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2,3,5,6-Tetramethylpyrazine - 10mM in DMSO, high purity , CAS No.1124-11-4

    Grade & Purity:
  • 10mM in DMSO
In stock
Item Number
T420649
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T420649-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$69.90
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Compound libraries (12325)

Basic Description

Synonyms DTXCID4027070 | HMS3371J08 | CAS-1124-11-4 | CHUANXIONGQIN | F11202 | Q11319317 | NCGC00247063-01 | NSC 36080 | Z1741976694 | Opera_ID_849 | STL163591 | 2,5,6-Tetramethylpyrazine | Tetrapyrazine | chuanxingzine | EINECS 214-391-2 | EN300-113945 | SMR00005
Specifications & Purity 10mM in DMSO
Storage Temp Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

2,3,5,6-Tetramethylpyrazine is a flavor ingredient in tobacco that has bee used in the treatment of several disorders such as asthma, heart failure, rhinitis and urinary incontinence.
Usually used in research and treatment of multiple disorders.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Diazines
Subclass Pyrazines
Intermediate Tree Nodes Not available
Direct Parent Pyrazines
Alternative Parents Heteroaromatic compounds  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Hydrocarbon derivatives  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Pyrazine - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as pyrazines. These are compounds containing a pyrazine ring, which is a six-member aromatic heterocycle, that consists of two nitrogen atoms (at positions 1 and 4) and four carbon atoms.
External Descriptors Not available

Associated Targets(Human)

Homo sapiens (32628 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ECV-304 (406 Activities)
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HT-29 (80576 Activities)
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K562 (73714 Activities)
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MCF7 (126967 Activities)
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SH-SY5Y (11521 Activities)
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U-87 MG (3946 Activities)
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A549 (127892 Activities)
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Bel-7402 (4577 Activities)
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HCT-116 (91556 Activities)
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HepG2 (196354 Activities)
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HUVEC (11049 Activities)
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HeLa (62764 Activities)
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MDA-MB-231 (73002 Activities)
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ABCB11 Tchem Bile salt export pump (2311 Activities)
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Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
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Rattus norvegicus (775804 Activities)
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PC-12 (7051 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TRXR Thioredoxin reductase (20 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasma (328 Activities)
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Thoracic aorta (838 Activities)
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SARS-CoV-2 (38078 Activities)
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Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 2,3,5,6-tetramethylpyrazine
INCHI InChI=1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3
InChIKey FINHMKGKINIASC-UHFFFAOYSA-N
Smiles CC1=C(N=C(C(=N1)C)C)C
Isomeric SMILES CC1=C(N=C(C(=N1)C)C)C
WGK Germany 3
RTECS UQ3905000
PubChem CID 14296
Molecular Weight 136.19
Beilstein 113100
Reaxy-Rn 113100

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Boil Point(°C) 190°C
Melt Point(°C) 82-86°C
Molecular Weight 136.190 g/mol
XLogP3 1.300
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 0
Exact Mass 136.1 Da
Monoisotopic Mass 136.1 Da
Topological Polar Surface Area 25.800 Ų
Heavy Atom Count 10
Formal Charge 0
Complexity 87.800
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

1. Yue Luo, Siyue Zhu, Jie Peng, Heping Cui, Qingrong Huang, Baojun Xu, Chi-Tang Ho.  (2023)  Feasibility Study of Amadori Rearrangement Products of Glycine, Diglycine, Triglycine, and Glucose as Potential Food Additives for Production, Stability, and Flavor Formation.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,     
2. Hong Yang, Jing Wang, Wenming Cao.  (2023)  Improved liquid-liquid extraction followed by HPLC-UV for accurate and eco-friendly determination of tetramethylpyrazine in vinegar products.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1229  (123869). 
3. Li Chen, Qingshun Nian, Digen Ruan, Jiajia Fan, Yecheng Li, Shunqiang Chen, Lijiang Tan, Xuan Luo, Zhuangzhuang Cui, Yifeng Cheng, Changhao Li, Xiaodi Ren.  (2023)  High-safety and high-efficiency electrolyte design for 4.6 V-class lithium-ion batteries with a non-solvating flame-retardant.  Chemical Science,  14  (5): (1184-1193). 
4. Tong Zhou, Xue Xia, Heping Cui, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2022)  Competitive Formation of 2,3-Butanedione and Pyrazines through Intervention of Added Cysteine during Thermal Processing of Alanine-Xylose Amadori Compounds.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (48): (15202–15212). 
5. Shibin Deng, Yun Zhai, Heping Cui, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2022)  Mechanism of Pyrazine Formation Intervened by Oxidized Methionines during Thermal Degradation of the Methionine–Glucose Amadori Compound.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (45): (14457–14467). 
6. Ren Yanling, Wang Tao, Jiang Yingjie, Chen Pengchao, Tang Jian, Wang Juan, Jin Daochao, Guo Jianjun.  (2022)  Research of Synergistic Substances on Tobacco Beetle [Lasioderma serricorne (Fabricius) (Coleoptera: Anobiidae)] Adults Attractants.  Frontiers in Chemistry,  10   
7. Jian-Li Qiu, Guo-Feng Zhang, Yu-Na Chai, Xiao-Yan Han, Hai-Tao Zheng, Xiang-Feng Li, Fei Duan, Ling-Yan Chen.  (2022)  Ligustrazine Attenuates Liver Fibrosis by Targeting miR-145 Mediated Transforming Growth Factor-β/Smad Signaling in an Animal Model of Biliary Atresia.  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,  381  (3): (257-265). 
8. Tao Tian, Guo-Ying Chen, Hao Zhang, Feng-Qing Yang.  (2021)  Personal Glucose Meter for α-Glucosidase Inhibitor Screening Based on the Hydrolysis of Maltose.  MOLECULES,  26  (15): (4638). 
9. Hanjun Zhang, Furong Tao, Yuezhi Cui, Hongtao Wu.  (2020)  Super-quenching: Multiple migration channels of excitons cause “area quenching”.  MATERIALS CHEMISTRY AND PHYSICS,  243  (122657). 
10. Zhou Wei, Chen Ziyi, Zhang Guohao, Liu Zhigang.  (2019)  Systems pharmacology-based approach for dissecting the mechanisms of pyrazine components in Maotai liquor.  BIOSCIENCE REPORTS,  39  (10):  
11. Hui Wang, Wenxi Zhang, Yatao Cheng, Xinyu Zhang, Nannan Xue, Gaorong Wu, Meng Chen, Kang Fang, Wenbo Guo, Fei Zhou, Herong Cui, Tao Ma, Penglong Wang, Haimin Lei.  (2018)  Design, Synthesis and Biological Evaluation of Ligustrazine-Flavonoid Derivatives as Potential Anti-Tumor Agents.  MOLECULES,  23  (9): (2187). 
12. Chen Long, Liu Tianjun, Wang Qiangsong, Liu Juan.  (2017)  Anti-inflammatory effect of combined tetramethylpyrazine, resveratrol and curcumin in vivo.  BMC Complementary and Alternative Medicine,  17  (1): (1-10). 
13. Qing Wang, Yao Long, Lin Yao, Li Xu, Zhi-Guo Shi, Lanying Xu.  (2016)  Preparation, characterization and application of a reversed phase liquid chromatography/hydrophilic interaction chromatography mixed-mode C18-DTT stationary phase.  TALANTA,  146  (442). 
14. Zhang Xuemei, Wei Junhua, Ma Pengkai, Mu Hongjie, Wang Aiping, Zhang Leiming, Wu Zimei, Sun Kaoxiang.  (2014)  Preparation and evaluation of a novel biodegradable long-acting intravitreal implant containing ligustrazine for the treatment of proliferative vitreoretinopathy.  JOURNAL OF PHARMACY AND PHARMACOLOGY,  67  (2): (160-169). 
15. Qibo Tan, Yongjun Wu, Cen Li, Jing Jin, Lincheng Zhang, Shuoqiu Tong, Zhaofeng Chen, Li Ran, Lu Huang, Zeyan Zuo.  (2024)  Characterization of Key Aroma Compounds of Soy Sauce-like Aroma Produced in Ferment of Soybeans by Bacillus subtilis BJ3-2.  Foods,  13  (17): (2731). 
16. Yuchen Bai, Ningke You, Hongyu Tian, Xuebing Zhao.  (2025)  Characterization of Key Odorants in Hemp Seed Oil Extracted from the Hemp Seeds Roasted Under Various Conditions.  Processes,  13  (2): (530). 
17. Zhe Cai, Qinbo Jiang, Ruihao Zhang, Yifang Ma, Kaini Chen, Shijie Zheng, Peng Li, Cheng Zeng, Hui Zhang.  (2025)  Comparison of extraction and refinement techniques for volatile compound analysis in camellia oil.  FOOD CHEMISTRY,  469  (142501). 
18. Fangfang Shang, Hengdao Quan, Xiaoxun Ma.  (2024)  Enhancing the interface stability of Li/NCM622 batteries by adding 3-trifluoromethyl pyrazole.  Surfaces and Interfaces,  54  (105249). 
19. Yating Rui, Jianfeng Wu, Qunyong Tang, Juan Pu, Wanpeng Wang, Shou-Nian Ding.  (2025)  Molecularly imprinted electrochemical sensor to sensitively detect tetramethylpyrazine in Baijiu.  ANALYST,  150  (5): (887-893). 
20. Mingjing Yin, Jicheng Yuan, Lina Yu, Xinying Ma, Kun Long, Mingyong Chao.  (2024)  Poly(L-lysine) modified glassy carbon electrode for sensitive electrochemical measurement of 2,3,5,6-tetramethylpyrazine.  International Journal of Electrochemical Science,  19  (100500). 

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