Basic Description

Synonyms	MPTP Hydrochloride
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a piperidine derivative and dopaminergic neurotoxin, useful in neurological research. MPTP is metabolized to 1-methyl-4-phenylpyridine (MPP+), which in turn can cause free radical production in vivo a
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Product Description	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride is a dopaminergic neurotoxin experimentally exhibiting severe and irreversible Parkinsonian conditions.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyridines and derivatives
    - Subclass Hydropyridines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyridines and derivatives
Subclass	Hydropyridines
Intermediate Tree Nodes	Not available
Direct Parent	Hydropyridines
Alternative Parents	Benzene and substituted derivatives Trialkylamines Azacyclic compounds Organopnictogen compounds Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Benzenoid - Hydropyridine - Monocyclic benzene moiety - Tertiary aliphatic amine - Tertiary amine - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Organonitrogen compound - Amine - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as hydropyridines. These are compounds containing a hydrogenated pyridine ring (i.e. containing less than the maximum number of double bonds.).
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC18A2 Tclin Synaptic vesicular amine transporter (118 Activities)

Discover Target: SLC18A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHAT Tchem Choline acetylase (63 Activities)

Discover Target: CHAT

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488188334
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488188334
IUPAC Name	1-methyl-4-phenyl-3,6-dihydro-2H-pyridine;hydrochloride
INCHI	InChI=1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
InChIKey	KOWJANGMTAZWDT-UHFFFAOYSA-N
Smiles	CN1CCC(=CC1)C2=CC=CC=C2.Cl
Isomeric SMILES	CN1CCC(=CC1)C2=CC=CC=C2.Cl
WGK Germany	3
RTECS	UT8358950
Molecular Weight	209.715
Beilstein	3707310
Reaxy-Rn	3707312
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3707312&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

38 results found

Lot Number	Certificate Type	Date	Item
E2529421	Certificate of Analysis	May 14, 2025	M132847
E2529487	Certificate of Analysis	May 14, 2025	M132847
E2529500	Certificate of Analysis	May 14, 2025	M132847
E2529509	Certificate of Analysis	May 14, 2025	M132847
H2314465	Certificate of Analysis	May 12, 2025	M132847
H2314468	Certificate of Analysis	May 12, 2025	M132847
E23261097	Certificate of Analysis	Mar 05, 2025	M132847
E2326786	Certificate of Analysis	Mar 05, 2025	M132847
E2326792	Certificate of Analysis	Mar 05, 2025	M132847
E23261083	Certificate of Analysis	Mar 05, 2025	M132847
E2327339	Certificate of Analysis	Mar 05, 2025	M132847
F2520133	Certificate of Analysis	Nov 12, 2024	M132847
K2427519	Certificate of Analysis	Nov 12, 2024	M132847
K2427515	Certificate of Analysis	Nov 12, 2024	M132847
K2427516	Certificate of Analysis	Nov 12, 2024	M132847
K2427517	Certificate of Analysis	Nov 12, 2024	M132847
K2427518	Certificate of Analysis	Nov 12, 2024	M132847
K2225584	Certificate of Analysis	Sep 14, 2024	M132847
K2225585	Certificate of Analysis	Sep 14, 2024	M132847
E2423550	Certificate of Analysis	May 13, 2024	M132847
E2423551	Certificate of Analysis	May 13, 2024	M132847
E2423552	Certificate of Analysis	May 13, 2024	M132847
E2423553	Certificate of Analysis	May 13, 2024	M132847
H2314466	Certificate of Analysis	Aug 03, 2023	M132847
H2314467	Certificate of Analysis	Aug 03, 2023	M132847
H2314469	Certificate of Analysis	Aug 03, 2023	M132847
L2301103	Certificate of Analysis	Aug 03, 2023	M132847
E23261091	Certificate of Analysis	May 05, 2023	M132847
E23261073	Certificate of Analysis	May 05, 2023	M132847
E2326789	Certificate of Analysis	May 05, 2023	M132847
E2326791	Certificate of Analysis	May 05, 2023	M132847
E2326790	Certificate of Analysis	May 05, 2023	M132847
K2225583	Certificate of Analysis	Nov 08, 2022	M132847
K2225575	Certificate of Analysis	Nov 08, 2022	M132847
J2210584	Certificate of Analysis	Jul 20, 2022	M132847
J2210590	Certificate of Analysis	Jul 20, 2022	M132847
J2210583	Certificate of Analysis	Jul 20, 2022	M132847
J2210585	Certificate of Analysis	Jul 20, 2022	M132847

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Chemical and Physical Properties

Solubility	Soluble in DMSO and Water.
Sensitivity	Heat sensitive & Hygroscopic
Melt Point(°C)	249.0 - 254.0 °C
Molecular Weight	209.710 g/mol
XLogP3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	1
Exact Mass	209.097 Da
Monoisotopic Mass	209.097 Da
Topological Polar Surface Area	3.200 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	189.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Chao Guo, Junrong Zhu, Jingwen Wang, Jialin Duan, Shanbo Ma, Ying Yin, Wei Quan, Wei Zhang, Yue Guan, Yi Ding, Aidong Wen, Yingdong Zhang. (2019) Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson's disease. Aging-US, 11 (21): ( 9424–9441).
2. Shuang Li, Jiaxin Liu, Ge Li, Xueyan Zhang, Fei Xu, Zhijiang Fu, Lesheng Teng, Youxin Li, Fengying Sun. (2019) Near-infrared light-responsive, pramipexole-loaded biodegradable PLGA microspheres for therapeutic use in Parkinson's disease. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 141 (1).
3. Ziliang He, Yeye Hu, Ying Zhang, Jing Xie, Zhiqiang Niu, Guigui Yang, Ji Zhang, Zixuan Zhao, Shuai Wei, Haifeng Wu, Weicheng Hu. (2024) Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation. PHYTOMEDICINE, 127 (155494).
4. Xiaomei Wu, Renxiang Yuan, Yichong Xu, Kai Wang, Hong Yuan, Tingting Meng, Fuqiang Hu. (2024) Functionalized lipid nanoparticles modulate the blood-brain barrier and eliminate α-synuclein to repair dopamine neurons. Asian Journal of Pharmaceutical Sciences, (100904).
5. Guo Qinglong, Wang Yi, Yu Liangchen, Guan Liao, Ji Xuefei, Li Xiaohui, Pang Gang, Ren Zhenhua, Ye Lei, Cheng Hongwei. (2024) Nicotine restores olfactory function by activation of prok2R/Akt/FoxO3a axis in Parkinson’s disease. Journal of Translational Medicine, 22 (1): (1-21).
6. Ao Sun, Yu-fei Li, Yang Miao, Hong-xia Wang, Lin-lin Zhang. (2024) Research on the mechanism of Ursolic acid for treating Parkinson's disease by network pharmacology and experimental verification. Heliyon, 10

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SKU	Size	Availability	Price
M132847-25mg	25mg	9	$49.90
M132847-100mg	100mg	6	$139.90
M132847-500mg	500mg	4	$479.90
M132847-1g	1g	2	$759.90
M132847-5g	5g	1	$2,659.90

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride - ≥98%, high purity , CAS No.23007-85-4