjing Hu, Yiyun Cheng, Jianru Xiao.
(2015)
Nucleobase-modified dendrimers as nonviral vectors for efficient and low cytotoxic gene delivery. COLLOIDS AND SURFACES B-BIOINTERFACES,
136
(1148).
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6 Citations
H2407086