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18β-Glycyrrhetinic acid - 97%, high purity , CAS No.471-53-4, Inhibitor of hydroxysteroid 11-beta dehydrogenase 1;Inhibitor of hydroxysteroid 11-beta dehydrogenase 2

22 Citations COA COA
In stock
Item Number
G109797
Grouped product items
SKU Size
Availability
 Price Qty
G109797-1g
1g
4
$21.90
G109797-5g
5g
4
$98.90
G109797-25g
25g
4
$159.90
G109797-100g
100g
3
$574.90
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Gap junction inhibitor

View related series
hydroxysteroid 11-beta dehydrogenase 1 Inhibitor (7) hydroxysteroid 11-beta dehydrogenase 2 Inhibitor (1) Metabolite (5307)

Basic Description

Synonyms 18 beta -Glycyrrhetinic Acid | 3-beta-Hydroxy-11-oxoolean-12-en-30-oic acid | 3beta-Hydroxy-11-oxoolean-12-en-30-oic acid | ENOXOLONE [MI] | DTXCID50669 | Enoxolone (Glycyrrhetin) | (5S,8S,15S,18S,1R,2R,10R,14R,20R)-18-hydroxy-1,2,5,8,15,19,19-heptamethyl
Specifications & Purity Moligand™, ≥97%
Biochemical and Physiological Mechanisms Gap junction inhibitor. Antiviral activity against rotavirus replication in vitro . Shows immunomodulatory, chemopreventive and anti-inflammatory effects in vivo. Orally active.
Shipped In Normal
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of hydroxysteroid 11-beta dehydrogenase 1;Inhibitor of hydroxysteroid 11-beta dehydrogenase 2
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

18 β-Glycyrrhetinic Acid is an aglycone of the triterpenoid Glyccyrrhizic acid, which is found in liquorice. inhibits the PGDH (15-hydroxyprostaglandin dehydrogenase) leading to increased prostaglandin concentration in the digestive system. Also investigated for potential antibiotic activities.
The aglycone of the triterpenoid Glyccyrrhizic acid.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Lipids and lipid-like molecules
Class Prenol lipids
Subclass Triterpenoids
Intermediate Tree Nodes Not available
Direct Parent Triterpenoids
Alternative Parents Cyclohexenones  Secondary alcohols  Cyclic alcohols and derivatives  Monocarboxylic acids and derivatives  Carboxylic acids  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aliphatic homopolycyclic compounds
Substituents Triterpenoid - Cyclohexenone - Cyclic alcohol - Secondary alcohol - Ketone - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Alcohol - Aliphatic homopolycyclic compound
Description This compound belongs to the class of organic compounds known as triterpenoids. These are terpene molecules containing six isoprene units.
External Descriptors Oleanane triterpenoids

Associated Targets(Human)

HSD11B2 Tchem Corticosteroid 11-beta-dehydrogenase isozyme 2 (5 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HSD11B1 Tclin Corticosteroid 11-beta-dehydrogenase isozyme 1 (9 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AKR1B1 Tclin Aldose reductase (1404 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1B1 Tchem Cytochrome P450 1B1 (1148 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTPN2 Tchem T-cell protein-tyrosine phosphatase (1317 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AMY2A Tclin Pancreatic alpha-amylase (74 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A1 Tchem Cytochrome P450 1A1 (1169 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CES2 Tchem Carboxylesterase 2 (583 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSD17B1 Tchem Estradiol 17-beta-dehydrogenase 1 (2224 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTPN6 Tchem Protein-tyrosine phosphatase 1C (687 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTPN7 Tchem Protein-tyrosine phosphatase LC-PTP (886 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTPN11 Tchem Protein-tyrosine phosphatase 2C (2297 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PRKCH Tchem Protein kinase C eta (1863 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CES1 Tchem Acyl coenzyme A:cholesterol acyltransferase (1029 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSD17B2 Tchem Estradiol 17-beta-dehydrogenase 2 (1671 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
1A9 (618 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A-375 (9258 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DLD-1 (17511 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DU-145 (51482 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ECV-304 (406 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCT-8 (3484 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HL-60 (67320 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-29 (80576 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
K562 (73714 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MG-63 (795 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MRC5 (9203 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NHDF (1164 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PANC-1 (6144 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-3 (62116 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Raji (5516 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-28 (48833 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-OV-3 (52876 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SW-1736 (356 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SW480 (6023 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
T98G (1524 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ZR-75-1 (953 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bel-7402 (4577 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Glo1 Glyoxalase I (4 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hsd11b1 11-beta-hydroxysteroid dehydrogenase 1 (202 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cruzipain (33337 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Gusb Beta-glucuronidase (17 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Prkcd Protein kinase C delta (192 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hsd11b2 11-beta-hydroxysteroid dehydrogenase 2 (82 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human gammaherpesvirus 4 (1538 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Brugia malayi (1377 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hepatitis B virus (7925 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human immunodeficiency virus 1 (70413 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hepatitis C virus (23859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
B16 (5829 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDCK (10148 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-12 (7051 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NIH3T3 (5395 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Lewis lung carcinoma cell line (1243 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
4T1 (1737 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
B16-F10 (4610 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PYGM Glycogen phosphorylase, muscle form (1331 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Luciferin 4-monooxygenase (66902 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RHO Rhodopsin (27 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Akr1d1 3-oxo-5-beta-steroid 4-dehydrogenase (2 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nfkbia NF-kappa-B inhibitor alpha (54 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Streptomyces scabiei (197 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV (424 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488181083
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488181083
IUPAC Name (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid
INCHI InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1
InChIKey MPDGHEJMBKOTSU-YKLVYJNSSA-N
Smiles CC1(C2CCC3(C(C2(CCC1O)C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C
Isomeric SMILES C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)C(=O)O
WGK Germany 3
RTECS RK0180000
Molecular Weight 470.68
Beilstein 2229654
Reaxy-Rn 3041142
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3041142&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

17 results found

Lot Number Certificate Type Date Item
K2329314 Certificate of Analysis Dec 06, 2023 G109797
K2329315 Certificate of Analysis Dec 06, 2023 G109797
K2329316 Certificate of Analysis Dec 06, 2023 G109797
I1507075 Certificate of Analysis May 06, 2023 G109797
D2524078 Certificate of Analysis Nov 23, 2022 G109797
A2329682 Certificate of Analysis Nov 23, 2022 G109797
A2329683 Certificate of Analysis Nov 23, 2022 G109797
A2329688 Certificate of Analysis Nov 23, 2022 G109797
A2329690 Certificate of Analysis Nov 23, 2022 G109797
A2329655 Certificate of Analysis Nov 23, 2022 G109797
A2329673 Certificate of Analysis Nov 23, 2022 G109797
A2329654 Certificate of Analysis Nov 23, 2022 G109797
A2329653 Certificate of Analysis Nov 23, 2022 G109797
C2218448 Certificate of Analysis Feb 14, 2022 G109797
C2218430 Certificate of Analysis Feb 14, 2022 G109797
C2218443 Certificate of Analysis Feb 14, 2022 G109797
C2218646 Certificate of Analysis Feb 14, 2022 G109797

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Chemical and Physical Properties

Specific Rotation[α] 162 ° (C=1, MeOH)
Melt Point(°C) 292-295°C
Molecular Weight 470.700 g/mol
XLogP3 6.400
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 1
Exact Mass 470.34 Da
Monoisotopic Mass 470.34 Da
Topological Polar Surface Area 74.600 Ų
Heavy Atom Count 34
Formal Charge 0
Complexity 965.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 9
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Yang Y, Zhu Q, Zhong Y, Cui X, Jiang Z, Wu P, Zheng X, Zhang K, Zhao S.  (2020)  Synthesis, anti-microbial and anti-inflammatory activities of 18β-glycyrrhetinic acid derivatives..  Bioorg Chem,  101  (103985). 
2. Omar Mezghrani,Yue Tang,Xue Ke,Yi Chen,Danrong Hu,Jiasheng Tu,Li Zhao,Nadia Bourkaib.  (2014-12-03)  Hepatocellular carcinoma dually-targeted nanoparticles for reduction triggered intracellular delivery of doxorubicin..  International journal of pharmaceutics,  478  ((2)): (553-568). 
3. Linjun Zou, Yong Hou, Jiawen Zhang, Meiying Chen, Peiying Wu, Changcun Feng, Qinglong Li, Xudong Xu, Zhaocui Sun, Guoxu Ma.  (2023)  Degradable carrier-free spray hydrogel based on self-assembly of natural small molecule for prevention of postoperative adhesion.  Materials Today Bio,  22  (100755). 
4. Qing Yao, Yingying Tang, Sheng Dai, Lihui Huang, Zewei Jiang, Shiming Zheng, Meng Sun, Yitianhe Xu, Ruijie Lu, Tuyue Sun, Huirong Huang, Xinyu Jiang, Xiaomin Yao, Guangyong Lin, Longfa Kou, Ruijie Chen.  (2023)  A Biomimetic Nanoparticle Exerting Protection against Acute Liver Failure by Suppressing CYP2E1 Activity and Scavenging Excessive ROS.  Advanced Healthcare Materials,    (2300571). 
5. Liu Cui, Xi Wang, Zhaoyun Liu, Ziqi Li, Ziwei Bai, Kui Lin, Jian Yang, Yuanlu Cui, Fei Tian.  (2023)  Metal-organic framework decorated with glycyrrhetinic acid conjugated chitosan as a pH-responsive nanocarrier for targeted drug delivery.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  240  (124370). 
6. Wen Zhijie, Fu Hudie, Ye Xuexin, Yang Xuedan, Zhu Shengpeng, Hu Jie, Kang Li, Li Xiaojun, Yang Xinzhou, Hu Yan.  (2023)  Antitumor activities of novel glycyrrhetinic acid-modified lipogel hybrid system in vitro.  JOURNAL OF MATERIALS SCIENCE,  58  (13): (5788-5807). 
7. Jie Hu, Yongsheng Zheng, Zhijie Wen, Hudie Fu, Xuedan Yang, Xuexin Ye, Shengpeng Zhu, Li Kang, Xiaojun Li, Xinzhou Yang, Yan Hu.  (2023)  Construction of redox-sensitive liposomes modified by glycyrrhetinic acid and evaluation of anti-hepatocellular carcinoma activity.  CHEMISTRY AND PHYSICS OF LIPIDS,  252  (105292). 
8. Fanli Shi, Ruilong Li, Wenjing Wang, Xiangyu Yu, Fenxia Zhu, Yiping Huang, Jing Wang, Zhenhai Zhang.  (2023)  Carboxymethyl starch as a solid dispersion carrier to enhance the dissolution and bioavailability of piperine and 18β-glycyrrhetinic acid.  DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,     
9. Yanmin Shen, Ruoyu Li, Peixia Zhao, Wenju Liu, Xiaolong Yang, Zheng Zhang.  (2022)  Equilibrium Solubility of 18β-Glycyrrhetinic Acid in 12 Pure Solvents: Determination, Correlation, and Hansen Solubility Parameter.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,  67  (10): (3243–3251). 
10. Li Li, Anqi Chen, Bingmi Liu, Hao Pan, Yanjie Yu, Yu Liu.  (2022)  Preparation and pharmacokinetics of glycyrrhetinic acid and cell transmembrane peptides modified with liposomes for liver targeted-delivery.  Biomedical Materials,  17  (4): (45006). 
11. Lulu Jin, Zhixin Zhu, Liangjie Hong, Zhefeng Qian, Fang Wang, Zhengwei Mao.  (2023)  ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation.  Bioactive Materials,  19  (38). 
12. Di Zhang, Jianxin Sun, Shiquan Chang, Xing Li, Huimei Shi, Bei Jing, Yachun Zheng, Yi Lin, Guoqiang Qian, Yuwei Pan, Guoping Zhao.  (2021)  Protective effect of 18β‑glycyrrhetinic acid against H2O2‑induced injury in Schwann cells based on network pharmacology and experimental validation.  Experimental and Therapeutic Medicine,  22  (5): (1-9). 
13. Feng Yunhui, Mei Liyan, Wang Maojie, Huang Qingchun, Huang Runyue.  (2021)  Anti-inflammatory and Pro-apoptotic Effects of 18beta-Glycyrrhetinic Acid In Vitro and In Vivo Models of Rheumatoid Arthritis.  Frontiers in Pharmacology,  12  (1688). 
14. Hao Liu, Sijiao Wang, Houyin Shi, Ruirui Zhang, Kunyan Qu, Yue Hu, Xingyu Qu, Chenyun Gan, Jingjing Chen, Xinyu Shi, Mengwu Zhang, Weiling Zeng.  (2021)  Gastric floating tablet improves the bioavailability and reduces the hypokalemia effect of gossypol in vivo.  SAUDI PHARMACEUTICAL JOURNAL,  29  (305). 
15. Ruoning Wang, Xin Wang, Xiaoshun Jia, Honglan Wang, Wen Li, Junsong Li.  (2020)  Impacts of particle size on the cytotoxicity, cellular internalization, pharmacokinetics and biodistribution of betulinic acid nanosuspensions in combined chemotherapy.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  588  (119799). 
16. Li Li, Shasha Han, Chun Yang, Lin Liu, Sengqun Zhao, Xiaofang Wang, Bingmi Liu, Hao Pan, Yu Liu.  (2020)  Glycyrrhetinic acid modified MOFs for the treatment of liver cancer.  NANOTECHNOLOGY,  31  (32): (325602). 
17. Kaili Wang, Chunjing Guo, Shaohua Zou, Yueming Yu, Xinxin Fan, Bingjie Wang, Mengna Liu, Lei Fang, Daquan Chen.  (2018)  Synthesis, characterization and in vitro/in vivo evaluation of novel reduction-sensitive hybrid nano-echinus-like nanomedicine.  Artificial Cells Nanomedicine and Biotechnology,     
18. Saisai Wang, Yong Shen, Runfeng Qiu, Zhiliang Chen, Zhehang Chen, Wenbin Chen.  (2017)  18 β-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration.  INTERNATIONAL JOURNAL OF ONCOLOGY,  51  (2): (615-624). 
19. Ping Zhang, Yang Cao, Huali Chen, Bo Zhou, Wenjing Hu, Liangke Zhang.  (2017)  Preparation and evaluation of glycyrrhetinic acid-modified and honokiol-loaded acoustic nanodroplets for targeted tumor imaging and therapy with low-boiling-point phase-change perfluorocarbon.  Journal of Materials Chemistry B,  5  (29): (5845-5853). 
20. Dagen Zhong, Zonghua Liu, Shasha Xie, Wei Zhang, Yuanming Zhang, Wei Xue.  (2012)  Study on poly(D,L-lactic) microspheres embedded in calcium alginate hydrogel beads as dual drug delivery systems.  JOURNAL OF APPLIED POLYMER SCIENCE,  129  (2): (767-772). 
21. Ma Xuan, Sun Zhenou, Chen Hui, Cao Lixing, Zhao Shuang, Fan Lihong, Zhao Chong, Yin Shutao, Hu Hongbo.  (2024)  18β-glycyrrhetinic acid suppresses Lewis lung cancer growth through protecting immune cells from ferroptosis.  CANCER CHEMOTHERAPY AND PHARMACOLOGY,    (1-11). 
22. Qianhui Zhao, Xinhang Li, Jun Wen, Yinhui He, Nenggan Zheng, Wenchang Li, Albert Cardona, Zhefeng Gong.  (2024)  A two-layer neural circuit controls fast forward locomotion in Drosophila.  CURRENT BIOLOGY,     

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