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1,4,7,10-Tetraazacyclododecane - 10mM in DMSO, high purity , CAS No.294-90-6

17 Citations COA COA
    Grade & Purity:
  • 10mM in DMSO
  • Cas Number:  294-90-6
  • Molecular Weight:  172.27
  • Beilstein Registry Number:   606114
  • PubChem CID: 64963
In stock
Item Number
T423047
Grouped product items
SKU Size
Availability
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T423047-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
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View related series
Compound libraries (12325)

Basic Description

Synonyms NSC 629374 | S4927 | T1874 | Cyclen, 97% | MLS000069489 | Q63390538 | 1,4,7,10 Tetrazacyclododecane | BP-21532 | NCGC00018128-01 | NCGC00018128-03 | AM20090388 | BCP9000563 | Cyclen | GS-0907 | 5-26-11-00023 (Beilstein Handbook Reference) | CHEBI:37391 |
Specifications & Purity 10mM in DMSO
Storage Temp Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Cyclen is a macrocyclic aza analogue of the crown ether 12-crown-4. Cyclen compounds are capable of selectively binding cations and are used as a ligand with chemicals used in MRI contrast (as well as other imaging) agents.
A macrocyclic aza analogue of the crown ether 12-crown-4

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic nitrogen compounds
Class Organonitrogen compounds
Subclass Amines
Intermediate Tree Nodes Secondary amines
Direct Parent Dialkylamines
Alternative Parents Azacyclic compounds  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular Framework Aliphatic heteromonocyclic compounds
Substituents Azacycle - Organoheterocyclic compound - Secondary aliphatic amine - Organopnictogen compound - Hydrocarbon derivative - Aliphatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as dialkylamines. These are organic compounds containing a dialkylamine group, characterized by two alkyl groups bonded to the amino nitrogen.
External Descriptors azacycloalkane - saturated organic heteromonocyclic parent - crown amine

Associated Targets(Human)

A498 (42825 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHN (49357 Activities)
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CCRF-CEM (65223 Activities)
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COLO 205 (50209 Activities)
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DLD-1 (17511 Activities)
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DMS-273 (14108 Activities)
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HL-60 (67320 Activities)
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HT-29 (80576 Activities)
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K562 (73714 Activities)
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KM12 (47707 Activities)
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M14 (47487 Activities)
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MOLT-4 (49676 Activities)
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OVCAR-3 (48710 Activities)
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OVCAR-5 (45555 Activities)
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OVCAR-8 (47708 Activities)
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RPMI-8226 (44974 Activities)
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RXF 393 (41971 Activities)
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SF-295 (48000 Activities)
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SK-MEL-2 (46422 Activities)
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SK-MEL-28 (48833 Activities)
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SK-MEL-5 (47095 Activities)
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SK-OV-3 (52876 Activities)
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SN12C (47755 Activities)
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SNB-19 (46794 Activities)
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SNB-78 (14240 Activities)
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TK-10 (45540 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U-251 (51189 Activities)
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UACC-257 (46019 Activities)
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UACC-62 (47335 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UO-31 (46270 Activities)
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XF498 (12972 Activities)
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786-0 (47912 Activities)
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A549 (127892 Activities)
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EKVX (44102 Activities)
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NCI-H322M (45589 Activities)
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HCC 2998 (41480 Activities)
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HCT-116 (91556 Activities)
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HOP-18 (11577 Activities)
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NCI-H460 (60772 Activities)
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IGROV-1 (47897 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KM-20L2 (14967 Activities)
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LOX IMVI (44321 Activities)
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HOP-62 (47048 Activities)
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LXFL 529 (14112 Activities)
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M19-MEL (15326 Activities)
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Malme-3M (44254 Activities)
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SNB-75 (44215 Activities)
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NCI-H226 (44470 Activities)
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NCI-H23 (49055 Activities)
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NCI-H522 (44358 Activities)
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Associated Targets(non-human)

Trypanosoma brucei (78846 Activities)
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Plasmodium falciparum (966862 Activities)
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Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 1,4,7,10-tetrazacyclododecane
INCHI InChI=1S/C8H20N4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h9-12H,1-8H2
InChIKey QBPPRVHXOZRESW-UHFFFAOYSA-N
Smiles C1CNCCNCCNCCN1
Isomeric SMILES C1CNCCNCCNCCN1
WGK Germany 3
RTECS XA5253000
UN Number 3259
Packing Group II
Molecular Weight 172.27
Beilstein 606114
Reaxy-Rn 606114
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=606114&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Sensitivity Moisture sensitive
Melt Point(°C) 110-113°C
Molecular Weight 172.270 g/mol
XLogP3 -2.400
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 0
Exact Mass 172.169 Da
Monoisotopic Mass 172.169 Da
Topological Polar Surface Area 48.100 Ų
Heavy Atom Count 12
Formal Charge 0
Complexity 65.099
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Li Zhang, Nanxi Di, Zhi Wang, Song Zhao.  (2023)  Novel positively-charged polyamine nanofiltration membrane prepared by oligomer triggered interfacial polymerization for molecular separation.  JOURNAL OF MEMBRANE SCIENCE,  688  (122129). 
2. Zhiyu Jin, Xiuyang Zou, Guodong Xu, Zhe Sun, Feng Yan.  (2023)  Semi-Interpenetrating Network Anion Exchange Membranes by Thiol–Ene Coupling Reaction for Alkaline Fuel Cells and Water Electrolyzers.  MOLECULES,  28  (14): (5470). 
3. Yu-Ying Li, Feifan Guo, Jin Yang, Jian-Fang Ma.  (2023)  Efficient detection of metronidazole by a glassy carbon electrode modified with a composite of a cyclotriveratrylene-based metal–organic framework and multi-walled carbon nanotubes.  FOOD CHEMISTRY,  425  (136482). 
4. Tingyu Li, Xinzhu Zhang, Yu Zhang, Jixiao Wang, Zhi Wang, Song Zhao.  (2023)  Nanofiltration membrane comprising structural regulator Cyclen for efficient Li+/Mg2+ separation.  DESALINATION,  556  (116575). 
5. Rui Wang, Shu-Hui Yin, Bi-Liu Lan, Heng-Huan Ruan, Zhi-Hui Qiu, Zhong Zhang.  (2023)  Fluorescent water-stable Zn (II) coordination polymers for selective aqueous detection of nitrophenols.  APPLIED ORGANOMETALLIC CHEMISTRY,  37  (4): (e7027). 
6. Ming Wang, Mengxin Li, Zhongyi Ren, Zhaohui Fei, Yingfei Hou, Q. Jason Niu.  (2023)  Novel macrocyclic polyamines regulated nanofiltration membranes: Towards efficient micropollutants removal and molecular separation.  JOURNAL OF MEMBRANE SCIENCE,  668  (121180). 
7. Ying Chen, Zengqiu Yang, Sibu Wang, Qin Ma, Lingyan Li, Xingjie Wu, Qianqian Guo, Ling Tao, Xiangchun Shen.  (2022)  Boosting ROS-Mediated Lysosomal Membrane Permeabilization for Cancer Ferroptosis Therapy.  Advanced Healthcare Materials,  12  (6): (2202150). 
8. Ming Wang, Mengxin Li, Zhaohui Fei, Jiakun Li, Zhongyi Ren, Yingfei Hou.  (2022)  Synergistic regulation of macrocyclic polyamine-based polyamide nanofiltration membranes by the interlayer and surfactant for divalent ions rejection and mono-/di-ions sieving.  DESALINATION,  544  (116131). 
9. Hao Qi, Liu Dong-Xue, Deng Ruiping, Zhong Hai-Xia.  (2022)  Boosting Electrochemical Carbon Dioxide Reduction on Atomically Dispersed Nickel Catalyst.  Frontiers in Chemistry,  9   
10. Hui-Zhen Yang, Ji Zhang, Yu Guo, Lin Pu, Xiao-Qi Yu.  (2021)  A Fluorescent Self-Reporting Vector with GSH Reduction Responsiveness for Nucleic Acid Delivery.  ACS Applied Bio Materials,  4  (7): (5717–5726). 
11. Bo Song, Qi Liu, Hua Ma, Zhixin Tang, Chaolong Liu, Jinhua Zou, Mingqian Tan, Jingli Yuan.  (2020)  Tumor-targetable magnetoluminescent silica nanoparticles for bimodal time-gated luminescence/magnetic resonance imaging of cancer cells in vitro and in vivo.  TALANTA,  220  (121378). 
12. Bing Yan, Qiu-Ping Li.  (2014)  Photofunctional hybrids of lanthanide (Eu3+, Tb3+)/beta-diketonate functionalized MCM-41/SBA-15 mesoporous host prepared with 1,4,7,10-tetraazacyclododecane modified siloxane as covalent linkage.  MICROPOROUS AND MESOPOROUS MATERIALS,  196  (284). 
13. Yafei Su, Huawen Peng, Yongjin Hu, Shaoping Li, Jingyi Rao, Qiang Zhao.  (2024)  Acid and chlorine-resistant cations selective nanofiltration membranes derived from Hoffmann alkylation reaction.  JOURNAL OF MEMBRANE SCIENCE,  697  (122591). 
14. Yan Li, Sisi Tang, Hang Lei, Yuxia Zhong, Yue-Fei Zhang.  (2024)  Efficient recycle of palladium from wastewater by modified fumed nano-silica composites: Synthesis, adsorption, kinetics and mechanisms.  CHEMICAL ENGINEERING RESEARCH & DESIGN,     
15. Su Yafei, Peng Huawen, Liu Xufei, Li Jiapeng, Zhao Qiang.  (2024)  High performance, pH-resistant membranes for efficient lithium recovery from spent batteries.  Nature Communications,  15  (1): (1-9). 
16. Qiang Dong, Enlin Wang, Shaoxiao Liu, Wenze Wu, Baowei Su.  (2024)  Hollow fiber thin-film composite membrane regulated by macrocyclic polyamine molecules for high performance organic solvent nanofiltration.  JOURNAL OF MEMBRANE SCIENCE,  708  (123036). 
17. Ning Gan, Yuqing Lin, Baolong Wu, Yulong Qiu, Haopan Sun, Jingwen Su, Jianguo Yu, Qian Lin, Hideto Matsuyama.  (2025)  Supramolecular-coordinated nanofiltration membranes with quaternary-ammonium Cyclen for efficient lithium extraction from high magnesium/lithium ratio brine.  WATER RESEARCH,  268  (122703). 

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