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12-Ethyl-9-hydroxycamptothecin - 98%, high purity , CAS No.119577-28-5

COA

Grade & Purity:

≥98%

Cas Number: 119577-28-5
Molecular Weight: 392.4
PubChem CID: 135423054

In stock

Item Number

E651740

Grouped product items
SKU	Size	Availability	Price
E651740-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$31.90
E651740-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$50.90
E651740-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$120.90
E651740-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$210.90

Alkaloids Quinoline Alkaloids Alkaloids Pyrrole Alkaloids Phenols Monophenols

View related series

Alkaloids Quinoline Alkaloids Alkaloids Pyrrole Alkaloids Phenols Monophenols (1) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Topoisomerase (150)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC 50 of 679 nM.
Storage Temp	Protected from light,Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC 50 of 679 nM. In Vitro 12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Alkaloids and derivatives
  - Class Camptothecins

Kingdom	Organic compounds
Superclass	Alkaloids and derivatives
Class	Camptothecins
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Camptothecins
Alternative Parents	Terpene lactones Sesquiterpenoids Pyranoindolizines Quinolines and derivatives Pyranopyridines Polyhalopyridines N-acylpyrrolidines Methylpyridines Hydroxypyridines Fatty acid esters Dihydropyridines Dihydropyranones 1-hydroxy-2-unsubstituted benzenoids N-acyl amines Tertiary carboxylic acid amides Tertiary alcohols Secondary ketimines Heteroaromatic compounds Lactones Lactams Carboxylic acid esters Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Monocarboxylic acids and derivatives Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Camptothecin - Terpene lactone - Farsesane sesquiterpenoid - Sesquiterpenoid - Pyranoindolizine - Quinoline - Pyranopyridine - Pyrrolopyridine - Indolizine - Polyhalopyridine - N-acylpyrrolidine - 1-hydroxy-2-unsubstituted benzenoid - Methylpyridine - Hydroxypyridine - Fatty acid ester - Dihydropyridine - Dihydropyranone - Fatty acyl - Benzenoid - Pyridine - Pyran - N-acyl-amine - Heteroaromatic compound - Tertiary carboxylic acid amide - Tertiary alcohol - Secondary ketimine - Pyrrolidine - Lactone - Lactam - Ketimine - Carboxylic acid ester - Carboxamide group - Oxacycle - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Imine - Alcohol - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as camptothecins. These are heterocyclic compounds comprising a planar pentacyclic ring structure, that includes a pyrrolo[3,4-beta]-quinoline moiety (rings A, B and C), conjugated pyridone moiety (ring D) and one chiral center at position 20 within the alpha-hydroxy lactone ring with (S) configuration (the E-ring).
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	(19S)-5,19-diethyl-8,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
INCHI	InChI=1S/C22H20N2O5/c1-3-11-5-6-17(25)13-7-12-9-24-16(19(12)23-18(11)13)8-15-14(20(24)26)10-29-21(27)22(15,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
InChIKey	KWUQFLSWWSXTSZ-QFIPXVFZSA-N
Smiles	CCC1=C2C(=C(C=C1)O)C=C3CN4C(=CC5=C(C4=O)COC(=O)C5(CC)O)C3=N2
PubChem CID	135423054
Molecular Weight	392.4

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 83.33 mg/mL (212.36 mM; Need ultrasonic)
Molecular Weight	392.400 g/mol
XLogP3	1.400
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	392.137 Da
Monoisotopic Mass	392.137 Da
Topological Polar Surface Area	100.000 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	820.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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