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Neuronal Signaling
Amyloid-β
2-(4′-(dimethylamino)phenyl)-6-methyl-benzothiazole , CAS No.10205-62-6

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2-(4′-(dimethylamino)phenyl)-6-methyl-benzothiazole , CAS No.10205-62-6

COA

Cas Number: 10205-62-6
Molecular Weight: 268.38
PubChem CID: 82450

In stock

Item Number

D335342

Grouped product items
SKU	Size	Availability	Price	Qty
D335342-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$89.90

an uncharged derivative of Thioflavin-T

View related series

Amyloid-β (136) Neuronal Signaling (3320)

Basic Description

Synonyms	Dimethyl-[4-(6-methyl-benzothiazol-2-yl)-phenyl]-amine \| doi:10.14272/OEOPVJYUCSQVMJ-UHFFFAOYSA-N.1 \| Z3241262804 \| 10.14272/OEOPVJYUCSQVMJ-UHFFFAOYSA-N.1 \| 2-(4'-(dimethylamino)phenyl)-6-methylbenzothiazole \| 2-(4'-(dimethylamino)phenyl)-6-methyl-benzoth
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	2-(4′-(dimethylamino)phenyl)-6-methyl-benzothiazole is an uncharged derivative of Thioflavin-T, displaying 6-fold higher affinity than Thioflavin-T, and shows high affinity for amyloid deposits [Ki = 143 nM for Ab(1-40)]. It can cross the blood brain barrier, and stains both plaques and neurofibrillary tangles in post mortem Alzheimer's disease brain.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Benzothiazoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Benzothiazoles
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Benzothiazoles
Alternative Parents	Dialkylarylamines Aniline and substituted anilines Thiazoles Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	1,3-benzothiazole - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Aniline or substituted anilines - Monocyclic benzene moiety - Benzenoid - Azole - Thiazole - Heteroaromatic compound - Tertiary amine - Azacycle - Hydrocarbon derivative - Organonitrogen compound - Organopnictogen compound - Organic nitrogen compound - Amine - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as benzothiazoles. These are organic compounds containing a benzene fused to a thiazole ring (a five-membered ring with four carbon atoms, one nitrogen atom and one sulfur atom).
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

Excitation and Emision Ranges	λex 356 nm,λem 437 nm in DMSO

Associated Targets(Human)

APP Tclin Amyloid-beta A4 protein (1 Activities)

Discover Target: APP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APP Tclin Amyloid-beta A4 protein (8510 Activities)

Discover Target: APP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	N,N-dimethyl-4-(6-methyl-1,3-benzothiazol-2-yl)aniline
INCHI	InChI=1S/C16H16N2S/c1-11-4-9-14-15(10-11)19-16(17-14)12-5-7-13(8-6-12)18(2)3/h4-10H,1-3H3
InChIKey	OEOPVJYUCSQVMJ-UHFFFAOYSA-N
Smiles	CC1=CC2=C(C=C1)N=C(S2)C3=CC=C(C=C3)N(C)C
Isomeric SMILES	CC1=CC2=C(C=C1)N=C(S2)C3=CC=C(C=C3)N(C)C
Molecular Weight	268.38
Reaxy-Rn	198588
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=198588&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Molecular Weight	268.400 g/mol
XLogP3	4.700
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Exact Mass	268.103 Da
Monoisotopic Mass	268.103 Da
Topological Polar Surface Area	44.400 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	299.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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