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2,2'-Disulfanediyldiethanamine - 95%, high purity , CAS No.51-85-4
Basic Description
Synonyms
cystamine | Decarboxycystine | 2,2'-Dithiobis(ethylamine)
Specifications & Purity
≥95%
Storage Temp
Store at 2-8°C,Protected from light,Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description
Cystamine is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD).
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Organosulfur compounds
Class
Organic disulfides
Subclass
Dialkyldisulfides
Intermediate Tree Nodes
Not available
Direct Parent
Dialkyldisulfides
Alternative Parents
Sulfenyl compounds Organopnictogen compounds Monoalkylamines Hydrocarbon derivatives
Molecular Framework
Aliphatic acyclic compounds
Substituents
Dialkyldisulfide - Sulfenyl compound - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Primary amine - Organonitrogen compound - Primary aliphatic amine - Amine - Aliphatic acyclic compound
Description
This compound belongs to the class of organic compounds known as dialkyldisulfides. These are organic compounds containing a disulfide group R-SS-R' where R and R' are both alkyl groups.
External Descriptors
organic disulfide - primary amino compound
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
2-(2-aminoethyldisulfanyl)ethanamine
INCHI
InChI=1S/C4H12N2S2/c5-1-3-7-8-4-2-6/h1-6H2
InChIKey
APQPRKLAWCIJEK-UHFFFAOYSA-N
Smiles
C(CSSCCN)N
Isomeric SMILES
C(CSSCCN)N
Molecular Weight
152.3
Reaxy-Rn
1736027
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1736027&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Sensitivity
Light sensitive
Molecular Weight
152.300 g/mol
XLogP3
-1.000
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
5
Exact Mass
152.044 Da
Monoisotopic Mass
152.044 Da
Topological Polar Surface Area
103.000 Ų
Heavy Atom Count
8
Formal Charge
0
Complexity
37.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
Citations of This Product
1.
Kunxi Zhang, Yinan Zhu, Tao Wang, Dawei Niu, Zijie Xiahou, Hongzhong Wang, Peiliang Fu, Haiyan Cui, Jingbo Yin.
(2023)
Lubricating Micro-Interface Assisted General Strategy for Preparing dECM-Microparticle–Based Heterogeneous Granular Inks toward 3D Printing. ADVANCED FUNCTIONAL MATERIALS,
(2307886).
2.
Ming Hao, Yanbo Liu, Zhijun Chen, Xiaodong Hu, Tianyi Zhang, Xinyu Zhu, Xingyu He, Bo Yang.
(2022)
Cross-Linked Gamma Polyglutamic Acid/Human Hair Keratin Electrospun Nanofibrous Scaffolds with Excellent Biocompatibility and Biodegradability. Polymers,
14
(24):
(5505).
3.
Yimu Li, Xuling Chen, Jianbo Ji, Lingbing Li, Guangxi Zhai.
(2021)
Redox-responsive nanoparticles based on Chondroitin Sulfate and Docetaxel prodrug for tumor targeted delivery of Docetaxel. CARBOHYDRATE POLYMERS,
255
(117393).
4.
Tehseen Nawaz, Muhammad Ahmad, Jieying Yu, Shiqi Wang, Tianxin Wei.
(2020)
The biomimetic detection of progesterone by novel bifunctional group monomer based molecularly imprinted polymers prepared in UV light. NEW JOURNAL OF CHEMISTRY,
44
(17):
(6992-7000).
5.
Zhoujiang Chen, Zhanlin Zhang, Maohua Chen, Songzhi Xie, Tao Wang, Xiaohong Li.
(2019)
Synergistic antitumor efficacy of hybrid micelles with mitochondrial targeting and stimuli-responsive drug release behavior. Journal of Materials Chemistry B,
7
(9):
(1415-1426).
6.
Guan-Hai Wang, Hua Chen, Yin-Yu Cai, Li Li, Hui-Kang Yang, Qin Li, Zhi-Jiang He, Jian-Tao Lin.
(2018)
Efficient gene vector with size changeable and nucleus targeting in cancer therapy. Materials Science & Engineering C-Materials for Biological Applications,
90
(568).
7.
Chunqi Zhu, Hanbo Zhang, Wei Li, Lihua Luo, Xiaomeng Guo, Zuhua Wang, Fenfen Kong, Qingpo Li, Jie Yang, Yongzhong Du, Jian You.
(2018)
Suppress orthotopic colon cancer and its metastasis through exact targeting and highly selective drug release by a smart nanomicelle. BIOMATERIALS,
161
(144).
8.
Tang Xiuwen, Liu Sufang, Wang Sifeng, Zhang Qin, Cheng Zhiyi.
(2014)
Preparation of reversibly immobilized Jack bean urease on microchannel surface and application for enzyme inhibition assay. Microfluidics and Nanofluidics,
17
(4):
(721-728).
9.
Huilin Chen, Ran Xu, Enyu Xu, Yan Chen, Chunyu Niu, Yin Chen.
(2024)
Construction and performance evaluation of polyguluronic acid polysaccharides-based drug delivery systems. COLLOIDS AND SURFACES B-BIOINTERFACES,
242
(114083).
10.
Xin Wang, Shurong Zhang, Xiaoyue Wang, Liping Zhou, Yang Tang, Yan Xiao, Yu Zhang, Wei Li.
(2024)
β-cyclodextrin-modified carboxymethyl chitosan/hyaluronic acid-based crosslinked composite nanogels as a dual responsive carrier for targeting anti-tumor therapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS,
667
(124917).
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10 Citations
C2513422